Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass

Journal of Pediatric Surgery

Volumn 44, Issue 11, 2009, Pages 2067-2070

  Lautz, Timothy B ^a   Sundaram, Shikha S ^a   Whitington, Peter F ^a   Keys, Lisa ^a   Superina, Riccardo A ^a  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

Body mass index; Mesenterico left portal vein bypass; Portal vein obstruction; Portal vein thrombosis; Rex shunt

Indexed keywords

ADOLESCENT; ARTICLE; BLOOD VESSEL GRAFT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHILD; CLINICAL ARTICLE; EXTRAHEPATIC PORTAL VEIN OBSTRUCTION; FEMALE; FOLLOW UP; HUMAN; INFANT; LIVER; MALE; MESENTERIC VEIN; MESENTERICO LEFT PORTAL VEIN BYPASS; POPULATION; PORTAL HYPERTENSION; PORTAL VEIN BLOOD FLOW; PORTAL VEIN OBSTRUCTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SURGICAL TECHNIQUE;

ADOLESCENT; ANASTOMOSIS, SURGICAL; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; FEMALE; GROWTH DISORDERS; HUMANS; HYPERTENSION, PORTAL; INFANT; LIVER CIRCULATION; MALE; MESENTERIC VEINS; PORTAL VEIN; PORTASYSTEMIC SHUNT, SURGICAL; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; VASCULAR SURGICAL PROCEDURES; VENOUS THROMBOSIS;

EID: 70450104018     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2009.05.016     Document Type: Article

References (21)

1. Alonso E.M., Hackworth C., and Whitington P.F. Portal hypertension in children. Clin Liver Dis 1 (1997) 201-222
2. Alvarez F., Bernard O., Brunelle F., et al. Portal obstruction in children. I. Clinical investigation and hemorrhage risk. J Pediatr 103 (1983) 696-702
3. Alvarez F., Bernard O., Brunelle F., et al. Portal obstruction in children. II. Results of surgical portosystemic shunts. J Pediatr 103 (1983) 703-707
4. Superina R.A., and Alonso E.M. Medical and surgical management of portal hypertension in children. Curr Treat Options Gastroenterol 9 (2006) 432-443
5. Shilyansky J., Roberts E.A., and Superina R.A. Distal splenorenal shunts for the treatment of severe thrombocytopenia from portal hypertension in children. J Gastrointest Surg 3 (1999) 167-172
6. Shneider B., Emre S., Groszmann R., et al. Expert pediatric opinion on the report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. Pediatr Transplant 10 (2006) 893-907
7. Superina R., Shneider B., Emre S., et al. Surgical guidelines for the management of extra-hepatic portal vein obstruction. Pediatr Transplant 10 (2006) 908-913
8. Bambini D.A., Superina R., Almond P.S., et al. Experience with the Rex shunt (mesenterico-left portal bypass) in children with extrahepatic portal hypertension. J Pediatr Surg 35 (2000) 13-18
9. de Ville de Goyet J., Alberti D., Falchetti D., et al. Treatment of extrahepatic portal hypertension in children by mesenteric-to-left portal vein bypass: a new physiological procedure. Eur J Surg 165 (1999) 777-781
10. de Ville de Goyet J., Gibbs P., Clapuyt P., et al. Original extrahilar approach for hepatic portal revascularization and relief of extrahepatic portal hypertension related to later portal vein thrombosis after pediatric liver transplantation. Long term results. Transplantation 62 (1996) 71-75
11. Superina R., Bambini D.A., Lokar J., et al. Correction of extrahepatic portal vein thrombosis by the mesenteric to left portal vein bypass. Ann Surg 243 (2006) 515-521
12. Mack C.L., Superina R.A., and Whitington P.F. Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis. J Pediatr 142 (2003) 197-199
13. Mack C.L., Zelko F.A., Lokar J., et al. Surgically restoring portal blood flow to the liver in children with primary extrahepatic portal vein thrombosis improves fluid neurocognitive ability. Pediatrics 117 (2006) e405-e412
14. Sarin S.K., Bansal A., Sasan S., et al. Portal-vein obstruction in children leads to growth retardation. Hepatology 15 (1992) 229-233
15. Menon P., Rao K.L., Bhattacharya A., et al. Extrahepatic portal hypertension: quality of life and somatic growth after surgery. Eur J Pediatr Surg 15 (2005) 82-87
16. Mehrotra R.N., Bhatia V., Dabadghao P., et al. Extrahepatic portal vein obstruction in children: anthropometry, growth hormone, and insulin-like growth factor I. J Pediatr Gastroenterol Nutr 25 (1997) 520-523
17. Stringer M.D. Improved body mass index after mesenterico-portal bypass. Pediatr Surg Int 23 (2007) 539-543
18. Assaad S.N., Cunningham G.R., and Samaan N.A. Abnormal growth hormone dynamics in chronic liver disease do not depend on severe parenchymal disease. Metabolism 39 (1990) 349-356
19. Chiu B., Melin-Aldana H., Pillai S., et al. Factor VII transcription correlates with hepatocyte proliferation and hepatocyte growth factor expression in a rodent extrahepatic portal vein obstruction model. J Am Coll Surg 205 (2007) 277-283
20. Chiu B., Melin-Aldana H., Pillai S., et al. Extrahepatic portal vein obstruction results in hepatocyte proliferation but a decrease in protein-C synthesis. J Pediatr Surg 42 (2007) 796-799
21. Chiu B., Melin-Aldana H., and Superina R.A. Human extrahepatic portal vein obstruction correlates with decreased factor VII and protein C transcription but increased hepatocyte proliferation. J Pediatr Surg 42 (2007) 1768-1771