A randomized trial comparing hypofractionated and conventionally fractionated three-dimensional external-beam radiotherapy for localized prostate adenocarcinoma: AAAAA report on acute toxicity

Strahlentherapie und Onkologie

Volumn 185, Issue 11, 2009, Pages 715-721

  Norkus, Darius ^a   Miller, Albert ^a   Kurtinaitis, Juozas ^a   Haverkamp, Uwe ^b   Popov, Sergey ^c   Prott, Franz Josef ^d   Valuckas, Konstantinas Povilas ^a  

^a VILNIUS UNIVERSITY   (Lithuania)

^b Clemenshospital ^*  (Germany)

^c RIGA EAST UNIVERSITY HOSPITAL   (Latvia)

^d ST JOSEFS HOSPITAL   (Germany)

Author keywords

Acute toxicity; Hypofractionation; Prostate cancer; Radiotherapy

Indexed keywords

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSTATE ADENOCARCINOMA; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; UROGENITAL TRACT DISEASE;

ADENOCARCINOMA; AGED; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; FOLLOW-UP STUDIES; GASTROINTESTINAL TRACT; HUMANS; KAPLAN-MEIER ESTIMATE; LITHUANIA; MALE; MIDDLE AGED; NEOPLASM STAGING; PROSPECTIVE STUDIES; PROSTATE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; RECTUM; SEMINAL VESICLES; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER; UROGENITAL SYSTEM;

EID: 70449884170     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-009-1982-z     Document Type: Article

References (27)

1. M. Bohrer P. Schröder G. Welzel, et al. 2008 Reduced rectal toxcity with ultrasound-based image guided radiotherapy using BAT? (B-mode acquisition and targeting system) for prostata cancer Strahlenther Onkol 184 674 678 10.1007/s00066-008-1837-z 19107349
2. D.J. Brenner A.A. Martinez G.K. Edmundson, et al. 2002 Direct evidence that prostate tumors show high sensitivity to fractionation (low α/β ratio) comparable to late-responding normal tissue Int J Radiat Oncol Biol Phys 2 52 6 13 10.1016/S0360-3016(01)02664-5 (Pubitemid 34041562)
3. J.D. Cox J. Stetz T.F. Pajak 1995 Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1341 1346 1:STN:280:DyaK2M3ivFCrsA%3D%3D 7713792
4. W. Dorr J. Jaal D. Zips 2007 Prostate cancer: biological dose considerations and constraints in tele- and brachytherapy Strahlenther Onkol 183 Suppl2 14 15 10.1007/s00066-007-2006-5 18166999
5. J.F. Fowler P.M. Harari F. Leborgne, et al. 2003 Acute radiation reactions in oral and pharyngeal mucosa: tolerable levels in altered fractionation schedules Radiother Oncol 69 161 168 10.1016/S0167-8140(03)00231-7 14643953 (Pubitemid 37485875)
6. M. Guckenberger M. Flentje 2007 Intensity-modulated radiotherapy (IMRT) of localized prostate cancer. A review and future perspectives Strahlenther Onkol 183 57 62 10.1007/s00066-007-1631-3 17294108 (Pubitemid 46255023)
7. K. Haustermans J.F. Fowler 2000 A comment on proliferation rates in human prostate cancer [Letter] Int J Radiat Oncol Biol Phys 48 297 10.1016/S0360-3016(00)00562-9
8. B.A. Jereczek-Fossa F. Cattani C. Garibaldi, et al. 2007 Transabdominal ultrasonography, computed tomography and electronic portal imaging for 3-dimensional conformal radiotherapy for prostate cancer Strahlenther Onkol 183 610 6 10.1007/s00066-007-1702-5 17960336 (Pubitemid 350124270)
9. Joiner MC, Bentzen SM Baumann M. Time-dose relationships: the linearquadratic approach and the model in clinical practice. In: Steel GG, ed. Basic clinical radiobiology, 3rd edn. London: Arnold, 2002:120-146.
10. S. Junius K. Haustermans B. Bussels, et al. 2007 Hypofractionated intensity modulated irradiation for localized prostate cancer: results from a phase I/II feasibility study Radiat Oncol 2 29 36 10.1186/1748-717X-2-29 17686162
11. K. Kitamura H. Shirato N. Shinohara, et al. 2003 Reduction in acute morbidity using hypofractionated intensity-modulated radiation therapy assisted with a fluoroscopic real-time tumor-tracking system for prostate cancer: preliminary results of a phase I/II study Cancer J 9 268 276 10.1097/00130404-200307000-00009 12967137
12. P.A. Kupelian C.A. Reddy E.A. Klein 2001 Short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: preliminary results on late toxicity and quality of life Int J Radiat Oncol Biol Phys 51 988 993 1:STN:280:DC%2BD3Mnlt1Crsw%3D%3D 11704322
13. P.A. Kupelian T.R. Willoughby C.A. Reddy 2007 Hypofractionated intensity modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience Int J Radiat Oncol Biol Phys 63 1424 1430
14. F. Leborgne J. Fowler 2008 Acute toxicity after hypofractionated conformal radiotherapy for localized prostate cancer: nonrandomized contemporary comparison with standard fractionation Int J Radiat Oncol Biol Phys 72 770 776 18375075
15. H. Lukka C. Hayter P. Warde 2003 A randomized trial comparing two fractionation schedules for patients with localized prostate cancer Int J Radiat Oncol Biol Phys 57 S126
16. B.L. Madsen R.A. His H.T. Pham 2007 Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.4 Gy in five fractions for localized disease: first clinical trial results Int J Radiat Oncol Biol Phys 67 1099 1105 17336216
17. J.M. Martin A. Bayley R. Bristow 2006 A prospective study of hypofractionated radiotherapy for localized prostate cancer Int J Radiat Oncol Biol Phys 66 S35 S36
18. J.M. Martin T.L. Rosewall A. Bayley, et al. 2007 Phase II trial of hypofractionated image-guided intensity-modulated radiotherapy for localized prostate adenocarcinoma Int J Radiat Oncol Biol Phys 69 1084 1089 17606331
19. B. Polat I. Guenther J. Wilbert, et al. 2008 Intra-fractional uncertainties in image-guided intensity-modulated radiotherapy (IMRT) of prostate cancer Strahlenther Onkol 184 668 673 10.1007/s00066-008-1875-6 19107348
20. A. Pollack A.L. Hanlon E.M. Horwitz, et al. 2006 Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial Int J Radiat Oncol Biol Phys 64 518 526 16242256
21. M.A. Ritter J.D. Forman P.A. Kupelian, et al. 2007 A phase I/II trial of dose-per-fraction escalation for prostate cancer Int J Radiat Oncol Biol Phys 69 S174
22. Siegel S, Castellan NJ Jr. Nonparametric statistics for the behavioral sciences, 2nd edn. New York: McGraw-Hill, 1988.
23. G. Soete S. Arcangeli G. De Meerleer 2006 Phase II study of a four-week hypofractionated external beam radiotherapy regimen for prostate cancer: report on acute toxicity Radiother Oncol 80 78 81 10.1016/j.radonc.2006.06.005 16828910 (Pubitemid 44205307)
24. J.J. van Tol-Geerdink P.F. Stalmeier P.C. Pasker-de Jong, et al. 2006 Systematic review of the effect of radiation dose on tumor control and morbidity in the treatment of prostate cancer by 3D-CRT Int J Radiat Oncol Biol Phys 64 534 543 16246497
25. W. Weiss W. Horninger B.C. Forthuber, et al. 2007 Single-institution results of primary external-beam radiation for the treatment of T1-T3 prostate cancer Strahlenther Onkol 183 321 326 10.1007/s00066-007-1672-7 17520186 (Pubitemid 46996068)
26. E.E. Yeoh R.J. Fraser R.E. McGowan 2003 Evidence for efficacy without increased toxicity of hypofractionated radiotherapy for prostate carcinoma: early results of a phase III randomized trial Int J Radiat Oncol Biol Phys 55 943 955 12605972
27. M.J. Zelefsky Z. Fuks M. Hunt, et al. 2001 High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer J Urol 166 876 881 10.1016/S0022-5347(05)65855-7 1:STN:280:DC%2BD3MvksVShug%3D%3D 11490237 (Pubitemid 32750970)