Pomolic acid isolated from the leaves of Licania pittieri inhibits ADP-and epinephrine-induced platelet aggregation and has hypotensive effect on rats

Current Bioactive Compounds

Volumn 5, Issue 3, 2009, Pages 219-225

  Estrada, O ^a   Alvarado Castillo, C ^a   Fernandez, A Z ^a   Lopez, M ^a   Romero Vecchione, E ^b   Vasquez, J ^b   Mendez, J ^b   Conde, D ^b   Cardozo, A ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Cardiovascular screening; Flavonoids; Licania pittieri; Platelets; Pomolic acid; Triterpenoids

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; ARACHIDONIC ACID; ASTILBIN; LICANIA PITTIERI EXTRACT; METHANOL; PLANT EXTRACT; POMOLIC ACID; PROPRANOLOL; QUERCETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; EPISTAXIS; EXPERIMENTAL RAT; FEMALE; HEART RATE; HEMOSTASIS; HUMAN; IC 50; LICANIA PITTIERI; MALE; MEAN ARTERIAL PRESSURE; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTIAL THROMBOPLASTIN TIME; PLANT LEAF; PRIORITY JOURNAL; RAT; THROMBIN TIME; THROMBOCYTE AGGREGATION;

EID: 70449758441     PISSN: 15734072     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340709789054786     Document Type: Article

References (27)

1. Prance, G.T., Sothers, C.A. (2003) Species plantarum: flora of the world. Part 9. Chrysobalanaceae, 1, Chrysobalanus to Parinari. ABRS for the Species Plantarum Steering Committee of the International Organization for Plant Information. Canberra, p. 201.
2. Chabra, S.C.; Mahunnah, R.L.A.; Mshiu, E.N. (1991) Plants used in traditional medicine in Eastern Tanzania. V. Angiosperms (passifloraceae to sapindaceae). J. Ethnopharmacol., 33, 143-157.
3. Gessler, M.C.; Msuya, D.E.; Nkunya, M.H.H.; Nwasumbi, L.B.; Schär, A.; Heimich, M. (1995) Traditional healers in Tanzania: the perception of malaria and its causes. J. Ethnopharmacol., 48, 119-130.
4. Mabberlay, D.J. (1997) The Plant Book, 2nd ed., Cambridge University Press: Cambridge, p. 138.
5. Toledo, C.L.; Kubitzki, K.; Prance, G.H. (1982) Flora de Venezuela, Ediciones Fundación Educación Ambiental. Caracas, 1, 326-350.
6. Albuquerque, U.P.; Monteiro, J.M.; Ramos, M.A.; Amorim, E.L.C. (2007) Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: A quantitative approach J. Ethnopharmacol., 110, 76-91.
7. Mendez, J.; Bilia, A.R.; Morelli, I. (1995) Phytochemical investigations of Licania genus. Flavonoids and triterpenoids from Licania pittieri. Pharm. Acta Helv., 70, 223-226.
8. Vásquez, J.; Méndez, J.; Romero, V.E.; Rosa, F.; Estrada, O. (1995) Principios activos con acción cardiovascular del extracto metanólico de las ramas de Licania pittieri. Acta Cient. Venez., 46, 82.
9. De, Britto, J.; Manickham, V.; Gopalakrishnan, S.; Ushioda, T.; Tanaka, N. (1995) Determination of aglicon chirality in Dihydroflavonol 3-O-α-L Rhamnosides by 1H-NMR Spectroscopy. Chem. Pharm. Bull., 43, 338-339.
10. Dong, L.C.; Xiao-Ping, C. (1992) Pomolic Acid and derivates from the root of Sanguisorba officinalis. Phytochemistry, 31, 1317-1320.
11. Brecher, G.; Cronkite, E.P. (1950) Morphology and enumeration of human blood platelets. J. Appl. Physiol., 3, 365-377.
12. Born, G. (1962) Aggregation of blood platelet by adenoside diphosphate and its reversal. Nature, 194, 927-929.
13. Duarte, J.; Perez-Viscaino, F.; Utrilla, P.; Jiménez, J.; Tamargo, J.; Zarzuelo, A. (1993) Vasodilatadory effects of flavonoids in rat aortic smooth muscle. structure-activity relationships. Gen. Pharmacol., 24, 857-862. (Pubitemid 23231766)
14. Ibarra, M.; Perez-Viscaino, F.; Cogolludo, A.; Duarte, J.; Zaragoza, F.; Lopez, J.; Tamargo, J. (2002) Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atrian. Planta Med., 68, 307-310.
15. Tarazi, R.C.; Dustan, H.P.; Bravo, E.L. (1976) Haemodynamic effects of propranolol in hypertension: a review. Postgrad. Med. J., 52, 92-100.
16. Alkondon, M.; Ray, A.; Sen, P. (1986) Non stereoselective aspects of propranolol pharmacodynamics. Can. J. Physiol. Pharmacol., 64, 1455-1462.
17. Van Zwieten, P.A. (1996) From alpha and beta to I1: an overview of sympathetic receptors involved in blood pressure control targets for drug treatment. J. Cardiovasc. Pharmacol., 27, S5-S10.
18. Woulfe, D.S. (2005) Platelet G protein-coupled receptors in hemostasis and thrombosis. J. Thromb. Haemost., 3, 2193-2200. (Pubitemid 41727197)
19. Offermanns, S.; Toombs, C.F.; Hu, Y.H.; Simon, M.I. (1997) Defective platelet activation in Gα q deficient mice. Nature, 389, 183-186. (Pubitemid 27400600)
20. Jin, J.; Kunapuli, S.P. (1998) Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc. Natl. Acad. Sci. USA, 95, 8070-8074. (Pubitemid 28326067)
21. Mihta, J.; Mihta, P.; Krap, Y.; Lausen, D. (1988) The primary wave of epinephrine induced platelet aggregation represents alpha 2-adrenoceptor status. Thromb. Res., 49, 531-537.
22. Kobilka, B.K.; Matsui, H.; Kobilka, T.S.; Yang-Feng, T.L.; Francke, U.; Caron, M.G.; Lefkowitz, R.J.; Regan, J.W. (1987) Cloning, sequencing, expression of the gene coding for the human platelet alpha2 adrenergic receptor. Science, 238, 650-656.
23. Rhee, S.G. (2001) Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem., 70, 281-312.
24. Burnstock, G. (2004) Introduction: P2 receptors. Curr. Top. Med. Chem., 4, 793-803.
25. Jacobson, K.A.; Moro, S.; Hoffmann, C.; Kim, Y.C.; Kim, H.S.; Ravi, R.G.; Harden, T.K.; Boyer, J.L. (2001) Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. FARMACO, 56, 71-75.
26. Kauffenstein, G.; Bergmeier, W.; Eckly, A.; Ohlmann, P.; León, C.; Cazenave, J.P.; Nieswandt, B.; Gachet, C. (2001) The P2Y12 receptor induces platelet aggregation through weak activation of the alphaIIb beta3 integrin - a phosphoinositide 3-kinase-dependent mechanism. FEBS Lett., 505, 281-290. (Pubitemid 32896681)
27. Bourdon, D.M.; Mahanty, S.K.; Jacobson, K.A.; Boyer, J.L.; Harden, T.K. (2006) (N)-methanocarba-2MeSADP (MRS2365) is a subtypespecific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. J. Thromb. Haemost., 4, 861-868.