A paradigm for commensalism: The role of a specific microbial polysaccharide in health and disease

Nestle Nutrition Workshop Series: Pediatric Program

Volumn 64, Issue , 2009, Pages 1-10

  Kasper, Dennis L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); BACTEROIDES FRAGILIS; HELICOBACTER HEPATICUS; MUS;

BACTERIAL POLYSACCHARIDE; CD4 ANTIGEN; IMMUNOLOGIC FACTOR; TOLL LIKE RECEPTOR 2;

ANIMAL; ARTICLE; BACTEROIDES FRAGILIS; ENTERITIS; GERMFREE ANIMAL; GROWTH, DEVELOPMENT AND AGING; HELICOBACTER; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INTESTINE; METABOLISM; MICROBIOLOGY; MOUSE; PATHOGENICITY; PHYSIOLOGY; SPLEEN; SYMBIOSIS; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD4; BACTEROIDES FRAGILIS; GERM-FREE LIFE; HELICOBACTER; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE SYSTEM; IMMUNOLOGIC FACTORS; INFLAMMATORY BOWEL DISEASES; INTESTINES; MICE; POLYSACCHARIDES, BACTERIAL; SPLEEN; SYMBIOSIS; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 2;

EID: 70449715758     PISSN: 16616677     EISSN: 16623878     Source Type: Book Series    
DOI: 10.1159/000235779     Document Type: Conference Paper

References (20)

1. Hooper LV, Gordon JI: Commensal host-bacterial relationships in the gut. Science 2001;292:1115-1118.
2. Krinos CM, Coyne MJ, Weinacht KG, et al: Extensive surface diversity of a commensal microorganism by multiple DNA inversions. Nature 2001;414:555-558.
3. Baumann H, Tzianabos AO, Brisson JR, et al: Structural elucidation of two capsular polysaccharides from one strain of Bacteroides fragilis using high-resolution NMR spectroscopy. Biochemistry 1992;31:4081-4089.
4. Comstock LE, Kasper DL: Bacterial glycans: key mediators of diverse host immune responses. Cell 2006;126:847-850.
5. Tzianabos AO, Finberg RW, Wang Y, et al: T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria. J Biol Chem 2000;275:6733-6740.
6. Abbas AK, Lichtman AH, Pober JS: Cellular and Molecular Immunology, ed 4. New York, Saunders, 2000.
7. Mazmanian SK, Kasper DL: The love-hate relationship between bacterial polysaccharides and the host immune system. Nat Rev Immunol 2006;6:849-858.
8. Cobb BA, Wang Q, Tzianabos AO, Kasper DL: Polysaccharide processing and presentation by the MHCII pathway. Cell 2004;117:677-687.
9. Duan J, Avci FY, Kasper DL: Microbial carbohydrate depolymerization by antigen-presenting cells: deamination prior to presentation by the MHCII pathway. Proc Natl Acad Sci USA 2008;105:5183-5188.
10. Cobb BA, Kasper DL: Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. Glycobiology 2008;18:707-717.
11. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL: An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005;122:107-118.
12. Mazmanian SK, Round JL, Kasper DL: A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008;453:620-625.
13. Wang Q, McLoughlin RM, Cobb BA, et al: A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med 2006;203:2853-2863.
14. Powrie F, Read S, Mottet C, et al: Control of immune pathology by regulatory T cells. Novartis Found Symp 2003;252:92-114.
15. Ruiz-Perez B, Chung DR, Sharpe AH, et al: Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Proc Natl Acad Sci USA 2005;102:16753-16758.
16. Gerding DN, Johnson S: Clostridium difficile-associated disease, including pseudomembranous colitis; in Fauci AS, Braunwald E, Kasper DL, et al (eds): Harrison's Principles of Internal Medicine, ed 17. New York, McGraw-Hill, 2008, pp 818-821.
17. Strachan DP: Hay fever, hygiene, and household size. BMJ 1989;299:1259-1260.
18. Bjorksten B, Naaber P, Sepp E, Mikelsaar M: The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy 1999;29:342-346.
19. Kirjavainen PV, Apostolou E, Arvola T, et al: Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease. FEMS Immunol Med Microbiol 2001;32:1-7.
20. Kalliomäki M, Kirjavainen P, Eerola E, et al: Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 2001;107:129-134.