Release, biological potency, and biochemical integrity of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) combined with AugmentTM Bone Graft or GEM 21S beta-tricalcium phosphate (β-TCP)

Journal of Controlled Release

Volumn 140, Issue 3, 2009, Pages 250-255

  Young, C S ^a   Ladd, P A ^a   Browning, C F ^a   Thompson, A ^a   Bonomo, J ^a   Shockley, K ^a   Hart, C E ^a  

^a BioMimetic Therapeutics Inc   (United States)

Author keywords

TCP; Bone; Growth factor; Orthopedic; PDGF

Indexed keywords

BETA TRICALCIUM PHOSPHATE; BIOLOGICAL ACTIVITIES; BIOLOGICAL POTENCY; BONE GRAFT; BONE GRAFTING; BONE GROWTH; BONE HEALING; CALVARIAL DEFECTS; CELL-BASED BIOASSAYS; GROWTH FACTOR; HIGH PRESSURE; HOMODIMERS; IN-VITRO; IN-VIVO; MUSCULOSKELETAL INJURIES; PLATELET-DERIVED GROWTH FACTORS; REFERENCE STANDARD; SDS-PAGE; SINGLE BAND; SINGLE PEAK; SURGICAL PROCEDURES;

BIOACTIVITY; BIOASSAY; BLOOD SUBSTITUTES; BONE; CHROMATOGRAPHIC ANALYSIS; DIFFUSERS (OPTICAL); GRAFTING (CHEMICAL); ORGANIC POLYMERS; PEPTIDES; PLATELETS; QUALITY ASSURANCE; SIZE EXCLUSION CHROMATOGRAPHY;

TRANSMISSION CONTROL PROTOCOL;

CALCIUM PHOSPHATE; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BONE GRAFT; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SKULL DEFECT;

ALKALINE PHOSPHATASE; ANIMALS; BIOCOMPATIBLE MATERIALS; CALCIUM PHOSPHATES; CHROMATOGRAPHY, GEL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG IMPLANTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INDICATORS AND REAGENTS; IODINE RADIOISOTOPES; ISOTOPE LABELING; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SKULL;

EID: 70449700092     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.06.030     Document Type: Article

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