Olesoxime (cholest-4-en-3-one, oxime): Analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel

Pain

Volumn 147, Issue 1-3, 2009, Pages 202-209

  Xiao, Wen Hua ^a,b   Zheng, Felix Y ^a   Bennett, Gary J ^a,b   Bordet, Thierry ^c   Pruss, Rebecca M ^c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Trophos SA   (France)

Author keywords

Chemotherapy; Mitochondria; Neuropathic pain; Neuroprotection; TSPO; VDAC

Indexed keywords

ANALGESIC AGENT; MITOCHONDRIAL PROTEIN; NEUROPROTECTIVE AGENT; OLESOXIME; PACLITAXEL; UNCLASSIFIED DRUG;

AFFERENT NERVE GROUP 1; ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG EXPOSURE; DRUG TARGETING; EPIDERMIS; HYPERALGESIA; MALE; NERVE DEGENERATION; NERVE FIBER C; NEUROPATHIC PAIN; NEUROPROTECTION; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; TREATMENT RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; CHOLESTENONES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; EVOKED POTENTIALS; HYPERALGESIA; MALE; NERVE FIBERS; NEURALGIA; NEUROPROTECTIVE AGENTS; PACLITAXEL; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; UBIQUITIN THIOLESTERASE;

EID: 70449678592     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2009.09.006     Document Type: Article

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