메뉴 건너뛰기




Volumn 35, Issue 5, 2009, Pages 1061-1068

Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes

Author keywords

Breast cells; c Ha ras; Estrogen; Organophosphorous pesticides

Indexed keywords

ESTROGEN; MALATHION; PARATHION; PROTEIN C HA RAS; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 70449674876     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000421     Document Type: Article
Times cited : (28)

References (64)
  • 2
    • 0026511163 scopus 로고
    • Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer
    • Falck F Jr, Ricci A Jr, Wolff MS, Godbold J and Deckers P: Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 47: 143-146, 1992.
    • (1992) Arch Environ Health , vol.47 , pp. 143-146
    • Falck Jr., F.1    Ricci Jr., A.2    Wolff, M.S.3    Godbold, J.4    Deckers, P.5
  • 4
    • 23844460171 scopus 로고    scopus 로고
    • Residential proximity to agricultural pesticide use and incidence of breast cancer in California, 1988-1997
    • Reynolds P, Hurley SE, Gunier RB, Yerabati S, Quach T and Hertz A: Residential proximity to agricultural pesticide use and incidence of breast cancer in California, 1988-1997. Environ Health Perspect 113: 993-1000, 2005.
    • (2005) Environ Health Perspect , vol.113 , pp. 993-1000
    • Reynolds, P.1    Hurley, S.E.2    Gunier, R.B.3    Yerabati, S.4    Quach, T.5    Hertz, A.6
  • 6
    • 0036202945 scopus 로고    scopus 로고
    • Identification of mammary carcinogens in rodent bioassays
    • Bennett LM and Davis BJ: Identification of mammary carcinogens in rodent bioassays. Environ Mol Mutagen 39: 150-157, 2002.
    • (2002) Environ Mol Mutagen , vol.39 , pp. 150-157
    • Bennett, L.M.1    Davis, B.J.2
  • 7
    • 0038353642 scopus 로고    scopus 로고
    • Environmental pollutants and breast cancer
    • Brody JG and Rudel RA: Environmental pollutants and breast cancer. Environ Health Perspect 111: 1007-1019, 2003.
    • (2003) Environ Health Perspect , vol.111 , pp. 1007-1019
    • Brody, J.G.1    Rudel, R.A.2
  • 8
    • 0023836871 scopus 로고
    • Estrogens as a cause of human cancer: The Richard and Hinda Rosenthal foundation award lecture
    • Henderson BE, Ross R and Bernstein L: Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res 48: 246-253, 1988. (Pubitemid 18045752)
    • (1988) Cancer Research , vol.48 , Issue.2 , pp. 246-253
    • Henderson, B.E.1    Ross, R.2    Bernstein, L.3
  • 10
    • 0027182529 scopus 로고
    • Endogenous hormones and breast cancer risk
    • Bernstein L and Ross RK: Endogenous hormones and breast cancer risk. Epidemiol Rev 15: 48-65, 1993. (Pubitemid 23269070)
    • (1993) Epidemiologic Reviews , vol.15 , Issue.1 , pp. 48-65
    • Bernstein, L.1    Ross, R.K.2
  • 11
    • 0027304028 scopus 로고
    • Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk
    • Pike MC, Spicer DV, Dahmoush L and Press MF: Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 15: 17-35, 1993. (Pubitemid 23269068)
    • (1993) Epidemiologic Reviews , vol.15 , Issue.1 , pp. 17-35
    • Pike, M.C.1    Spicer, D.V.2    Dahmoush, L.3    Press, M.F.4
  • 12
    • 0024387728 scopus 로고
    • Mutations in p53 gene occur in diverse human tumor types
    • Nigro JM, Baker SJ, Preisinger AC, et al: Mutations in p53 gene occur in diverse human tumor types. Nature 342: 705-708, 1989.
    • (1989) Nature , vol.342 , pp. 705-708
    • Nigro, J.M.1    Baker, S.J.2    Preisinger, A.C.3
  • 13
    • 0025876591 scopus 로고
    • The p53 tumor suppressor gene
    • Levine AJ, Momand J and Finlay CA: The p53 tumor suppressor gene. Nature 351: 453-456, 1991.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 14
    • 0026636551 scopus 로고
    • P53 mutations, another breast cancer prognostic factor
    • Callahan R: p53 mutations, another breast cancer prognostic factor. J Natl Cancer Inst 84: 826-827, 1992.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 826-827
    • Callahan, R.1
  • 15
    • 0036210784 scopus 로고    scopus 로고
    • Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens
    • DOI 10.1002/em.10052
    • Russo J, Tahin Q, Lareef MH, Hu YF and Russo IH: Neoplastic transformation of human breast epithelial cells by estrogens and chemical carcinogens. Environ Mol Mutagen 39: 254-263, 2002. (Pubitemid 34260500)
    • (2002) Environmental and Molecular Mutagenesis , vol.39 , Issue.2-3 , pp. 254-263
    • Russo, J.1    Tahin, Q.2    Lareef, M.H.3    Hu, Y.-F.4    Russo, I.H.5
  • 17
    • 0028870394 scopus 로고
    • Genomic instability and the role of p53 mutations in cancer cells
    • Smith ML and Fornace AJ Jr: Genomic instability and the role of p53 mutations in cancer cells. Curr Opin Oncol 7: 69-75, 1995.
    • (1995) Curr Opin Oncol , vol.7 , pp. 69-75
    • Smith, M.L.1    Fornace Jr., A.J.2
  • 18
    • 0029022018 scopus 로고
    • Mutations of ras genes in human tumours
    • Review
    • Kiaris H and Spandidos DA: Mutations of ras genes in human tumours (Review). Int J Oncol 7: 413-421, 1995.
    • (1995) Int J Oncol , vol.7 , pp. 413-421
    • Kiaris, H.1    Spandidos, D.A.2
  • 19
    • 0030855153 scopus 로고    scopus 로고
    • Expression of ras proto-oncogenes: Regulation an implications in the development of human tumors
    • Zachos G and Spandidos DA: Expression of ras proto-oncogenes: regulation an implications in the development of human tumors. Crit Rev Oncol Hematol 26: 65-75, 1997.
    • (1997) Crit Rev Oncol Hematol , vol.26 , pp. 65-75
    • Zachos, G.1    Spandidos, D.A.2
  • 20
    • 0037350610 scopus 로고    scopus 로고
    • Allelic imbalance at 11p15.5-15.4 Correlated with C-HA-RAS mutation during radiation-induced neoplastic transformation of human breast epithelial cells
    • DOI 10.1002/ijc.10895
    • Roy D, Calaf G and Hei TK: Allelic imbalance at 11p15.5-15.4 correlated with c-Ha-ras mutation during radiation-induced neoplastic transformation of human breast epithelial cells. Int J Cancer 103: 730-737, 2003. (Pubitemid 36110228)
    • (2003) International Journal of Cancer , vol.103 , Issue.6 , pp. 730-737
    • Roy, D.1    Calaf, G.2    Hei, T.K.3
  • 21
    • 0021975809 scopus 로고
    • Oncogenes in human cancers and in chemically induced animal tumors
    • Barbacid M: Oncogenes in human cancers and in chemically induced animal tumors. Prog Med Virol 32: 86-100, 1985.
    • (1985) Prog Med Virol , vol.32 , pp. 86-100
    • Barbacid, M.1
  • 23
    • 0024376173 scopus 로고
    • Ras Oncogenes in human cancer: A review
    • Bos JL: Ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689, 1989. (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 24
    • 0021742115 scopus 로고
    • Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene
    • Spandidos DA and Agnantis NJ: Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene. Anticancer Res 4: 269-272, 1984.
    • (1984) Anticancer Res , vol.4 , pp. 269-272
    • Spandidos, D.A.1    Agnantis, N.J.2
  • 26
    • 0029987371 scopus 로고    scopus 로고
    • The frequency and mechanism of loss of heterozygosity on chromosome 11q in breast cancer
    • DOI 10.1002/(SICI)1096-9896(199609)180:1<38::AID-PATH638>3.0.CO;2-C
    • Tomlinson IP, Nicolai H, Solomon E and Bodmer WF: The frequency and mechanism of loss of heterozygosity on chromosome 11q in breast cancer. J Pathol 180: 38-43, 1996. (Pubitemid 26348889)
    • (1996) Journal of Pathology , vol.180 , Issue.1 , pp. 38-43
    • Tomlinson, I.P.M.1    Nicolai, H.2    Solomon, E.3    Boomer, W.F.4
  • 27
    • 0031014544 scopus 로고    scopus 로고
    • Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22
    • Iida A, Isobe R, Yoshimoto M, Kasumi F, Nakamura Y and Emi M: Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22. Br J Cancer 75: 264-267, 1997. (Pubitemid 27019572)
    • (1997) British Journal of Cancer , vol.75 , Issue.2 , pp. 264-267
    • Iida, A.1    Isobe, R.2    Yoshimoto, M.3    Kasumi, F.4    Nakamura, Y.5    Emi, M.6
  • 29
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G and Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260: 816-819, 1993. (Pubitemid 23167612)
    • (1993) Science , vol.260 , Issue.5109 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 30
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • DOI 10.1038/363558a0
    • Ionov Y, Peinado MA, Malkhosyan S, Shibata D and Perucho M: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561, 1993. (Pubitemid 23186645)
    • (1993) Nature , vol.363 , Issue.6429 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 31
    • 0034031046 scopus 로고    scopus 로고
    • Microsatellite instability markers in breast cancer: A review and study showing MSI was not detected at 'BAT 25' and 'BAT 26' microsatellite markers in early-onset breast cancer
    • Siah SP, Quinn DM, Bennett GD, Casey G, Flower RL, Suthers G and Rudzki Z: Microsatellite instability markers in breast cancer: a review and study showing MSI was not detected at 'BAT 25' and 'BAT 26' microsatellite markers in early-onset breast cancer. Breast Cancer Res Treat 60: 135-142, 2000.
    • (2000) Breast Cancer Res Treat , vol.60 , pp. 135-142
    • Siah, S.P.1    Quinn, D.M.2    Bennett, G.D.3    Casey, G.4    Flower, R.L.5    Suthers, G.6    Rudzki, Z.7
  • 32
    • 0035110850 scopus 로고    scopus 로고
    • Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer
    • Rennstam K, Baldetorp B, Kytola S, Tanner M and Isola J: Chromosomal rearrangements and oncogene amplification precede aneuploidization in the genetic evolution of breast cancer. Cancer Res 61: 1214-1219, 2001. (Pubitemid 32174445)
    • (2001) Cancer Research , vol.61 , Issue.3 , pp. 1214-1219
    • Rennstam, K.1    Baldetorp, B.2    Kytola, S.3    Tanner, M.4    Isola, J.5
  • 34
    • 0027194058 scopus 로고
    • Transformation of human breast epithelial cells by chemical carcinogens
    • Calaf G and Russo J: Transformation of human breast epithelial cells by chemical carcinogens. Carcinogenesis 14: 483-492, 1993. (Pubitemid 23152785)
    • (1993) Carcinogenesis , vol.14 , Issue.3 , pp. 483-492
    • Calaf, G.1    Russo, J.2
  • 35
    • 0034009528 scopus 로고    scopus 로고
    • Establishment of a radiation- And estrogen-induced breast cancer model
    • Calaf GM and Hei TK: Establishment of a radiation- and estrogen-induced breast cancer model. Carcinogenesis 21: 769-776, 2000. (Pubitemid 30214035)
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 769-776
    • Calaf, G.M.1    Hei, T.K.2
  • 36
    • 0035139638 scopus 로고    scopus 로고
    • Oncoprotein expression in human breast epithelial cells transformed by high-LET radiation
    • DOI 10.1080/095530001453096
    • Calaf G and Hei TK: Oncoprotein expression in human breast epithelial cells transformed by high-LET radiation. Int J Radiat Biol 77: 31-40, 2001. (Pubitemid 32096694)
    • (2001) International Journal of Radiation Biology , vol.77 , Issue.1 , pp. 31-40
    • Calaf, G.1    Hei, T.K.2
  • 37
    • 34547481699 scopus 로고    scopus 로고
    • Susceptibility of human breast epithelial cells in vitro to hormones and drugs
    • Calaf GM: Susceptibility of human breast epithelial cells in vitro to hormones and drugs. Int J Oncol 28: 285-295, 2006.
    • (2006) Int J Oncol , vol.28 , pp. 285-295
    • Calaf, G.M.1
  • 39
    • 0015834582 scopus 로고
    • Isolation of high-molecular-weight DNA from mammalian cells
    • Gross-Bellard M, Oudet P and Chambon P: Isolation of high-molecular- weight DNA from mammalian cells. Eur J Biochem 36: 32-38, 1973.
    • (1973) Eur J Biochem , vol.36 , pp. 32-38
    • Gross-Bellard, M.1    Oudet, P.2    Chambon, P.3
  • 40
    • 0034784811 scopus 로고    scopus 로고
    • Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells
    • Roy D, Calaf G and Hei TK: Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells. Carcinogenesis 22: 1685-1692, 2001. (Pubitemid 32952148)
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1685-1692
    • Roy, D.1    Calaf, G.2    Hei, T.K.3
  • 41
    • 70449630906 scopus 로고
    • International Agency for Research on Cancer IARC Scientific Publications, Lyon
    • International Agency for Research on Cancer: Monographs on the evaluation of carcinogenic risks to humans. Vol.30, IARC Scientific Publications, Lyon, pp102-129, 1983.
    • (1983) Monographs on the Evaluation of Carcinogenic Risks to Humans , vol.30 , pp. 102-129
  • 42
    • 0003415155 scopus 로고
    • International Agency for Research on Cancer IARC Scientific Publications, Lyon
    • International Agency for Research on Cancer: Monographs on the evaluation of carcinogenic risks to humans. Vols. 1-42, IARC Scientific Publications, Lyon, 1987.
    • (1987) Monographs on the Evaluation of Carcinogenic Risks to Humans , vol.1-42
  • 43
    • 0023239438 scopus 로고
    • Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays
    • Tennant RW, Margolin BH, Shelby MD, et al: Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236: 933-941, 1987.
    • (1987) Science , vol.236 , pp. 933-941
    • Tennant, R.W.1    Margolin, B.H.2    Shelby, M.D.3
  • 44
    • 0031908996 scopus 로고    scopus 로고
    • Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests
    • DOI 10.1093/mutage/13.2.157
    • Hour TC, Chen L and Lin JK: Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests. Mutagenesis 13: 157-166, 1998. (Pubitemid 28138300)
    • (1998) Mutagenesis , vol.13 , Issue.2 , pp. 157-166
    • Hour, T.-C.1    Chen, L.2    Lin, J.-K.3
  • 45
    • 0035863776 scopus 로고    scopus 로고
    • Cytogenetic studies on the effect of feeding mice with stored wheat grains treated with malathion
    • Amer SM, Fahmy MA, Aly FA and Farghaly AA: Cytogenetic studies on the effect of feeding mice with stored wheat grains treated with malathion. Mutat Res 513: 1-10, 2002.
    • (2002) Mutat Res , vol.513 , pp. 1-10
    • Amer, S.M.1    Fahmy, M.A.2    Aly, F.A.3    Farghaly, A.A.4
  • 46
    • 0035964433 scopus 로고    scopus 로고
    • Cytogenetic monitoring of Croatian population occupationally exposed to a complex mixture of pesticides
    • DOI 10.1016/S0300-483X(01)00419-X, PII S0300483X0100419X
    • Garaj-Vrhovac V and Zeljezic D: Cytogenetic monitoring of croatian population occupationally exposed to a complex mixture of pesticides. Toxicology 165: 153-162, 2001. (Pubitemid 32778307)
    • (2001) Toxicology , vol.165 , Issue.2-3 , pp. 153-162
    • Garaj-Vrhovac, V.1    Zeljezic, D.2
  • 47
    • 0036020579 scopus 로고    scopus 로고
    • Assessment of genome damage in a population of Croatian workers employed in pesticide production by chromosomal aberration analyis, micronucleus assay and Comet assay
    • DOI 10.1002/jat.855
    • Garaj-Vrhovac V and Zeljezic D: Assessment of genome damage in a population of Croatian workers employed in pesticide production by chromosomal aberration analysis, micronucleus assay and Comet assay. J Appl Toxicol 22: 249-255, 2002. (Pubitemid 34830749)
    • (2002) Journal of Applied Toxicology , vol.22 , Issue.4 , pp. 249-255
    • Garaj-Vrhovac, V.1    Zeljezic, D.2
  • 49
    • 0026587311 scopus 로고
    • The effect of malathion, an organophosphate, on the plasma FSH, 17 beta-estradiol and progesterone concentrations and acetylcholinesterase activity and conception in dairy cattle
    • Prakash N, Narayana K, Murthy GS, Moudgal NR and Honnegowda: The effect of malathion, an organophosphate, on the plasma FSH, 17 beta-estradiol and progesterone concentrations and acetylcholinesterase activity and conception in dairy cattle. Vet Hum Toxicol 34: 116-119, 1992.
    • (1992) Vet Hum Toxicol , vol.34 , pp. 116-119
    • Prakash, N.1    Narayana, K.2    Murthy, G.S.3    Moudgal, N.R.4    Honnegowda5
  • 50
    • 0031393090 scopus 로고    scopus 로고
    • Temporal effect of methyl parathion on ovarian compensatory hypertrophy, follicular dynamics and estrous cycle in hemicastrated albino rats
    • Asmathbanu I and Kaliwal BB: Temporal effect of methyl parathion on ovarian compensatory hypertrophy, follicular dynamics and estrous cycle in hemicastrated albino rats. J Basic Clin Physiol Pharmacol 8: 237-254, 1997. (Pubitemid 28254959)
    • (1997) Journal of Basic and Clinical Physiology and Pharmacology , vol.8 , Issue.4 , pp. 237-254
    • Asmathbanu, I.1    Kaliwal, B.B.2
  • 51
    • 0030944987 scopus 로고    scopus 로고
    • Inhibition of ovarian compensatory hypertrophy by the administration of methyl parathion in hemicastrated albino rats
    • DOI 10.1016/S0890-6238(96)00199-2, PII S0890623896001992
    • Dhondup P and Kaliwal BB: Inhibition of ovarian compensatory hypertrophy by the administration of methyl parathion in hemicastrated albino rats. Reprod Toxicol 11: 77-84, 1997. (Pubitemid 27152422)
    • (1997) Reproductive Toxicology , vol.11 , Issue.1 , pp. 77-84
    • Dhondup, P.1    Kaliwal, B.B.2
  • 52
    • 0018618783 scopus 로고
    • Effect of 0,0-Dimethyl-0 phosphorothicate (sumithion) on reproductive performance in rats and oestrogenic activity in mice
    • Gouda H and Sastry MS: Effect of 0,0-Dimethyl-0 phosphorothicate (sumithion) on reproductive performance in rats and oestrogenic activity in mice. Indian J Pharmacol 11: 287-292, 1979.
    • (1979) Indian J Pharmacol , vol.11 , pp. 287-292
    • Gouda, H.1    Sastry, M.S.2
  • 54
    • 2542507648 scopus 로고    scopus 로고
    • In vitro studies on the genotoxicity of the organophosphorus insecticide malathion and its two analogues
    • Blasiak J, Jaloszynski P, Trzeciak A and Szyfter K: In vitro studies on the genotoxicity of the organophosphorus insecticide malathion and its two analogues. Mutat Res 445: 275-283, 1999.
    • (1999) Mutat Res , vol.445 , pp. 275-283
    • Blasiak, J.1    Jaloszynski, P.2    Trzeciak, A.3    Szyfter, K.4
  • 55
    • 0027422010 scopus 로고
    • Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion
    • Berkman CE, Quinn DA and Thompson CM: Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion. Chem Res Toxicol 6: 724-730, 1993. (Pubitemid 23290027)
    • (1993) Chemical Research in Toxicology , vol.6 , Issue.5 , pp. 724-730
    • Berkman, C.E.1    Quinn, D.A.2    Thompson, C.M.3
  • 56
    • 34248531130 scopus 로고    scopus 로고
    • Gene expression signature of parathion-transformed human breast epithelial cells
    • Calaf GM and Roy D: Gene expression signature of parathion-transformed human breast epithelial cells. Int J Mol Med 19: 741-750, 2007.
    • (2007) Int J Mol Med , vol.19 , pp. 741-750
    • Calaf, G.M.1    Roy, D.2
  • 57
    • 0034895979 scopus 로고    scopus 로고
    • P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma
    • Elsaleh H, Powell B, McCaul K, Grieu F, Grant R, Joseph D and Iacopetta B: P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. Clin Cancer Res 7: 1343-1349, 2001. (Pubitemid 32708690)
    • (2001) Clinical Cancer Research , vol.7 , Issue.5 , pp. 1343-1349
    • Elsaleh, H.1    Powell, B.2    McCaul, K.3    Grieu, F.4    Grant, R.5    Joseph, D.6    Iacopetta, B.7
  • 60
    • 0028029115 scopus 로고
    • Allele loss and point mutation in codons 12 and 61 of the c-Ha-ras oncogene in carcinogen-transformed human breast epithelial cells
    • Zhang PL, Calaf G and Russo J: Allele loss and point mutation in codons 12 and 61 of the c-Ha-ras oncogene in carcinogen-transformed human breast epithelial cells. Mol Carcinog 9: 46-56, 1994. (Pubitemid 24061285)
    • (1994) Molecular Carcinogenesis , vol.9 , Issue.1 , pp. 46-56
    • Zhang, P.-L.1    Calaf, G.2    Russo, J.3
  • 61
    • 33644822144 scopus 로고    scopus 로고
    • Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene
    • Calaf GM, Alvarado ME and Hei TK: Oncoprotein expression and morphological phenotypes of human breast epithelial cells transformed by the c-Ha-ras oncogene. Oncol Rep 14: 885-893, 2005.
    • (2005) Oncol Rep , vol.14 , pp. 885-893
    • Calaf, G.M.1    Alvarado, M.E.2    Hei, T.K.3
  • 63
    • 0028331099 scopus 로고
    • Early mutational activation on the c-Ki-ras oncogene in endometrial carcinoma
    • Duggan BD, Felix JC, Muderspach LI, Tsao JL and Shibata DK: Early mutational activation on the c-Ki-ras oncogene in endometrial carcinoma. Cancer Res 54: 1604-1607, 1994.
    • (1994) Cancer Res , vol.54 , pp. 1604-1607
    • Duggan, B.D.1    Felix, J.C.2    Muderspach, L.I.3    Tsao, J.L.4    Shibata, D.K.5
  • 64
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • DOI 10.1038/nrc2109, PII NRC2109
    • Schubbert S, Shannon K and Bollag G: Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7: 295-308, 2007. (Pubitemid 46480970)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.