Tissue-engineered skin substitutes in regenerative medicine

Current Opinion in Biotechnology

Volumn 20, Issue 5, 2009, Pages 563-567

  Mansbridge, Jonathan N ^a  

^a Tecellact LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGENEIC CELLS; AUTOLOGOUS CELL; CELLULAR TISSUE; EXPERIMENTAL MODELS; GENETICALLY MODIFIED; HAIR FOLLICLES; IN-VITRO; ISOLATED CELLS; KERATINOCYTES; PATHOLOGICAL CONDITIONS; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE; TISSUE-ENGINEERED SKIN SUBSTITUTES;

ANIMALS; TISSUE;

SKIN;

AGING; CELL DIFFERENTIATION; DNA MODIFICATION; EPIDERMIS; EXPERIMENTAL MODEL; GENETIC TRANSFECTION; HAIR GROWTH; HUMAN; KERATINOCYTE; LIMB REGENERATION; NONHUMAN; ORGANOGENESIS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SKIN GRAFT; SKIN TRANSPLANTATION; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TISSUE REPAIR; WOUND CARE;

ANIMALS; GENE TRANSFER TECHNIQUES; HUMANS; REGENERATION; SKIN; SKIN PHYSIOLOGICAL PHENOMENA; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING;

ANIMALIA; SALAMANDROIDEA;

EID: 70449672970     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2009.08.008     Document Type: Review

References (37)

1. Lysaght M.J., Jaklenec A., and Deweerd E. Great expectations: private sector activity in tissue engineering, regenerative medicine, and stem cell therapeutics. Tissue Eng Part A 14 (2008) 305-315
2. Zhang X., Deng Z., Wang H., Yang Z., Guo W., Li Y., Ma D., Yu C., Zhang Y., and Jin Y. Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration. Biomaterials 30 (2009) 2666-2674
3. Scuderi N., Onesti M.G., Bistoni G., Ceccarelli S., Rotolo S., Angeloni A., and Marchese C. The clinical application of autologous bioengineered skin based on a hyaluronic acid scaffold. Biomaterials 29 (2008) 1620-1629
4. Badiavas E.V., and Falanga V. Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol 139 (2003) 510-516
5. Yoshikawa T., Mitsuno H., Nonaka I., Sen Y., Kawanishi K., Inada Y., Takakura Y., Okuchi K., and Nonomura A. Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg 121 (2008) 860-877
6. Trottier V., Marceau-Fortier G., Germain L., Vincent C., and Fradette J. IFATS collection: using human adipose-derived stem/stromal cells for the production of new skin substitutes. Stem Cells 26 (2008) 2713-2723
7. Xie J.L., Li T.Z., Qi S.H., Huang B., Chen X.G., and Chen J.D. A study of using tissue-engineered skin reconstructed by candidate epidermal stem cells to cover the nude mice with full-thickness skin defect. J Plast Reconstr Aesthet Surg 60 (2007) 983-990
8. Larouche D., Paquet C., Fradette J., Carrier P., Auger F.A., and Germain L. Regeneration of skin and cornea by tissue engineering. Methods Mol Biol 482 (2009) 233-256
9. Kalyanaraman B., Supp D.M., and Boyce S.T. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue Eng Part A 14 (2008) 583-593
10. Hernon C.A., Harrison C.A., Thornton D.J., and MacNeil S. Enhancement of keratinocyte performance in the production of tissue-engineered skin using a low-calcium medium. Wound Repair Regen 15 (2007) 718-726
11. Hu S., Kirsner R.S., Falanga V., Phillips T., and Eaglstein W.H. Evaluation of Apligraf persistence and basement membrane restoration in donor site wounds: a pilot study. Wound Repair Regen 14 (2006) 427-433
12. Barrandon Y., and Green H. Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci U S A 84 (1987) 2302-2306
13. Wood F.M., Stoner M.L., Fowler B.V., and Fear M.W. The use of a non-cultured autologous cell suspension and Integra dermal regeneration template to repair full-thickness skin wounds in a porcine model: a one-step process. Burns 33 (2007) 693-700. This paper describes the use of sprayed keratinocytes for the treatment of severely burned patients.
14. Yang C.-C., Shih T.-S., Chu T.-A., Hsu W.-S., Kuo S.-Y., and Chao Y.-F. The intermingled transplantation of auto- and homografts in severe burns. Burns (1980) 6
15. Di Nunzio F., Maruggi G., Ferrari S., Di Iorio E., Poletti V., Garcia M., Del Rio M., De Luca M., Larcher F., Pellegrini G., et al. Correction of laminin-5 deficiency in human epidermal stem cells by transcriptionally targeted lentiviral vectors. Mol Ther 16 (2008) 1977-1985
16. Mavilio F., Pellegrini G., Ferrari S., Di Nunzio F., Di Iorio E., Recchia A., Maruggi G., Ferrari G., Provasi E., Bonini C., et al. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med 12 (2006) 1397-1402
17. Tian J., Lei P., Laychock S.G., and Andreadis S.T. Regulated insulin delivery from human epidermal cells reverses hyperglycemia. Mol Ther 16 (2008) 1146-1153
18. Thomas-Virnig C.L., Centanni J.M., Johnston C.E., He L.K., Schlosser S.J., Van Winkle K.F., Chen R., Gibson A.L., Szilagyi A., Li L., et al. Inhibition of multidrug-resistant Acinetobacter baumannii by nonviral expression of hCAP-18 in a bioengineered human skin tissue. Mol Ther 17 (2009) 562-569
19. Essner J.J., McIvor R.S., and Hackett P.B. Awakening gene therapy with sleeping beauty transposons. Curr Opin Pharmacol 5 (2005) 513-519
20. Ortiz-Urda S., Thyagarajan B., Keene D.R., Lin Q., Calos M.P., and Khavari P.A. PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa. Hum Gene Ther 14 (2003) 923-928
21. Taichman L.B. Systemic replacement therapy from genetically modified epidermal keratinocytes. Proc Assoc Am Phys 111 (1999) 206-210
22. Huttner N.A., Girod A., Schnittger S., Schoch C., Hallek M., and Buning H. Analysis of site-specific transgene integration following cotransduction with recombinant adeno-associated virus and a rep encoding plasmid. J Gene Med 5 (2003) 120-129
23. Le Bec C., and Douar A.M. Gene therapy progress and prospects-vectorology: design and production of expression cassettes in AAV vectors. Gene Ther 13 (2006) 805-813
24. Allen-Hoffmann B.L., Schlosser S.J., Ivarie C.A., Sattler C.A., Meisner L.F., and O'Connor S.L. Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS. J Invest Dermatol 114 (2000) 444-455
25. Schurr M.J., Foster K.N., Centanni J.M., Comer A.R., Wicks A., Gibson A.L., Thomas-Virnig C.L., Schlosser S.J., Faucher L.D., Lokuta M.A., et al. Phase I/II clinical evaluation of StrataGraft: a consistent, pathogen-free human skin substitute. J Trauma 66 (2009) 866-873 discussion 873-864. This is the first description of clinical trials with non-tumorigenic immortal keratinocytes, which has the potential to be developed into a genetically modified device as described in reference [18].
26. Jean J., Lapointe M., Soucy J., and Pouliot R. Development of an in vitro psoriatic skin model by tissue engineering. J Dermatol Sci 53 (2009) 19-25
27. Pageon H., Techer M.P., and Asselineau D. Reconstructed skin modified by glycation of the dermal equivalent as a model for skin aging and its potential use to evaluate anti-glycation molecules. Exp Gerontol 43 (2008) 584-588
28. Bernerd F., Asselineau D., Vioux C., Chevallier-Lagente O., Bouadjar B., Sarasin A., and Magnaldo T. Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro. Proc Natl Acad Sci U S A 98 (2001) 7817-7822
29. Bernerd F., and Asselineau D. An organotypic model of skin to study photodamage and photoprotection in vitro. J Am Acad Dermatol 58 (2008) S155-159
30. Zheng Y., Du X., Wang W., Boucher M., Parimoo S., and Stenn K. Organogenesis from dissociated cells: generation of mature cycling hair follicles from skin-derived cells. J Invest Dermatol 124 (2005) 867-876
31. Havlickova B., Biro T., Mescalchin A., Tschirschmann M., Mollenkopf H., Bettermann A., Pertile P., Lauster R., Bodo E., and Paus R. A human folliculoid microsphere assay for exploring epithelial-mesenchymal interactions in the human hair follicle. J Invest Dermatol 129 (2009) 972-983. The article describes an in vitro system capable of examining cell differentiation related to hair growth, cytokine secretion and the effects of chemical factors on the process.
32. Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676
33. Soldner F., Hockemeyer D., Beard C., Gao Q., Bell G.W., Cook E.G., Hargus G., Blak A., Cooper O., Mitalipova M., et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136 (2009) 964-977
34. Page R.L., Ambady S., Holmes W.F., Vilner L., Kole D., Kashpur O., Huntress V., Vojtic I., Whitton H., and Dominko T. Induction of stem cell gene expression in adult human fibroblasts without transgenes. Cloning Stem Cells (2009) Jul 21. [Epub ahead of print]
35. Zhou H., Wu S., Joo J.Y., Zhu S., Han D.W., Lin T., Trauger S., Bien G., Yao S., Zhu Y., et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4 (2009) 381-384. This article demonstrates the feasibility of generating induced pluripotent cells, with embryonic stem cell-like properties using recombinant proteins and opens the door to in situ induced stem cells. They obtain a low efficiently of induction but make the point that this is likely to be improved using small molecules and other techniques.
36. Chen S., Do J.T., Zhang Q., Yao S., Yan F., Peters E.C., Scholer H.R., Schultz P.G., and Ding S. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A 103 (2006) 17266-17271
37. Ding S., and Schultz P.G. Small molecules and future regenerative medicine. Curr Top Med Chem 5 (2005) 383-395