Mathematical description of drug movement into tumor with EPR effect and estimation of its configuration for DDS

Colloids and Surfaces B: Biointerfaces

Volumn 75, Issue 1, 2010, Pages 42-46

  Hara, Toshihide ^a   Iriyama, Satoshi ^a   Makino, Kimiko ^a   Terada, Hiroshi ^a   Ohya, Masanori ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Drug disposition; Drug shape; EPR effect; Mathematical modeling; Simulation

Indexed keywords

DRUG DELIVERY SYSTEM; EPR EFFECT; MATHEMATICAL DESCRIPTIONS; MATHEMATICAL MODELING; PRESENT STAGE; SIDE EFFECT; TECHNIQUES USED; TUMOR TISSUES;

BLOOD VESSELS; DRUG DELIVERY; ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ONCOLOGY; PARAMAGNETIC RESONANCE; QUANTUM THEORY; SIMULATORS; TUMORS;

DRUG DOSAGE;

ARTICLE; BLOOD VESSEL; CANCER THERAPY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG PENETRATION; DRUG TRANSPORT; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PARTICLE SIZE; PRIORITY JOURNAL; PROBABILITY; SIMULATION;

ANTINEOPLASTIC AGENTS; CAPILLARIES; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; DRUG DESIGN; MODELS, CHEMICAL; MONONUCLEAR PHAGOCYTE SYSTEM; NEOPLASMS; PERMEABILITY;

EID: 70449646515     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2009.08.013     Document Type: Article

References (13)

1. J.M. Harris, S. Zalipsky Ed., Poly (Ethylene Glycol) Chemistry and Biological Application, ACS Symposium Series 680, American Chemical Society, Washington, DC, 1997.
2. Maeda H. Adv. Drug Deliv. Rev. 6 (1991) 181
3. Maeda H. J. Control. Release 19 (1992) 315
4. Maeda H., Wu J., Sawa T., Matsumura Y., and Hori K. J. Control. Release 65 (2000) 271
5. Maeda H., Sawa T., and Konno T. J. Control. Release 74 (2001) 47
6. Rose P.G., Blessing J.A., Lele S., and Abulafia O. Gynecol. Oncol. 102 (2006) 210
7. Frenkel V., Etherington A., Greene M., Quijiano J., Xie J., Hunter F., Dromi S., and Li K.C.P. Acad. Radiol. 13 (2006) 469
8. Ibrahim N.K., Desai N., Legha S., Shiong P.S., Theriault R.L., Rivera E., Esmaeli B., Ring S.E., Bedikian A., Hortobagyi G.N., and Ellerhorst J.A. Clin. Cancer Res. 8 (2002) 1038
9. Ibrahim N.K., Samuels B., Page R., Doval D., Patel K.M., Rao S.C., Naie M.K., Bhar P., Desai N., and Hortobagyi G.N. J. Clin. Oncol. 23 (2005) 6019
10. Peter E. Kloeden, Eckhard Platen (Eds.), Numerical Solution of Stochastic Differential Equations, Springer, 1992.
11. Uchiyama K., Nagayasu A., Yamagiwa Y., Nishida T., Harashima H., and Kiwada H. Int. J. Pharm. 121 (1995) 195
12. Tortora, and Derrickson. Principles of Anatomy and Physiology. 11th edition (2005), John Wiley & Sons Inc.
13. Mchedlishvili G., and Maeda N. Jpn. J. Physiol. 51 (2001) 19