A meta-analysis evaluating the impact of chitosan on serum lipids in hypercholesterolemic patients

Annals of Nutrition and Metabolism

Volumn 55, Issue 4, 2009, Pages 368-374

  Baker, William L ^a,c   Tercius, Alix ^b   Anglade, Moise ^b   White, C Michael ^a,c   Coleman, Craig I ^a,c  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^c HARTFORD HOSPITAL   (United States)

Author keywords

Chitin; Chitosan; Hypercholesterolemia; Meta analysis

Indexed keywords

CHITOSAN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; DRUG EFFICACY; HUMAN; HYPERCHOLESTEROLEMIA; INFORMATION RETRIEVAL; LIPID BLOOD LEVEL; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTEMATIC REVIEW; TRIACYLGLYCEROL BLOOD LEVEL;

ANTICHOLESTEREMIC AGENTS; CHITOSAN; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; HUMANS; HYPERCHOLESTEROLEMIA; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 70449629783     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000258633     Document Type: Article

References (21)

1. National Cholesterol Education Program (NCEP): Third report of the NCEP Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Heart Lung and Blood Institute 2002. Available at: http://www.nhlbi.nih.gov/guidelines/choleste rol/atp3-rpt.htm
2. Tapola NS, Lyyra ML, Kolehmainen RM, Sarkkinen ES, Schauss AG: Safety aspects and cholesterol-lowering efficacy of chitosan tablets. J Am Coll Nutr 2008; 27: 22-30.
3. Liao FH, Shieh MJ, Chang NC, Chien YW: Chitosan supplementation lowers serum lipids and maintains normal calcium, magnesium, and iron status in hyperlipidemic patients. Nutr Res 2007; 27: 146-151.
4. Jaffer S, Sampalis JS: Efficacy and safety of chitosan HEP-40 TM in the management of hypercholesterolemia: a randomized, multicenter, placebo-controlled trial. Altern Med Rev 2007; 12: 265-273.
5. Bokura H, Kobayashi S: Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 2003; 57: 721-725.
6. Metso S, Ylitalo R, Nikkila M, Wuolijoki E, Ylitalo P, Lehtimaki T: The effects of longterm microcrystalline chitosan therapy on plasma lipids and glucose concentrations in subjects with increased plasma total cholesterol: a randomized placebo-controlled double-blind crossover trial in healthy men and women. Eur J Clin Pharmacol 2003; 59: 741-746.
7. Ho SC, Tai ES, Eng PHK, Tan CE, Fok ACK: In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects. Singapore Med J 2001; 42: 6-10.
8. Ni Mhurchu C Dunshea-Mooij CA Bennett D Rodgers A:Chitosan for overweight or obesity,Cochrane Database Syst Rev,2005,20, Art. No: CD003892. DOI: 10.1002/14651858.CD003892.p
9. Higgins JPT, Green S (updated February 2008): Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0. The Cochrane Collaboration. Available from www.cochrane-handbook.org.
10. Wong SS, Wilczynski NL, Haynes RB: Comparison of top-performing search strategies for detecting clinically sound treatment studies and systematic reviews in MEDLINE and EMBASE. J Med Libr Assoc 2006; 94: 451-455.
11. DerSimonian R, Laird N: Meta-Analysis in clinical trials. Control Clin Trials 1986; 7: 177-188.
12. Follmann D, Elliott P, Suh I, Cutler J: Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 1992; 45: 769-773.
13. Edwards JE, Moore RA: Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomized, double blind trials. BMC Fam Pract 2003; 4: 1-19.
14. Arvill A, Bodin L: Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Am J Clin Nutr 1995; 61: 585-589.
15. Brown L, Rosner B, Willett WW, Sacks FM: Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999; 69: 30-42.
16. Sharma RD, Raghuram TC, Rao NS: Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990; 44: 301-306.
17. Preuss HG, Garis RI, Bramble JD, Bagchi D, Bagchi M, Rao CV, Satyanarayana S: Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. Int J Clin Pharmacol Res 2005; 25: 133-144. (Pubitemid 41719437)
18. Afkhami-Ardekani M, Shojaoddiny-Ardekani A: Effect of vitamin C on blood glucose, serum lipids and serum insulin in type 2 diabetes patients. Indian J Med Res 2007; 126: 471-474.
19. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497.
20. Bravata DM, Sanders L, Huang J, Krumholz HM, Olkin I, Gardner CD, Bravata DM: Efficacy and safety of low-carbohydrate diets. A systematic review. JAMA 2003; 289: 1837-1850.
21. Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Vinyoles E, Arós F, Conde M, Lahoz C, Lapetra J, Sáez G, Ros E: Effects of a Mediterranean-style diet on cardiovascular risk factors. A randomized trial. Ann Intern Med 2006; 145: 1-11.