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Volumn 9, Issue , 2009, Pages 361-

Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANGIOGENIC FACTOR; ANGIOPOIETIN 1; ANGIOPOIETIN 2; FLUOROURACIL; LIPOCORTIN 5; VASCULOTROPIN;

EID: 70449627138     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-361     Document Type: Article
Times cited : (26)

References (54)
  • 1
    • 0036189111 scopus 로고    scopus 로고
    • Prognostic prediction and treatment strategy in hepatocellular carcinoma
    • 10.1053/jhep.2002.32089, 11870363
    • Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002, 35:519-524. 10.1053/jhep.2002.32089, 11870363.
    • (2002) Hepatology , vol.35 , pp. 519-524
    • Bruix, J.1    Llovet, J.M.2
  • 2
    • 0026071402 scopus 로고
    • Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression
    • Shen DW, Lu YG, Chin KV, Pastan I, Gottesman MM. Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression. J Cell Sci 1991, 98:317-322.
    • (1991) J Cell Sci , vol.98 , pp. 317-322
    • Shen, D.W.1    Lu, Y.G.2    Chin, K.V.3    Pastan, I.4    Gottesman, M.M.5
  • 3
    • 36448942509 scopus 로고    scopus 로고
    • Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules
    • Nagano H, Miyamoto A, Wada H, Ota H, Marubashi S, Takeda Y, Dono K, Umeshita K, Sakon M, Monden M. Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules. Cancer 2007, 110(11):1054-1058.
    • (2007) Cancer , vol.110 , Issue.11 , pp. 1054-1058
    • Nagano, H.1    Miyamoto, A.2    Wada, H.3    Ota, H.4    Marubashi, S.5    Takeda, Y.6    Dono, K.7    Umeshita, K.8    Sakon, M.9    Monden, M.10
  • 5
    • 33646383886 scopus 로고    scopus 로고
    • Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion
    • 10.1002/cncr.21832, 16565970
    • Obi S, Yoshida H, Toune R, Unuma T, Kanda M, Sato S, Tateishi R, Teratani T, Shiina S, Omata M. Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion. Cancer 2006, 106:1990-1997. 10.1002/cncr.21832, 16565970.
    • (2006) Cancer , vol.106 , pp. 1990-1997
    • Obi, S.1    Yoshida, H.2    Toune, R.3    Unuma, T.4    Kanda, M.5    Sato, S.6    Tateishi, R.7    Teratani, T.8    Shiina, S.9    Omata, M.10
  • 6
    • 26944439521 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression
    • 10.1038/sj.bjc.6602742, 2361594, 16106266
    • Ota H, Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Nakamura M, Damdinsuren B, Wada H, Marubashi S, Miyamoto A, Dono K, Umeshita K, Nakamori S, Wakasa K, Monden M. Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. Br J Cancer 2005, 93:557-564. 10.1038/sj.bjc.6602742, 2361594, 16106266.
    • (2005) Br J Cancer , vol.93 , pp. 557-564
    • Ota, H.1    Nagano, H.2    Sakon, M.3    Eguchi, H.4    Kondo, M.5    Yamamoto, T.6    Nakamura, M.7    Damdinsuren, B.8    Wada, H.9    Marubashi, S.10    Miyamoto, A.11    Dono, K.12    Umeshita, K.13    Nakamori, S.14    Wakasa, K.15    Monden, M.16
  • 7
    • 0028362516 scopus 로고
    • The interferons: a biological system with therapeutic potential in viral infections
    • 10.1016/0166-3542(94)90058-2, 7526796
    • Baron S, Dianzani F. The interferons: a biological system with therapeutic potential in viral infections. Antiviral Res 1994, 24:97-110. 10.1016/0166-3542(94)90058-2, 7526796.
    • (1994) Antiviral Res , vol.24 , pp. 97-110
    • Baron, S.1    Dianzani, F.2
  • 8
    • 0028117299 scopus 로고
    • Cytokine therapeutics: lessons from interferon alpha
    • 10.1073/pnas.91.4.1198, 43124, 8108387
    • Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci USA 1994, 91:1198-1205. 10.1073/pnas.91.4.1198, 43124, 8108387.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1198-1205
    • Gutterman, J.U.1
  • 9
    • 0028051363 scopus 로고
    • Role of interferons in the regulation of cell proliferation, differentiation, and development
    • 10.1002/mrd.1080390216, 7530016
    • Hertzog PJ, Hwang SY, Kola I. Role of interferons in the regulation of cell proliferation, differentiation, and development. Mol Reprod Dev 1994, 39:226-232. 10.1002/mrd.1080390216, 7530016.
    • (1994) Mol Reprod Dev , vol.39 , pp. 226-232
    • Hertzog, P.J.1    Hwang, S.Y.2    Kola, I.3
  • 10
    • 0026600296 scopus 로고
    • Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells
    • 10.1016/0006-291X(92)91863-L, 1540167
    • Schwartz EL, Hoffman M, O'Connor CJ, Wadler S. Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells. Biochem Biophys Res Commun 1992, 182:1232-1239. 10.1016/0006-291X(92)91863-L, 1540167.
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1232-1239
    • Schwartz, E.L.1    Hoffman, M.2    O'Connor, C.J.3    Wadler, S.4
  • 11
    • 1542753740 scopus 로고    scopus 로고
    • Interferon-beta is more potent than interferon-alpha in inhibition of human hepatocellular carcinoma cell growth when used alone and in combination with anticancer drugs
    • 10.1245/ASO.2003.03.010, 14654475
    • Damdinsuren B, Nagano H, Sakon M, Kondo M, Yamamoto T, Umeshita K, Dono K, Nakamori S, Monden M. Interferon-beta is more potent than interferon-alpha in inhibition of human hepatocellular carcinoma cell growth when used alone and in combination with anticancer drugs. Ann Surg Oncol 2003, 10:1184-1190. 10.1245/ASO.2003.03.010, 14654475.
    • (2003) Ann Surg Oncol , vol.10 , pp. 1184-1190
    • Damdinsuren, B.1    Nagano, H.2    Sakon, M.3    Kondo, M.4    Yamamoto, T.5    Umeshita, K.6    Dono, K.7    Nakamori, S.8    Monden, M.9
  • 12
    • 0033941539 scopus 로고    scopus 로고
    • Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells
    • Eguchi H, Nagano H, Yamamoto H, Miyamoto A, Kondo M, Dono K, Nakamori S, Umeshita K, Sakon M, Monden M. Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells. Clin Cancer Res 2000, 6:2881-2890.
    • (2000) Clin Cancer Res , vol.6 , pp. 2881-2890
    • Eguchi, H.1    Nagano, H.2    Yamamoto, H.3    Miyamoto, A.4    Kondo, M.5    Dono, K.6    Nakamori, S.7    Umeshita, K.8    Sakon, M.9    Monden, M.10
  • 18
    • 0038666255 scopus 로고    scopus 로고
    • Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice
    • Solorzano CC, Hwang R, Baker CH, Bucana CD, Pisters PW, Evans DB, Killion JJ, Fidler IJ. Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. Clin Cancer Res 2003, 9:1858-1867.
    • (2003) Clin Cancer Res , vol.9 , pp. 1858-1867
    • Solorzano, C.C.1    Hwang, R.2    Baker, C.H.3    Bucana, C.D.4    Pisters, P.W.5    Evans, D.B.6    Killion, J.J.7    Fidler, I.J.8
  • 19
    • 0029075603 scopus 로고
    • Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas
    • 10.1073/pnas.92.10.4562, 41984, 7753843
    • Singh RK, Gutman M, Bucana CD, Sanchez R, Llansa N, Fidler IJ. Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci USA 1995, 92:4562-4566. 10.1073/pnas.92.10.4562, 41984, 7753843.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4562-4566
    • Singh, R.K.1    Gutman, M.2    Bucana, C.D.3    Sanchez, R.4    Llansa, N.5    Fidler, I.J.6
  • 20
    • 0027990348 scopus 로고
    • Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal-carcinoma cells
    • 10.1002/ijc.2910580313, 8050821
    • Gohji K, Fidler IJ, Tsan R, Radinsky R, von Eschenbach AC, Tsuruo T, Nakajima M. Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal-carcinoma cells. Int J Cancer 1994, 58:380-384. 10.1002/ijc.2910580313, 8050821.
    • (1994) Int J Cancer , vol.58 , pp. 380-384
    • Gohji, K.1    Fidler, I.J.2    Tsan, R.3    Radinsky, R.4    von Eschenbach, A.C.5    Tsuruo, T.6    Nakajima, M.7
  • 22
    • 0026756731 scopus 로고
    • Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon
    • 10.1073/pnas.89.19.9049, 50062, 1409601
    • Oliveira IC, Sciavolino PJ, Lee TH, Vilcek J. Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon. Proc Natl Acad Sci USA 1992, 89:9049-9053. 10.1073/pnas.89.19.9049, 50062, 1409601.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9049-9053
    • Oliveira, I.C.1    Sciavolino, P.J.2    Lee, T.H.3    Vilcek, J.4
  • 24
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 25
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • 10.1038/nm0195-27, 7584949
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995, 1:27-31. 10.1038/nm0195-27, 7584949.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 26
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • 10.1016/S0092-8674(00)80108-7, 8756718
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364. 10.1016/S0092-8674(00)80108-7, 8756718.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 27
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • 10.1038/35025220, 11001068
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257. 10.1038/35025220, 11001068.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 28
    • 0031803599 scopus 로고    scopus 로고
    • Prospective randomized trial of two dose levels of interferon alfa with zidovudine for the treatment of Kaposi's sarcoma associated with human immunodeficiency virus infection: a Canadian HIV Clinical Trials Network study
    • Shepherd FA, Beaulieu R, Gelmon K, Thuot CA, Sawka C, Read S, Singer J. Prospective randomized trial of two dose levels of interferon alfa with zidovudine for the treatment of Kaposi's sarcoma associated with human immunodeficiency virus infection: a Canadian HIV Clinical Trials Network study. J Clin Oncol 1998, 16:1736-1742.
    • (1998) J Clin Oncol , vol.16 , pp. 1736-1742
    • Shepherd, F.A.1    Beaulieu, R.2    Gelmon, K.3    Thuot, C.A.4    Sawka, C.5    Read, S.6    Singer, J.7
  • 29
    • 0031052085 scopus 로고    scopus 로고
    • Successful management with interferon alpha-2a after prednisone therapy failure in an infant with a giant cavernous hemangioma
    • 10.1002/(SICI)1096-911X(199703)28:3<213::AID-MPO12>3.0.CO;2-F, 9024520
    • Castello MA, Ragni G, Antimi A, Todini A, Patti G, Lubrano R, Clerico A, Calisti A. Successful management with interferon alpha-2a after prednisone therapy failure in an infant with a giant cavernous hemangioma. Med Pediatr Oncol 1997, 28:213-215. 10.1002/(SICI)1096-911X(199703)28:3<213::AID-MPO12>3.0.CO;2-F, 9024520.
    • (1997) Med Pediatr Oncol , vol.28 , pp. 213-215
    • Castello, M.A.1    Ragni, G.2    Antimi, A.3    Todini, A.4    Patti, G.5    Lubrano, R.6    Clerico, A.7    Calisti, A.8
  • 30
    • 0035134688 scopus 로고    scopus 로고
    • Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities
    • 10.1634/theoncologist.6-1-34, 11161227
    • Jonasch E, Haluska FG. Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities. Oncologist 2001, 6:34-55. 10.1634/theoncologist.6-1-34, 11161227.
    • (2001) Oncologist , vol.6 , pp. 34-55
    • Jonasch, E.1    Haluska, F.G.2
  • 31
    • 0033902039 scopus 로고    scopus 로고
    • Efficient inhibition of in vivo human malignant glioma growth and angiogenesis by interferon-beta treatment at early stage of tumor development
    • Hong YK, Chung DS, Joe YA, Yang YJ, Kim KM, Park YS, Yung WK, Kang JK. Efficient inhibition of in vivo human malignant glioma growth and angiogenesis by interferon-beta treatment at early stage of tumor development. Clin Cancer Res 2000, 6:3354-3360.
    • (2000) Clin Cancer Res , vol.6 , pp. 3354-3360
    • Hong, Y.K.1    Chung, D.S.2    Joe, Y.A.3    Yang, Y.J.4    Kim, K.M.5    Park, Y.S.6    Yung, W.K.7    Kang, J.K.8
  • 33
    • 0033529122 scopus 로고    scopus 로고
    • Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins
    • 10.1038/sj.onc.1202609, 10362250
    • Sangfelt O, Erickson S, Castro J, Heiden T, Gustafsson A, Einhorn S, Grander D. Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins. Oncogene 1999, 18:2798-2810. 10.1038/sj.onc.1202609, 10362250.
    • (1999) Oncogene , vol.18 , pp. 2798-2810
    • Sangfelt, O.1    Erickson, S.2    Castro, J.3    Heiden, T.4    Gustafsson, A.5    Einhorn, S.6    Grander, D.7
  • 34
    • 0017414246 scopus 로고
    • Interferon suppresses the transition of quiescent 3T3 cells to a growing state
    • 10.1038/268236a0, 887154
    • Sokawa Y, Watanabe Y, Watanabe Y, Kawade Y. Interferon suppresses the transition of quiescent 3T3 cells to a growing state. Nature 1977, 268:236-238. 10.1038/268236a0, 887154.
    • (1977) Nature , vol.268 , pp. 236-238
    • Sokawa, Y.1    Watanabe, Y.2    Watanabe, Y.3    Kawade, Y.4
  • 35
    • 0028177842 scopus 로고
    • Interferon-alpha inhibits cyclin E- and cyclin D1-dependent CDK-2 kinase activity associated with RB protein and E2F in Daudi cells
    • 10.1006/bbrc.1994.1479, 8166726
    • Zhang K, Kumar R. Interferon-alpha inhibits cyclin E- and cyclin D1-dependent CDK-2 kinase activity associated with RB protein and E2F in Daudi cells. Biochem Biophys Res Commun 1994, 200:522-528. 10.1006/bbrc.1994.1479, 8166726.
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 522-528
    • Zhang, K.1    Kumar, R.2
  • 36
    • 0032991093 scopus 로고    scopus 로고
    • Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines
    • 10.1002/hep.510290624, 10347112
    • Yano H, Iemura A, Haramaki M, Ogasawara S, Takayama A, Akiba J, Kojiro M. Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines. Hepatology 1999, 29:1708-1717. 10.1002/hep.510290624, 10347112.
    • (1999) Hepatology , vol.29 , pp. 1708-1717
    • Yano, H.1    Iemura, A.2    Haramaki, M.3    Ogasawara, S.4    Takayama, A.5    Akiba, J.6    Kojiro, M.7
  • 37
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications
    • 10.1634/theoncologist.5-suppl_1-11, 10804085
    • Ellis LM, Takahashi Y, Liu W, Shaheen RM. Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. Oncologist 2000, 5:11-15. 10.1634/theoncologist.5-suppl_1-11, 10804085.
    • (2000) Oncologist , vol.5 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3    Shaheen, R.M.4
  • 38
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • 10.1126/science.2479986, 2479986
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246:1306-1309. 10.1126/science.2479986, 2479986.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 39
    • 0032963472 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
    • 1850007, 10027396
    • Nor JE, Christensen J, Mooney DJ, Polverini PJ. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 1999, 154:375-384. 1850007, 10027396.
    • (1999) Am J Pathol , vol.154 , pp. 375-384
    • Nor, J.E.1    Christensen, J.2    Mooney, D.J.3    Polverini, P.J.4
  • 40
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogenic growth factors and their inhibitors
    • 10.1038/70928, 10581076
    • Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 1999, 5:1359-1364. 10.1038/70928, 10581076.
    • (1999) Nat Med , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 41
    • 0042882883 scopus 로고    scopus 로고
    • Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches
    • 10.1097/00000658-200307000-00003, 1422670, 12832961
    • Poon RT, Fan ST, Wong J. Clinical significance of angiogenesis in gastrointestinal cancers: a target for novel prognostic and therapeutic approaches. Ann Surg 2003, 238:9-28. 10.1097/00000658-200307000-00003, 1422670, 12832961.
    • (2003) Ann Surg , vol.238 , pp. 9-28
    • Poon, R.T.1    Fan, S.T.2    Wong, J.3
  • 44
    • 0030480322 scopus 로고    scopus 로고
    • Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    • 10.1016/S0092-8674(00)81813-9, 8980224
    • Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996, 87:1171-1180. 10.1016/S0092-8674(00)81813-9, 8980224.
    • (1996) Cell , vol.87 , pp. 1171-1180
    • Suri, C.1    Jones, P.F.2    Patan, S.3    Bartunkova, S.4    Maisonpierre, P.C.5    Davis, S.6    Sato, T.N.7    Yancopoulos, G.D.8
  • 48
    • 0032939205 scopus 로고    scopus 로고
    • Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma
    • 10.1172/JCI4891, 407900, 9927494
    • Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. J Clin Invest 1999, 103:341-345. 10.1172/JCI4891, 407900, 9927494.
    • (1999) J Clin Invest , vol.103 , pp. 341-345
    • Tanaka, S.1    Mori, M.2    Sakamoto, Y.3    Makuuchi, M.4    Sugimachi, K.5    Wands, J.R.6
  • 51
    • 0027479684 scopus 로고
    • Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2
    • 10.1126/science.8438157, 8438157
    • Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science 1993, 259:971-974. 10.1126/science.8438157, 8438157.
    • (1993) Science , vol.259 , pp. 971-974
    • Harada, H.1    Kitagawa, M.2    Tanaka, N.3    Yamamoto, H.4    Harada, K.5    Ishihara, M.6    Taniguchi, T.7
  • 52
    • 0038745370 scopus 로고    scopus 로고
    • Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer
    • Zhang L, Yang N, Park JW, Katsaros D, Fracchioli S, Cao G, O'Brien-Jenkins A, Randall TC, Rubin SC, Coukos G. Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. Cancer Res 2003, 63:3403-3412.
    • (2003) Cancer Res , vol.63 , pp. 3403-3412
    • Zhang, L.1    Yang, N.2    Park, J.W.3    Katsaros, D.4    Fracchioli, S.5    Cao, G.6    O'Brien-Jenkins, A.7    Randall, T.C.8    Rubin, S.C.9    Coukos, G.10
  • 53
    • 33645731313 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis
    • 10.1158/0008-5472.CAN-05-3612, 16585190
    • Battle TE, Lynch RA, Frank DA. Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res 2006, 66:3649-3657. 10.1158/0008-5472.CAN-05-3612, 16585190.
    • (2006) Cancer Res , vol.66 , pp. 3649-3657
    • Battle, T.E.1    Lynch, R.A.2    Frank, D.A.3


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