Loss of hepatocyte-nuclear-factor-4α affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Darsigny, Mathieu ^a,b   Babeu, Jean Philippe ^a,b   Dupuis, Andrée Anne ^a,b   Furth, Emma E ^c   Seidman, Ernest G ^a,d   Lévy, Émile ^a,e   Verdu, Elena F ^f   Gendron, Fernand Pierre ^a,b   Boudreau, François ^a,b  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e UNIVERSITY OF MONTREAL   (Canada)

^f MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CLAUDIN; CLAUDIN 15; CYTOKINE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MUTANT PROTEIN; UNCLASSIFIED DRUG; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL HYPERPLASIA; CELL INFILTRATION; CELL PROLIFERATION; CHRONIC INFLAMMATION; COLITIS; COLON ABSORPTION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENTERITIS; GENE DELETION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE LOSS; IMMUNOCOMPETENT CELL; INTESTINE CRYPT; INTESTINE MUCOSA PERMEABILITY; ION TRANSPORT; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; COLON; DNA MICROARRAY; GENETIC TRANSCRIPTION; HOMEOSTASIS; INFLAMMATION; INTESTINE; METABOLISM; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; COLITIS; COLON; GENE DELETION; HEPATOCYTE NUCLEAR FACTOR 4; HOMEOSTASIS; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTESTINES; ION TRANSPORT; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 70449585192     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007609     Document Type: Article

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