Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 42, 2009, Pages 17916-17920

  Kopp, Sarah J ^a   Banisadr, Ghazal ^a   Glajch, Kelly ^a   Maurer, Ulrike E ^b   Grünewald, Kay ^b   Miller, Richard J ^a   Osten, Pavel ^a   Spear, Patricia G ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

HSV; Pathogenesis

Indexed keywords

HERPESVIRUS ENTRY MEDIATOR; NECTIN 1; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENCEPHALITIS; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INOCULATION; MOUSE; NERVE CELL; NONHUMAN; PARENCHYMA; PATHOGENESIS; PRIORITY JOURNAL; VAGINA EPITHELIUM;

ANIMALS; ANTIGENS, VIRAL; CELL ADHESION MOLECULES; ENCEPHALITIS, HERPES SIMPLEX; FEMALE; HERPESVIRUS 2, HUMAN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; RECEPTORS, VIRUS; VIRUS INTERNALIZATION;

HERPESVIRIDAE; MUS; SIMPLEXVIRUS;

EID: 70449564320     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908892106     Document Type: Article

References (29)

1. Roizman B, Knipe DM, Whitley RJ (2007) in Fields Virology, eds Knipe DM, Howley PM (Lippincott Williams & Wilkins, Philadelphia), pp 2502-2601.
2. Spear PG, Eisenberg RJ, Cohen GH (2000) Three classes of cell surface receptors for alphaherpesvirus entry. Virology 275:1-8.
3. Shukla D, Spear PG (2001) Herpesviruses and heparan sulfate: An intimate relationship in aid of viral entry. J Clin Invest 108:503-510. (Pubitemid 32777727)
4. Spear PG, Longnecker R (2003) Herpesvirus entry: An update. J Virol 77:10179-10185.
5. Satoh T, et al. (2008) PILRa is a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B. Cell 132:935-944.
6. Krummenacher C, et al. (2005) Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry. EMBO J 24:4144-4153. (Pubitemid 41752883)
7. Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC (2006) Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313:217-220. (Pubitemid 44066251)
8. Warner MS, et al. (1998) A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2 and pseudorabies virus. Virology 246:179-189.
9. Krummenacher C, et al. (2004) Comparative usage of herpes virus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus. Virology 322:286-299. (Pubitemid 38521143)
10. Shukla D, Rowe CL, Dong Y, Racaniello VR, Spear PG (1999) The murine homolog (Mph) of human herpesvirus entry protein B (HveB) mediates entry of pseudorabies virus but not herpes simplex virus types 1 and 2. J Virol 73:4493-4497. (Pubitemid 29189903)
11. Shukla D, et al. (1999) A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell 99:13-22. (Pubitemid 29468626)
12. Taylor JM, et al. (2007) Alternative entry receptors for herpes simplex virus and their roles in disease. Cell Host & Microbe 2:1-10.
13. Damasio AR, Van Hoesen W (1985) The limbic system and the localization of herpes simplex encephalitis. J Neurol Neurosurg Psychiatry 48:297-301. (Pubitemid 15109106)
14. Esiri MM (1982) Herpes simplex encephalitis: An immunological study of the distribution of viral antigen within the brain. J Neurol Sci 55:209-219.
15. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ (2004) Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma 21:1017-1030. (Pubitemid 39096852)
16. Milne RSB, Connolly SA, Krummenacher C, Eisenberg RJ, Cohen GH (2001) Porcine HveC, a member of the highly conserved HveC/nectin 1 family, is a functional alpha-herpesvirus receptor. Virology 281:315-328. (Pubitemid 32881147)
17. Haarr L, Shukla D, Rødahl E, Dal Canto MC, Spear PG (2001) Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse. Virology 287:301-309. (Pubitemid 32804016)
18. Richart SM, et al. (2003) Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by nectin-1/HveC. J Virol 77:3307-3311. (Pubitemid 36228115)
19. Simpson SA, et al. (2005) Nectin-1/HveC mediates herpes simplex virus type-1 entry into primary human sensory neurons and fibroblasts. J Neurovirol 11:208-218.
20. Lawrence R, et al. (2007) The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. Matrix Biol 26:442-455. (Pubitemid 47081391)
21. Maurer E, Sodeik B, Grünewald K (2008) Native 3D intermediates of membrane fusion in herpes simplex virus 1 entry. Proc Natl Acad Sci USA 105:10559-10564.
22. Ando Y, Kitayama H, Kawaguchi Y, Koyanagi Y (2008) Primary target cells of herpes simplex virus type 1 in the hippocampus. Microbes and Infection 10:1514-1523.
23. Webb SJ, Eglin RP, Reading M, Esiri MM (1989) Experimental murine herpes simplex encephalitis: Immnohistochemical detection of virus antigens. Neuropathol Appl Neurobiol 15:165-174. (Pubitemid 19107987)
24. McFarland DJ, Hotchin J (1987) Contrasting patterns of virus spread and neuropathology following microinjection of herpes simplex virus into the hippocampus or cerebellum of mice. J Neurol Sci 79:255-265.
25. McFarland DJ, Sikora E, Hotchin J (1986) The production of focal herpes encephalitis in mice by stereotaxic inoculation of virus: Anatomical and behavioral effects. J Neurol Sci 72:307-318. (Pubitemid 16125209)
26. Wang Y, et al. (2005) The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest 115:711-717. (Pubitemid 40322246)
27. Inagaki M, et al. (2005) Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development 132:1525-1537. (Pubitemid 40575855)
28. Cetin A, Komai S, Eliava M, Seeburg PH, Osten P (2006) Stereotaxic gene delivery in the rodent brain. Nature Protocols 1:3166-3173.
29. Paxinos G, Franklin KBJ (2004) in The Mouse Brain in Stereotaxic Coordinates (Elsevier Science, San Diego, CA).