Methylation not a frequent "second hit" in tumors with germline BRCA mutations

Familial Cancer

Volumn 8, Issue 4, 2009, Pages 339-346

  Dworkin, Amy M ^a   Spearman, Andrew D ^a   Tseng, Stephanie Y ^a   Sweet, Kevin ^b   Toland, Amanda Ewart ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

BRCA1; BRCA2; Loss of heterozygosity; Promoter methylation

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ALLELE; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DNA METHYLATION; GERM LINE MUTATION; HETEROZYGOSITY LOSS; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MUTATION; OVARY CANCER; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE; WILD TYPE;

BASE SEQUENCE; BREAST NEOPLASMS; DNA METHYLATION; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; LOSS OF HETEROZYGOSITY; OVARIAN NEOPLASMS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS, GENETIC;

EID: 70449534798     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-009-9240-1     Document Type: Article

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