Thresholds: Absolute, practical, pragmatic, apparent and virtual

Toxicology Letters

Volumn 191, Issue 2-3, 2009, Pages 365-

  Jeffrey, Alan M ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Risk extrapolation; Thresholds

Indexed keywords

HEMOGLOBIN; MESYLIC ACID ETHYL ESTER; VALINE;

ARTIFACT; CHEMICAL CARCINOGENESIS; EXPERIMENTAL DESIGN; GENOTOXICITY; LETTER; LINEAR SYSTEM; MICRONUCLEUS TEST; PRIORITY JOURNAL; REFERENCE VALUE; SIGNAL DETECTION;

ALGORITHMS; ANIMALS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYL METHANESULFONATE; LINEAR MODELS; MICE; MICRONUCLEUS TESTS; MUTAGENS;

EID: 70449525341     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.07.027     Document Type: Letter

References (3)

1. Gocke E., Ballantyne M., Whitwell J., and Muller L. MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU. Toxicol. Lett. (2009) 10.1016/j.toxlet.2009.03.021
2. Haseman J.K. An alternative perspective: a critical evaluation of the Waddell threshold extrapolation model in chemical carcinogenesis. Toxol. Pathol. 31 (2003) 468-470
3. Lutz W.K. Waddell's representation of the tumor incidence data of the ED01 study is strongly misleading. Toxicol. Sci. 75 (2003) 223-224