Study of critical points of drugs with different solubilities in hydrophilic matrices

International Journal of Pharmaceutics

Volumn 383, Issue 1-2, 2010, Pages 138-146

  Fuertes, Inmaculada ^a   Caraballo, Isidoro ^a   Miranda, Antonia ^a   Millán, Mónica ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

HPMC; Hydrophilic matrices; Percolation theory; Percolation threshold; Solubility; Swelling matrices

Indexed keywords

ACICLOVIR; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; LOBENZARIT; PARACETAMOL; RANITIDINE; THEOPHYLLINE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG SOLUBILITY; KINETICS; MATRIX TABLET; OSMOTIC STRESS; POROSITY; PRIORITY JOURNAL; WATER TRANSPORT;

CHEMISTRY, PHARMACEUTICAL; DIFFUSION; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 70449525217     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.09.019     Document Type: Article

References (36)

1. Bettini R., Colombo P., Massimo G., Catellani P.L., and Vitali T. Swelling and drug release hydrogel matrices: polymer viscosity and matrix porosity effect. Eur. J. Pharm. Sci. 2 (1994) 213-219
2. Bettini R., Catellani P.L., Santi P., Massimo G., Peppas N.A., and Colombo P. Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. J. Control Release 70 (2001) 383-391
3. Bonny J.D., and Leuenberger H. Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics. Pharm. Acta Helv. 66 (1991) 160-164
4. Caraballo I., Fernandez-Arévalo M., Holgado M.A., and Rabasco A.M. Percolation theory: application to the study of the release behaviour from inert matrix system. Int. J. Pharm. 96 (1993) 175-181
5. Caraballo I., Fernandez-Arevalo M., Holgado M.A., Rabasco A.M., and Leuenberger H. Study of the release mechanism of carteolol inert matrix tablets on the basis of percolation theory. Int. J. Pharm. 109 (1994) 229-236
6. Caraballo I., Millán M., and Rabasco A.M. Relationship between drug percolation threshold and particle size in matrix tablets. Pharm. Res. 13 (1996) 387-390
7. Caraballo I., Millán M., Rabasco A.M., and Leuenberger H. Zero-order release periods inert matrices. Influence of the distance to the percolation threshold. Pharm. Acta Helv. 71 (1996) 335-339
8. Colombo P., Bettini P.R., Massimo G., Catellani P.L., Santi P., and Peppas N.A. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J. Pharm. Sci. 84 (1995) 991-997
9. Colombo P., Bettini R., Santi P., De Ascentiis A., and Peppas N.A. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J. Control Release 39 (1996) 231-237
10. Davidson III G.W.R., and Peppas N.A. V. Relaxation-controlled transport in P(HEMA-co-MMA) copolymers. J. Control Release 3 (1986) 243-258
11. Espina-Márquez A., and Caraballo I. A new wet conductivimetric method to estimate the drug percolation threshold. Pharm. Res. 21 (2004) 875-881
12. Ford J.L., Rubinstein M.H., Caul Mc., Hogan J.E., and Edgar P.E. Importance of drug type, tablet shape and added diluents on drug release kinetics from hidroxypropylmethylcelluose tablets. Int. J. Pharm. 40 (1987) 223-234
13. Fuertes I., Miranda A., Millán M., and Caraballo I. Estimation of the percolation thresholds in acyclovr hydrophilic matrix tablets. Eur. J. Pharm. Biopharm. 64 (2006) 336-342
14. Pharmaceutical Press and American Pharmaceutical Association. Handbook of Pharmaceutical Excipientes. 4th ed. (2003), Pharmaceutical Press and American Pharmaceutical Association, USA
15. Higuchi T. Mechanism of sustained-action medication-theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52 (1963) 1145-1149
16. Hogan J.E. Hydroxypropylmethylcellulose sustained release technology. Drug Dev. Ind. Pharm. 15 (1989) 975-999
17. Holman L.E., and Leuenberger H. The relationship between solid fraction and mechanical properties of compacts-the percolation theory model approach. Int. J. Pharm. 46 (1988) 35-44
18. ® tablets. Drug Dev. Ind. Pharm. 24 (1998) 645-651
19. Korsmeyer R.W., Gurny R., Doelker E., Buri P., and Peppas N.A. Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm. 15 (1983) 25-35
20. Leuenberger H., Rohera B.D., and Haas C. Percolation theory-a novel approach to solid dosage form design. Int. J. Pharm. 38 (1987) 109-115
21. ® RS-PM matrices. Int. J. Pharm. 170 (1998) 169-177
22. Melgoza L.M., Rabasco A.M., Sandoval H., and Caraballo I. Estimation of the percolation thresholds in dextromethorphan hydrobromide matrices. Eur. J. Pharm. Sci. 12 (2001) 453-459
23. Millán M., Caraballo I., and Rabasco A.M. The role of the drug/excipient particle size ratio in the percolation model for tablets. Pharm. Res. 15 (1998) 216-220
24. Miranda A., Millán M., and Caraballo I. Study of the critical points of HPMC hydrophilic matrices for controlled drug delivery. Int. J. Pharm. 311 (2006) 75-81
25. Miranda A., Millán M., and Caraballo I. Study of the critical points in Lobenzarit disodium hydrophilic matrices for controlled drug delivery. Chem. Pharm. Bull. 54 (2006) 598-602
26. Miranda A., Millán M., and Caraballo I. Investigation of the influence of particle size on the excipient percolation thresholds of HPMC hydrophilic matrices tablets. J. Pharm. Sci. 96 (2007) 2746-2756
27. Mirmehrabi M., Rohani S., Murthy K.S.K., and Radatus B. Solubility, dissolution rate and phase transition studies of ranitidine hydrochloride tautomeric forms. Int. J. Pharm. 282 (2004) 73-85
28. Peppas N.A., and Sahlin J.J. A simple equation for the description of solute release. 3. Coupling of diffusion and relaxation. Int. J. Pharm. 57 (1989) 169-172
29. Pham A.T., and Lee P.I. Probing the mechanism of drug release from hydroxypropylmethyl cellulose matrices. Pharm. Res. 11 (1994) 1379-1384
30. Ranga Roa K.V., Padmalatha Devi K., and Buri P. Cellulose matrices for zero-order release of soluble drugs. Drug Dev. Ind. Pharm. 14 (1988) 15-17
31. Ritger P.L., and Peppas N.A. A simple equation for description of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control Release 5 (1987) 23-26
32. Sia Heng P.W., Chan L.W., Easterbrook M.G., and Li X. Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets. J. Control Release 76 (2001) 39-49
33. Stauffer D., and Aharony A. Introduction to Percolation Theory. 2nd ed. (1992), Francis, London/Washington, DC
34. Velasco M.V., Ford J.L., Rowe P., and Rajabi-Siahboomi A.R. Influence of drug: hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from HPMC tablets. J. Control Release 57 (1999) 75-85
35. Yang L., and Fassihi R. Examination of drug solubility, polymer types, hydrodynamics and loading dose on drug release behavior from a trople-layer asymmetric configuration delivery system. Int. J. Pharm. 155 (1997) 219-229
36. Zuleger S., and Lippold B.C. Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism. Int. J. Pharm. 217 (2001) 139-152