Solubility, dissolution rate and phase transition studies of ranitidine hydrochloride tautomeric forms

International Journal of Pharmaceutics

Volumn 282, Issue 1-2, 2004, Pages 73-85

  Mirmehrabi, M ^a   Rohani, S ^a   Murthy, K S K ^b   Radatus, B ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b Brantford Chemicals Inc   (Canada)

Author keywords

Polymorphic transformation; Ranitidine hydrochloride; Solubility measurement and prediction; UNIQUAC

Indexed keywords

RANITIDINE;

ARTICLE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; INFRARED SPECTROSCOPY; PHASE TRANSITION; PRIORITY JOURNAL; SOLID STATE;

ANTI-ULCER AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; DRUG COMPOUNDING; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; ISOMERISM; KINETICS; MICROSCOPY, ELECTRON, SCANNING; RANITIDINE; SOFTWARE; SOLUBILITY; SOLUTIONS; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS; ULTRASONICS;

EID: 4444250224     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.05.031     Document Type: Article

References (24)

1. Abrams D.S., Prausnitz J.M. Statistical thermodynamics of liquid mixtures. A new expression for the excess Gibs energy of partly and completely miscible systems. AIChE J. 21:1975;116-128
2. Agatonovic-Kustrin S., Wu V., Rades T., Saville D., Tucker I.G. Ranitidine hydrochloride X-ray assay using a neural network. J. Pharm. Biomed. Anal. 22:2000;985-992
3. Bondi, A., 1968. Physical Properties of Molecular Crystals, Liquids and Gasses. Wiley, New York.
4. Canadian Pharmacists Association, 2000. Ranitidine HCl. Webcom Limited, Toronto, pp. 1772-1774.
5. Chiavone F.O., Rasmussen P. Modeling of salt solubilities in mixed solvents. Braz. J. Chem. Eng. 17:2000;117-131
6. Cholerton, T.J., Hunt, J.H., Klinkert, G., Smith, M.M., 1984. Spectroscopic studies on ranitidine - its structure and the influence of temperature and pH, J. Chem. Soc. Perkin Trans. II, 1761-1766.
7. Crookes D.J., 1987. Process for Forming Form 2 Ranitidine Hydrochloride. US Patent 4 672 133.
8. Forster, A., Gordon, K., Schmierer, D., Soper, N., Wu, V., Rades, T., 1998. Characterization of two polymorphic forms of ranitidine-HCl. Int. J. Vib. Spec. 2, Section 2.
9. Fredenslund A., Jones R.L., Prausnitz J.M. Group-contribution estimation of activity coefficient in nonideal liquid mixtures. AIChE J. 21:1975;1086-1099
10. Grant, D.W.J., Higuchi, T., 1990. Solubility Behavior of Organic Compounds, Techniques in Chemistry. Wiley, Toronto.
11. Hansen, H.K., Rasmussen, P., Fredenslund, A., Schiller, M., Gmehling, J., 1991. Vapor-Liquid Equilibria by UNIFAC Group Contribution. 5. Revision and Extension. I & EC Res. 30, 2352-2355.
12. Khanna, J.M., Kumar, N., Khera, B., Khanna, M., 1997. Process for the Manufacture of Form 1 Ranitidine Hydrochloride. US Patent 5 621 120.
13. Mirmehrabi, M., Rohani, S., 2004. Measurement and prediction of the solubility of stearic acid polymorphs by the UNIQUAC equation. Can. J. Chem. Eng., in press.
14. Mirmehrabi M., Rohani S., Murthy K.S.K., Radatus B. Characterization of tautomeric forms of ranitidine hydrochloride: thermal analysis, solid-state NMR, X-ray. J. Crystal Growth. 260:2004a;517-526
15. Mirmehrabi M., Rohani S., Murthy K.S.K., Radatus B. Improving the filterability and solid density of ranitidine hydrochloride Form 1. J. Pharm. Sci. 93:2004b;1692-1700
16. Murthy, K., Radatus, B.K., Sidhu, K.P.S., 1995. Reissued 2002. Process for Production of an Improved Form of Form 1 Ranitidine Hydrochloride having Improved Filtration and Drying Characteristics, Canadian Patent 2 120 874.
17. Ngooi, T.K., Antczak, C., Tindall, J.L.A., McGolrick, J.D., 1998. Preparation of Form 1 Ranitidine Hydrochloride. Canadian Patent 2 099 530.
18. Pinhoa S.P., Macedob E.A. Experimental measurement and modelling of KBr solubility in water, methanol, ethanol, and its binary mixed solvents at different temperatures. J. Chem. Therm. 34:2002;334-360
19. Prausnitz, J.M., Lichtenthaler, R.N., Azevedo, E.G., 1999. Molecular thermodynamics of Fluid-Phase Equilibria, third ed. Prentice-Hall, Upper Saddle River, NJ.
20. Price, B.J., Clitherow, J.W., Bradshaw, J., 1978. Aminoalkyl Furan Derivatives. US Patent 4 128 658.
21. Radatus, B., Murthy, K.S.K., 1997. Unpublished work. Brantford Chemicals Inc.
22. Schickaneder, H., Nikolopoulos, A., 1997. Process for Preparing Form 1 Ranitidine Hydrochloride. US Patent 5 663 381.
23. Sertsou, G., Agatonovic-Kustrin, S., Rades, T., 1999. The Use of DRIFTS to analyse binary mixtures of two polymorphic forms of ranitidine-HCl using only one specific peak. Int. J. Vib. Spec. 5, Section 3.
24. Yaws, C.L., Wang X.M., Satyro, M.A., 1999. Solubility parameters, liquid volume, and Van Der Waals volume and area, in: Yaws C.L. (Eds.), Chemical Properties Handbook: Physical, Thermodynamic, Environmental, Transport, Safety, and Health Related Properties for Organic and Inorganic Chemicals, McGraw Hill, New York, pp. 340-363.