In vitro and in vivo studies on chitosan beads of losartan duolite AP143 complex, optimized by using statistical experimental design

AAPS PharmSciTech

Volumn 10, Issue 3, 2009, Pages 743-751

  Madgulkar, Ashwini ^a   Bhalekar, Mangesh ^a   Swami, Megha ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

Chitosan TPP beads; Duolite AP143; Losartan potassium; Optimization; Pharmacodynamic studies; Sustained release

Indexed keywords

CHITOSAN; COLESTYRAMINE; DUOLITE AP 143; LOSARTAN POTASSIUM; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PHARMACODYNAMICS; PROCESS OPTIMIZATION; RAT; SUSTAINED DRUG RELEASE;

ALGORITHMS; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD PRESSURE; CALORIMETRY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CROSS-LINKING REAGENTS; EXCIPIENTS; FEMALE; LOSARTAN; MALE; MICROSCOPY, ELECTRON, SCANNING; MODELS, STATISTICAL; PARTICLE SIZE; POLYPHOSPHATES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SOLUBILITY;

EID: 70449524423     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9254-x     Document Type: Article

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