1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression

Journal of Bone and Mineral Metabolism

Volumn 27, Issue 6, 2009, Pages 643-652

  Sakai, Sadaoki ^a,b   Takaishi, Hironari ^a   Matsuzaki, Kenichiro ^a   Kaneko, Hironori ^a   Furukawa, Mitsuru ^a   Miyauchi, Yoshiteru ^a   Shiraishi, Ayako ^b   Saito, Keiji ^b   Tanaka, Akio ^b   Taniguchi, Tadatsugu ^c   Suda, Toshio ^a   Miyamoto, Takeshi ^a   Toyama, Yoshiaki ^a  

^a KEIO UNIVERSITY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

1 ,25(OH) 2D3; IFN ; NFATc1; Osteoclastogenesis; Vitamin D

Indexed keywords

ANTIBODY; BETA INTERFERON; CALCITRIOL; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DISEASE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; UPREGULATION;

BONE AND BONES; BONE MARROW CELLS; CALCITRIOL; CALCIUM; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRANULOCYTES; HUMANS; INTERFERON-BETA; MODELS, BIOLOGICAL; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; RANK LIGAND;

EID: 70449522251     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-009-0084-4     Document Type: Article

References (30)

1. JC Gallagher BL Riggs J Eisman A Hamstra SB Arnaud HF DeLuca 1979 Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium J Clin Invest 64 729 736 10.1172/JCI109516 1:CAS:528:DyaE1MXlvFSrtrc%3D 468987
2. T Okazaki T Igarashi HM Kronenberg 1988 5′-Flanking region of the parathyroid hormone gene mediates negative regulation by 1, 25-(OH)2 vitamin D3 J Biol Chem 263 2203 2208 1:CAS:528:DyaL1cXhsVCmsL0%3D 2448306
3. MB Demay MS Kiernan HF DeLuca HM Kronenberg 1992 Sequences in the human parathyroid hormone gene that bind the 1, 25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1, 25-dihydroxyvitamin D3 Proc Natl Acad Sci USA 89 8097 8101 10.1073/pnas.89.17.8097 1:CAS:528:DyaK3sXhvVSn 1325645
4. A Shiraishi S Takeda T Masaki Y Higuchi Y Uchiyama N Kubodera K Sato K Ikeda T Nakamura T Matsumoto E Ogata 2000 Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen J Bone Miner Res 15 770 779 10.1359/jbmr.2000.15. 4.770 1:CAS:528:DC%2BD3cXisFWmt7w%3D 10780869
5. Y Uchiyama Y Higuchi S Takeda T Masaki A Shira-Ishi K Sato N Kubodera K Ikeda E Ogata 2002 ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis Bone (NY) 30 582 588 1:CAS:528:DC%2BD38XisV2ksLY%3D
6. S Sairanen M Kärkkäinen R Tähtelä K Laitinen P Mäkelä C Lamberg-Allardt MJ Välimäki 2000 Bone mass and markers of bone and calcium metabolism in postmenopausal women treated with 1, 25-dihydroxyvitamin D (calcitriol) for four years Calcif Tissue Int 67 122 127 10.1007/s00223001118 1:CAS:528:DC%2BD3cXmtFCjtrs%3D 10920216
7. BP Lukert LG Raisz 1990 Glucocorticoid-induced osteoporosis: pathogenesis and management Ann Intern Med 112 352 364 1:CAS:528:DyaK3cXktlCktrs%3D 2407167
8. E Slatopolsky C Weerts J Thielan R Horst H Harter KJ Martin 1984 Marked suppression of secondary hyperparathyroidism by intravenous administration of 1, 25-dihydroxy-cholecalciferol in uremic patients J Clin Invest 74 2136 2143 10.1172/JCI111639 1:STN:280:DyaL2M%2FotVGnsw%3D%3D 6549016
9. T Miyamoto T Suda 2003 Differentiation and function of osteoclasts Keio J Med 52 1 7 12713016
10. H Yasuda N Shima N Nakagawa K Yamaguchi M Kinosaki S Mochizuki A Tomoyasu K Yano M Goto A Murakami E Tsuda T Morinaga K Higashio N Udagawa N Takahashi T Suda 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Proc Natl Acad Sci USA 95 3597 3602 10.1073/pnas.95.7.3597 1:CAS:528:DyaK1cXitlKjsLY%3D 9520411 (Pubitemid 28173173)
11. YY Kong H Yoshida I Sarosi HL Tan E Timms C Capparelli S Morony AJ Oliveira-dos-Santos G Van A Itie W Khoo A Wakeham CR Dunstan DL Lacey TW Mak WJ Boyle JM Penninger 1999 OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature (Lond) 397 315 323 10.1038/16852 1:CAS:528:DyaK1MXhtVOqs7w%3D (Pubitemid 29061638)
12. WC Dougall M Glaccum K Charrier K Rohrbach K Brasel T De Smedt E Daro J Smith ME Tometsko CR Maliszewski A Armstrong V Shen S Bain D Cosman D Anderson PJ Morrissey JJ Peschon J Schuh 1999 RANK is essential for osteoclast and lymph node development Genes Dev 13 2412 2424 10.1101/gad.13.18.2412 1:CAS:528:DyaK1MXmsVCgtr4%3D 10500098 (Pubitemid 29453612)
13. A Naito S Azuma S Tanaka T Miyazaki S Takaki K Takatsu K Nakao K Nakamura M Katsuki T Yamamoto J Inoue 1999 Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice Genes Cells 4 353 362 10.1046/j.1365-2443.1999.00265.x 1:CAS:528:DyaK1MXltlekt7s%3D 10421844 (Pubitemid 29359450)
14. H Takayanagi S Kim T Koga H Nishina M Isshiki H Yoshida A Saiura M Isobe T Yokochi J Inoue EF Wagner TW Mak T Kodama T Taniguchi 2002 Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts Dev Cell 3 889 901 10.1016/S1534-5807(02)00369-6 1:CAS:528:DC%2BD38XpslClsL8%3D 12479813 (Pubitemid 35460788)
15. RS Johnson BM Spiegelman V Papaioannou 1992 Pleiotropic effects of a null mutation in the c-fos proto-oncogene Cell 71 577 586 10.1016/0092-8674(92) 90592-Z 1:CAS:528:DyaK3sXlslGjuw%3D%3D 1423615
16. K Matsuo DL Galson C Zhao L Peng C Laplace KZ Wang MA Bachler H Amano H Aburatani H Ishikawa EF Wagner 2004 Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos J Biol Chem 279 26475 26480 10.1074/jbc.M313973200 1:CAS:528:DC%2BD2cXkvVWgtr4%3D 15073183 (Pubitemid 38798801)
17. M Asagiri K Sato T Usami S Ochi H Nishina H Yoshida I Morita EF Wagner TW Mak E Serfling H Takayanagi 2005 Autoamplification of NFATc1 expression determines its essential role in bone homeostasis J Exp Med 202 1261 1269 10.1084/jem.20051150 1:CAS:528:DC%2BD2MXht1Sntr%2FE 16275763 (Pubitemid 41586956)
18. K Matsuo JM Owens M Tonko C Elliott TJ Chambers EF Wagner 2000 Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation Nat Genet 24 184 187 10.1038/72855 1:CAS:528:DC%2BD3cXhtFCgtr0%3D 10655067 (Pubitemid 30094722)
19. H Takayanagi S Kim K Matsuo H Suzuki T Suzuki K Sato T Yokochi H Oda K Nakamura N Ida EF Wagner T Taniguchi 2002 RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta Nature (Lond) 416 744 749 10.1038/416744a 1:CAS:528:DC%2BD38XjtVKksLo%3D (Pubitemid 34429151)
20. JF Aloia A Vaswani JK Yeh K Ellis S Yasumura SH Cohn 1988 Calcitriol in the treatment of postmenopausal osteoporosis Am J Med 84 401 408 10.1016/0002-9343(88)90259-8 1:STN:280:DyaL1c7mtFWjuw%3D%3D 3279769
21. H Takasu A Sugita Y Uchiyama N Katagiri M Okazaki E Ogata K Ikeda 2006 c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs J Clin Invest 116 528 535 10.1172/JCI24742 1:CAS:528:DC%2BD28Xht1SqsLw%3D 16424941 (Pubitemid 43228371)
22. K Iwamoto T Miyamoto Y Sawatani N Hosogane I Hamaguchi M Takami K Nomiyama K Takagi T Suda 2004 Ligand-independent dimer formation of receptor activator of nuclear factor kappa B (RANK) induces incomplete osteoclast formation Biochem Biophys Res Commun 325 229 234 10.1016/j.bbrc.2004.10.024 1:CAS:528:DC%2BD2cXpt1artbY%3D 15522223 (Pubitemid 39441183)
23. M Yagi T Miyamoto Y Sawatani K Iwamoto N Hosogane N Fujita K Morita K Ninomiya T Suzuki K Miyamoto Y Oike M Takeya Y Toyama T Suda 2005 DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells J Exp Med 202 345 351 10.1084/jem.20050645 1:CAS:528:DC%2BD2MXntFCjt70%3D 16061724 (Pubitemid 41126951)
24. K Morita T Miyamoto N Fujita Y Kubota K Ito K Takubo K Miyamoto K Ninomiya T Suzuki R Iwasaki M Yagi H Takaishi Y Toyama T Suda 2007 Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification J Exp Med 204 1613 1623 1:CAS:528:DC%2BD2sXnslylsrY%3D 17576777
25. T Matsumoto T Miki H Hagino T Sugimoto S Okamoto T Hirota Y Tanigawara Y Hayashi M Fukunaga M Shiraki T Nakamura 2005 A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial J Clin Endocrinol Metab 90 5031 5036 10.1210/jc.2004-2552 1:CAS:528:DC%2BD2MXhtVWkur7J 15972580 (Pubitemid 41262250)
26. N Takahashi T Kukita BR MacDonald A Bird GR Mundy LM McManus M Miller A Boyde SJ Jones GD Roodman 1989 Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures J Clin Invest 83 543 550 10.1172/JCI113916 1:STN:280:DyaL1M7gvFGluw%3D%3D 2783589
27. BK Park H Zhang Q Zeng J Dai ET Keller T Giordano K Gu V Shah L Pei RJ Zarbo L McCauley S Shi S Chen CY Wang 2007 NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF Nat Med 13 62 69 10.1038/nm1519 1:CAS:528:DC%2BD2sXhvFWjug%3D%3D 17159986 (Pubitemid 46067387)
28. T Miyamoto O Ohneda F Arai K Iwamoto S Okada K Takagi DM Anderson T Suda 2001 Bifurcation of osteoclasts and dendritic cells from common progenitors Blood 98 2544 2554 10.1182/blood.V98.8.2544 1:CAS:528:DC%2BD3MXnslCqsL4%3D 11588053
29. 3 1α-hydroxylase gene in patients with pseudovitamin D-deficiency rickets N Engl J Med 338 653 661 10.1056/ NEJM199803053381004 1:CAS:528:DyaK1cXhvVylu7w%3D 9486994 (Pubitemid 28108435)
30. N Koike F Ichikawa Y Nishii E Stumpf 1998 Sustained osteoblast nuclear receptor binding of converted 1α, 25-dihydroxyvitamin D3 after administration of 3H-1α-hydroxyvitamin D3: a combined receptor autoradiography and radioassay time course study with comparison to 3H-1α, 25-dihydroxyvitamin D3 Calcif Tissue Int 63 391 395 10.1007/s002239900546 1:CAS:528:DyaK1cXntV2ltrw%3D 9799823 (Pubitemid 28476328)