Neuropeptide signaling near and far: How localized and timed is the action of neuropeptides in brain circuits?

Invertebrate Neuroscience

Volumn 9, Issue 2, 2009, Pages 57-75

  Nässel, Dick R ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Cotransmission; Drosophila; Insects; Neuromodulation; Neuropeptide

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; NEUROHORMONE; NEUROPEPTIDE; NEUROTRANSMITTER; PEPTIDASE;

BRAIN FUNCTION; DROSOPHILA; DROSOPHILA MELANOGASTER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; INSECT; INTERNEURON; NEUROCHEMISTRY; NEUROMODULATION; NEUROPHYSIOLOGY; NEUROPIL; NEUROTRANSMISSION; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC TRANSMISSION;

ANIMALS; BRAIN; DROSOPHILA; DROSOPHILA PROTEINS; INSECT PROTEINS; INSECTS; NEURAL PATHWAYS; NEURONS; NEUROPEPTIDES; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 70449521171     PISSN: 13542516     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10158-009-0090-1     Document Type: Review

References (132)

1. ME Adams M O'Shea 1983 Peptide cotransmitter at a neuromuscular junction Science 221 286 289 1:CAS:528:DyaL3sXkvVGmsrs%3D 6134339
2. G Baggerman A Cerstiaens A De Loof L Schoofs 2002 Peptidomics of the larval Drosophila melanogaster central nervous system J Biol Chem 277 40368 40374 1:CAS:528:DC%2BD38XnvFynsLg%3D 12171930
3. G Baggerman K Boonen P Verleyen A De Loof L Schoofs 2005 Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry J Mass Spectrom 40 250 260 1:CAS:528:DC%2BD2MXitFyhurs%3D 15706625
4. RT Birse EC Johnson PH Taghert DR Nässel 2006 Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides J Neurobiol 66 33 46 1:CAS:528: DC%2BD28XltVarug%3D%3D 16193493
5. ND Bland P Robinson JE Thomas AD Shirras AJ Turner RE Isaac 2009 Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2 Peptides 30 571 574 1:CAS:528:DC%2BD1MXisFOnu7o%3D 19038301
6. PR Bowser SS Tobe 2005 Immunocytochemical analysis of putative allatostatin receptor (DAR-2) distribution in the CNS of larval Drosophila melanogaster Peptides 26 81 87 1:CAS:528:DC%2BD2MXjsVKl 15626507
7. V Brezina KR Weiss 1997 Analyzing the functional consequences of transmitter complexity Trends Neurosci 20 538 543 1:CAS:528:DyaK2sXnt1Cqs7s%3D 9364669
8. C Cao MR Brown 2001 Localization of an insulin-like peptide in brains of two flies Cell Tissue Res 304 317 321 1:CAS:528:DC%2BD3MXjtVGktbY%3D 11396725
9. Chan-Palay V, Palay SL (1984) Coexistence of neuroactive substances in neurons. Wiley, New York, NY
10. B Chen IA Meinertzhagen SR Shaw 1999 Circadian rhythms in light-evoked responses of the fly's compound eye, and the effects of neuromodulators 5-HT and the peptide PDF J Comp Physiol [A] 185 393 404 1:CAS:528:DC%2BD3cXhs1Sgug%3D%3D
11. MJ Coleman PH Konstant BS Rothman MP Nusbaum 1994 Neuropeptide degradation produces functional inactivation in the crustacean nervous system J Neurosci 14 6205 6216 1:CAS:528:DyaK2MXhtFyhsL4%3D 7931573
12. A Couto M Alenius BJ Dickson 2005 Molecular, anatomical, and functional organization of the Drosophila olfactory system Curr Biol 15 1535 1547 1:CAS:528:DC%2BD2MXpslyit7Y%3D 16139208
13. HA Dierick RJ Greenspan 2007 Serotonin and neuropeptide F have opposite modulatory effects on fly aggression Nat Genet 39 678 682 1:CAS:528: DC%2BD2sXksFersbo%3D 17450142
14. L Enell Y Hamasaka A Kolodziejczyk DR Nässel 2007 gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter J Comp Neurol 505 18 31 1:CAS:528: DC%2BD2sXht1yltL%2FK 17729251
15. PS Estes GL Ho R Narayanan M Ramaswami 2000 Synaptic localization and restricted diffusion of a Drosophila neuronal synaptobrevin-green fluorescent protein chimera in vivo J Neurogenet 13 233 255 1:STN:280:DC%2BD3czhs1KhtA%3D%3D 10858822
16. G Feng V Reale H Chatwin K Kennedy R Venard C Ericsson K Yu PD Evans LM Hall 2003 Functional characterization of a neuropeptide F-like receptor from Drosophila melanogaster Eur J Neurosci 18 227 238 12887405
17. E Fishilevich LB Vosshall 2005 Genetic and functional subdivision of the Drosophila antennal lobe Curr Biol 15 1548 1553 1:CAS:528:DC%2BD2MXpslyit7c%3D 16139209
18. RM Glantz CS Miller DR Nässel 2000 Tachykinin-related peptide and GABA-mediated presynaptic inhibition of crayfish photoreceptors J Neurosci 20 1780 1790 1:CAS:528:DC%2BD3cXhsVGmt7w%3D 10684879
19. Y Hamasaka DR Nässel 2006 Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila J Comp Neurol 494 314 330 1:CAS:528:DC%2BD28XltValtA%3D%3D 16320241
20. U Hanesch KF Fischbach M Heisenberg 1989 Neuronal architecture of the central complex in Drosophila melanogaster Cell Tissue Res 257 343 366
21. JB Harrison HH Chen AD Blake NS Huskisson P Barker DB Sattelle 1995 Localization in the nervous system of Drosophila melanogaster of a C-terminus anti-peptide antibody to a cloned Drosophila muscarinic acetylcholine receptor J Neuroendocrinol 7 347 352 1:CAS:528:DyaK2MXmvVKhtrw%3D 7550280
22. JB Harrison HH Chen E Sattelle PJ Barker NS Huskisson JJ Rauh D Bai DB Sattelle 1996 Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system in Drosophila melanogaster Cell Tissue Res 284 269 278 1:CAS:528:DyaK28Xjs1Sgur8%3D 8625394
23. F Hauser G Cazzamali M Williamson W Blenau CJ Grimmelikhuijzen 2006 A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera Prog Neurobiol 80 1 19 1:CAS:528: DC%2BD28XhtFKmu7nO 17070981
24. S Heinze U Homberg 2008 Neuroarchitecture of the central complex of the desert locust: Intrinsic and columnar neurons J Comp Neurol 511 454 478 18837039
25. C Helfrich-Förster U Homberg 1993 Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity J Comp Neurol 337 177 190 8276996
26. C Helfrich-Förster T Edwards K Yasuyama B Wisotzki S Schneuwly R Stanewsky IA Meinertzhagen A Hofbauer 2002 The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function J Neurosci 22 9255 9266 12417651
27. C Helfrich-Förster OT Shafer C Wülbeck E Grieshaber D Rieger P Taghert 2007 Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster J Comp Neurol 500 47 70 17099895
28. M Herkenham 1987 Mismatches between neurotransmitter and receptor localizations in brain: observations and implications Neuroscience 23 1 38 1:CAS:528:DyaL2sXmt12ht74%3D 2891080
29. RS Hewes PH Taghert 2001 Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome Genome Res 11 1126 1142 1:CAS:528: DC%2BD3MXkt12ru7g%3D 11381038
30. T Hökfelt D Millhorn K Seroogy Y Tsuruo S Ceccatelli B Lindh B Meister T Melander M Schalling T Bartfai 1987 Coexistence of peptides with classical neurotransmitters Experientia 43 768 780 2885215
31. U Homberg 2002 Neurotransmitters and neuropeptides in the brain of the locust Microsc Res Tech 56 189 209 1:CAS:528:DC%2BD38XitFKqu7c%3D 11810722
32. Homberg U, Müller U (1999) Neuroactive substances in the antennal lobe. In: Hansson BS (ed) Insect olfaction. Springer, Berlin, pp 181-206
33. FM Horodyski J Ewer LM Riddiford JW Truman 1993 Isolation, characterization and expression of the eclosion hormone gene of Drosophila melanogaster Eur J Biochem 215 221 228 1:CAS:528:DyaK3sXmtFyksL4%3D 8344291
34. S Hyun Y Lee ST Hong S Bang D Paik J Kang J Shin J Lee K Jeon S Hwang E Bae J Kim 2005 Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF Neuron 48 267 278 1:CAS:528:DC%2BD2MXhtF2iur7N 16242407
35. R Ignell CM Root RT Birse JW Wang DR Nässel ÅM Winther 2009 Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila Proc Natl Acad Sci U S A 106 13070 13075 1:CAS:528:DC%2BD1MXhtVKru7zM 19625621
36. RE Isaac DR Nässel 2003 Identification and localization of a neprilysin-like activity that degrades tachykinin-related peptides in the brain of the cockroach, Leucophaea maderae, and locust, Locusta migratoria J Comp Neurol 457 57 66 1:CAS:528:DC%2BD3sXhs1ymsr0%3D 12541324
37. R Isaac L Schoofs TA Williams D Veelaert M Sajid P Corvol D Coates 1998 A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide Biochem J 330 Pt 1 61 65 1:CAS:528:DyaK1cXhs1yqtLc%3D 9461491
38. RE Isaac RJ Siviter P Stancombe D Coates AD Shirras 2000 Conserved roles for peptidases in the processing of invertebrate neuropeptides Biochem Soc Trans 28 460 464 1:CAS:528:DC%2BD3cXmsVehsLg%3D 10961940
39. RE Isaac EC Johnson N Audsley AD Shirras 2007 Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila J Exp Biol 210 4465 4470 1:CAS:528:DC%2BD1cXhslOjsrs%3D 18055635
40. RE Isaac ND Bland AD Shirras 2009 Neuropeptidases and the metabolic inactivation of insect neuropeptides Gen Comp Endocrinol 162 8 17 1:CAS:528:DC%2BD1MXltFWitrk%3D 19135055
41. K Ito K Suzuki P Estes M Ramaswami D Yamamoto NJ Strausfeld 1998 The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen Learn Mem 5 52 77 1:STN:280:DyaK1Mzot1Wktw%3D%3D 10454372
42. LY Jan YN Jan 1982 Peptidergic transmission in sympathetic ganglia of the frog J Physiol 327 219 246 1:CAS:528:DyaL38XktlersLo%3D 6181250
43. YN Jan LY Jan 1983 Coexistence and corelease of cholinergic and peptidergic transmitters in frog sympathetic ganglia Fed Proc 42 2929 2933 1:CAS:528:DyaL3sXlsFahs7Y%3D 6136426
44. YN Jan LY Jan 1983 Some features of peptidergic transmission Prog Brain Res 58 49 59 1:CAS:528:DyaL3sXltlektrw%3D 6138814
45. HA Johard JE Muren R Nichols DS Larhammar DR Nässel 2001 A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein Brain Res 919 94 105 1:CAS:528:DC%2BD3MXnvFCksbk%3D 11689166
46. HA Johard LE Enell E Gustafsson P Trifilieff JA Veenstra DR Nässel 2008 Intrinsic neurons of Drosophila mushroom bodies express short neuropeptide F: relations to extrinsic neurons expressing different neurotransmitters J Comp Neurol 507 1479 1496 1:CAS:528:DC%2BD1cXktlaitbc%3D 18205208
47. HA Johard T Yoishii H Dircksen P Cusumano F Rouyer C Helfrich- Förster DR Nässel 2009 Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons J Comp Neurol 516 59 73 1:CAS:528:DC%2BD1MXhtVSntbbO 19565664
48. Johnson EC (2006) Post-genomic approaches to resolve neuropeptide signaling in Drosophila. In: Satake H (ed) Invertebrate neuropeptides and hormones: basic knowledge and recent advances. Transworld Research Network, Trivandrum, pp 1-46
49. EC Johnson SF Garczynski D Park JW Crim DR Nässel PH Taghert 2003 Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophila melanogaster Proc Natl Acad Sci U S A 100 6198 6203 1:CAS:528:DC%2BD3sXjvFOlurc%3D 12730362
50. EC Johnson OT Shafer JS Trigg J Park DA Schooley JA Dow PH Taghert 2005 A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling J Exp Biol 208 1239 1246 1:CAS:528:DC%2BD2MXktlegtL4%3D 15781884
51. PE Jonas B Phannavong R Schuster C Schroder ED Gundelfinger 1994 Expression of the ligand-binding nicotinic acetylcholine receptor subunit D alpha 2 in the Drosophila central nervous system J Neurobiol 25 1494 1508 1:CAS:528:DyaK2MXis1CrtLw%3D 7861114
52. T Karhunen FS Vilim V Alexeeva KR Weiss PJ Church 2001 Targeting of peptidergic vesicles in cotransmitting terminals J Neurosci 21 RC127 1:STN:280:DC%2BD3M3msFemsA%3D%3D 11157098
53. YJ Kim D Zitnan CG Galizia KH Cho ME Adams 2006 A command chemical triggers an innate behavior by sequential activation of multiple peptidergic ensembles Curr Biol 16 1395 1407 1:CAS:528:DC%2BD28XntlCrt74%3D 16860738
54. A Kolodziejczyk X Sun IA Meinertzhagen DR Nässel 2008 Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system PLoS ONE 3 e2110 18464935
55. BC Lear L Zhang R Allada 2009 The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior PLoS Biol 7 e1000154 19621061
56. G Lee JH Park 2004 Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster Genetics 167 311 323 1:CAS:528:DC%2BD2cXlsFOitrk%3D 15166157
57. W Li Y Pan Z Wang H Gong Z Gong L Liu 2009 Morphological characterization of single fan-shaped body neurons in Drosophila melanogaster Cell Tissue Res 336 509 519 19357870
58. SQ Lima G Miesenbock 2005 Remote control of behavior through genetically targeted photostimulation of neurons Cell 121 141 152 1:CAS:528: DC%2BD2MXjsVaksLo%3D 15820685
59. M Ludwig G Leng 2006 Dendritic peptide release and peptide-dependent behaviours Nat Rev Neurosci 7 126 136 1:CAS:528:DC%2BD28XlvV2qtQ%3D%3D 16429122
60. L Luo EM Callaway K Svoboda 2008 Genetic dissection of neural circuits Neuron 57 634 660 1:CAS:528:DC%2BD1cXjslegt70%3D 18341986
61. A Lysakowski H Figueras SD Price YY Peng 1999 Dense-cored vesicles, smooth endoplasmic reticulum, and mitochondria are closely associated with non-specialized parts of plasma membrane of nerve terminals: implications for exocytosis and calcium buffering by intraterminal organelles J Comp Neurol 403 378 390 1:STN:280:DyaK1M7gtFWhug%3D%3D 9886037
62. E Marder D Bucher 2007 Understanding circuit dynamics using the stomatogastric nervous system of lobsters and crabs Annu Rev Physiol 69 291 316 1:CAS:528:DC%2BD2sXltVaks7Y%3D 17009928
63. SL McNabb JD Baker J Agapite H Steller LM Riddiford JW Truman 1997 Disruption of a behavioral sequence by targeted death of peptidergic neurons in Drosophila Neuron 19 813 823 1:CAS:528:DyaK2sXntFersL0%3D 9354328
64. IA Meinertzhagen E Pyza 1999 Neurotransmitter regulation of circadian structural changes in the fly's visual system Microsc Res Tech 45 96 105 1:CAS:528:DyaK1MXjsFyjsrc%3D 10332727
65. A Merighi 2002 Costorage and coexistence of neuropeptides in the mammalian CNS Prog Neurobiol 66 161 190 1:CAS:528:DC%2BD38Xis1egtLs%3D 11943450
66. I Mertens A Vandingenen EC Johnson OT Shafer W Li JS Trigg A De Loof L Schoofs PH Taghert 2005 PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors Neuron 48 213 219 1:CAS:528: DC%2BD2MXhtF2itbfK 16242402
67. DR Nässel 1988 Serotonin and serotonin-immunoreactive neurons in the nervous system of insects Prog Neurobiol 30 1 85 3275407
68. DR Nässel 1991 Neurotransmitters and neuromodulators in the insect visual system Prog Neurobiol 37 179 254 1682973
69. DR Nässel 1993 Neuropeptides in the insect brain: a review Cell Tissue Res 273 1 29 8364953
70. DR Nässel 2002 Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones Prog Neurobiol 68 1 84 12427481
71. DR Nässel U Homberg 2006 Neuropeptides in interneurons of the insect brain Cell Tissue Res 326 1 24 16761145
72. DR Nässel S Shiga CJ Mohrherr KR Rao 1993 Pigment-dispersing hormone-like peptide in the nervous system of the flies Phormia and Drosophila: immunocytochemistry and partial characterization J Comp Neurol 331 183 198 8509499
73. DR Nässel R Mentlein T Bollner A Karlsson 2000 Proline-specific dipeptidyl peptidase activity in the cockroach brain and intestine: partial characterization, distribution, and inactivation of tachykinin-related peptides J Comp Neurol 418 81 92 10701757
74. DR Nässel LE Enell JG Santos C Wegener HA Johard 2008 A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions BMC Neurosci 9 90 18803813
75. MN Nitabach PH Taghert 2008 Organization of the Drosophila circadian control circuit Curr Biol 18 R84 R93 1:CAS:528:DC%2BD1cXot1Gruw%3D%3D 18211849
76. MP Nusbaum 2002 Regulating peptidergic modulation of rhythmically active neural circuits Brain Behav Evol 60 378 387 12563170
77. MP Nusbaum DM Blitz AM Swensen D Wood E Marder 2001 The roles of co-transmission in neural network modulation Trends Neurosci 24 146 154 1:CAS:528:DC%2BD3MXht12isrc%3D 11182454
78. M O'Shea CA Bishop 1982 Neuropeptide proctolin associated with an identified skeletal motoneuron J Neurosci 2 1242 1251 6126529
79. 2+ action on neuropeptide and acetylcholine release in Aplysia californica J Physiol 535 647 662 1:CAS:528:DC%2BD3MXnsVektbc%3D 11559764
80. LA Oland JP Biebelhausen LP Tolbert 2008 Glial investment of the adult and developing antennal lobe of Drosophila J Comp Neurol 509 526 550 18537134
81. SR Olsen RI Wilson 2008 Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila Trends Neurosci 31 512 520 1:CAS:528:DC%2BD1cXhtFCrsr3N 18775572
82. JH Park C Helfrich-Förster G Lee L Liu M Rosbash JC Hall 2000 Differential regulation of circadian pacemaker output by separate clock genes in Drosophila Proc Natl Acad Sci USA 97 3608 3613 1:CAS:528:DC%2BD3cXitlWquro%3D 10725392
83. D Park JA Veenstra JH Park PH Taghert 2008 Mapping peptidergic cells in Drosophila: where DIMM fits in PLoS ONE 3 e1896 18365028
84. W Pereanu V Hartenstein 2006 Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage J Neurosci 26 5534 5553 1:CAS:528: DC%2BD28XlsVOhtrg%3D 16707805
85. BD Pfeiffer A Jenett AS Hammonds TT Ngo S Misra C Murphy A Scully JW Carlson KH Wan TR Laverty C Mungall R Svirskas JT Kadonaga CQ Doe MB Eisen SE Celniker GM Rubin 2008 Tools for neuroanatomy and neurogenetics in Drosophila Proc Natl Acad Sci U S A 105 9715 9720 1:CAS:528:DC%2BD1cXovVKnsb0%3D 18621688
86. J Poels RT Birse RJ Nachman J Fichna A Janecka J Vanden Broeck DR Nässel 2009 Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6 Peptides 30 545 556 1:CAS:528: DC%2BD1MXisFOnu78%3D 19022310
87. R Predel C Wegener WK Russell SE Tichy DH Russell RJ Nachman 2004 Peptidomics of CNS-associated neurohemal systems of adult Drosophila melanogaster: a mass spectrometric survey of peptides from individual flies J Comp Neurol 474 379 392 1:CAS:528:DC%2BD2cXlsFCmsLo%3D 15174081
88. E Pyza IA Meinertzhagen 1996 Neurotransmitters regulate rhythmic size changes amongst cells in the fly's optic lobe J Comp Physiol [A] 178 33 45 1:CAS:528:DyaK2sXjt1Kksbk%3D (Pubitemid 3017432)
89. JC Radford SA Davies JA Dow 2002 Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles J Biol Chem 277 38810 38817 1:CAS:528:DC%2BD38Xns1Cntb0%3D 12163486
90. CM Root K Masuyama DS Green LE Enell DR Nässel CH Lee JW Wang 2008 A presynaptic gain control mechanism fine-tunes olfactory behavior Neuron 59 311 321 1:CAS:528:DC%2BD1cXpsFOgt7s%3D 18667158
91. EJ Rulifson SK Kim R Nusse 2002 Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes Science 296 1118 1120 1:CAS:528: DC%2BD38XjslamsLo%3D 12004130
92. C Salio L Lossi F Ferrini A Merighi 2006 Neuropeptides as synaptic transmitters Cell Tissue Res 326 583 598 1:CAS:528:DC%2BD28XpvFalt78%3D 16847638
93. N Sanchez-Soriano W Bottenberg A Fiala U Haessler A Kerassoviti E Knust R Lohr A Prokop 2005 Are dendrites in Drosophila homologous to vertebrate dendrites? Dev Biol 288 126 138 1:CAS:528:DC%2BD2MXht1Oltb7N 16223476
94. JG Santos M Vomel R Struck U Homberg DR Nässel C Wegener 2007 Neuroarchitecture of peptidergic systems in the larval ventral ganglion of Drosophila melanogaster PLoS ONE 2 e695 17668072
95. J Schachtner B Trosowski W D'Hanis S Stubner U Homberg 2004 Development and steroid regulation of RFamide immunoreactivity in antennal-lobe neurons of the sphinx moth Manduca sexta J Exp Biol 207 2389 2400 1:CAS:528: DC%2BD2cXmvVeisL0%3D 15184511
96. L Schoofs D Veelaert A De Loof R Huybrechts E Isaac 1998 Immunocytochemical distribution of angiotensin I-converting enzyme-like immunoreactivity in the brain and testis of insects Brain Res 785 215 227 1:CAS:528:DyaK1cXhvVSjt7Y%3D 9518620
97. R Schuster B Phannavong C Schroder ED Gundelfinger 1993 Immunohistochemical localization of a ligand-binding and a structural subunit of nicotinic acetylcholine receptors in the central nervous system of Drosophila melanogaster J Comp Neurol 335 149 162 1:CAS:528:DyaK2cXhtVanu7g%3D 8227511
98. JL Semmelhack JW Wang 2009 Select Drosophila glomeruli mediate innate olfactory attraction and aversion Nature 459 218 223 1:CAS:528: DC%2BD1MXltValtL4%3D 19396157
99. OT Shafer C Helfrich-Förster SC Renn PH Taghert 2006 Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes J Comp Neurol 498 180 193 16856134
100. OT Shafer DJ Kim R Dunbar-Yaffe VO Nikolaev MJ Lohse PH Taghert 2008 Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging Neuron 58 223 237 1:CAS:528:DC%2BD1cXlsVSks70%3D 18439407
101. I Sinakevitch SM Farris NJ Strausfeld 2001 Taurine-, aspartate- and glutamate-like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body J Comp Neurol 439 352 367 1:STN:280:DC%2BD3MrkvFSjtQ%3D%3D 11596059
102. I Sinakevitch M Sjöholm BS Hansson NJ Strausfeld 2008 Global and local modulatory supply to the mushroom bodies of the moth Spodoptera littoralis Arthropod Struct Dev 37 260 272 18406668
103. M Sjöholm I Sinakevitch NJ Strausfeld R Ignell BS Hansson 2006 Functional division of intrinsic neurons in the mushroom bodies of male Spodoptera littoralis revealed by antibodies against aspartate, taurine, FMRF-amide, Mas-allatotropin and DC0 Arthropod Struct Dev 35 153 168 18089067
104. NJ Skaer DR Nassel SH Maddrell NJ Tublitz 2002 Neurochemical fine tuning of a peripheral tissue: peptidergic and aminergic regulation of fluid secretion by Malpighian tubules in the tobacco hawkmoth M. sexta J Exp Biol 205 1869 1880 1:CAS:528:DC%2BD38Xmt1Gqsrk%3D 12077163
105. W Stein ND DeLong DE Wood MP Nusbaum 2007 Divergent co-transmitter actions underlie motor pattern activation by a modulatory projection neuron Eur J Neurosci 26 1148 1165 17767494
106. Strausfeld NJ (1976) Atlas of an insect brain. Springer, Berlin, Heidelberg
107. NJ Strausfeld I Sinakevitch I Vilinsky 2003 The mushroom bodies of Drosophila melanogaster: an immunocytological and golgi study of Kenyon cell organization in the calyces and lobes Microsc Res Tech 62 151 169 12966500
108. G Szapiro B Barbour 2009 Parasynaptic signalling by fast neurotransmitters: the cerebellar cortex Neuroscience 162 644 655 1:CAS:528:DC%2BD1MXptVantbc%3D 19358875
109. NK Tanaka H Tanimoto K Ito 2008 Neuronal assemblies of the Drosophila mushroom body J Comp Neurol 508 711 755 18395827
110. CA Taylor ÅM Winther RJ Siviter AD Shirras RE Isaac DR Nässel 2004 Identification of a proctolin preprohormone gene (Proct) of Drosophila melanogaster: expression and predicted prohormone processing J Neurobiol 58 379 391 1:CAS:528:DC%2BD2cXitFWis7s%3D 14750150
111. S Terhzaz P Rosay SF Goodwin JA Veenstra 2007 The neuropeptide SIFamide modulates sexual behavior in Drosophila Biochem Biophys Res Commun 352 305 310 1:CAS:528:DC%2BD28XhtlShsr7J 17126293
112. S Utz W Huetteroth C Wegener J Kahnt R Predel J Schachtner 2007 Direct peptide profiling of lateral cell groups of the antennal lobes of Manduca sexta reveals specific composition and changes in neuropeptide expression during development Dev Neurobiol 67 764 777 1:CAS:528:DC%2BD2sXmt1Sqsro%3D 17443823
113. J Vanden Broeck 2001 Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster Peptides 22 241 254
114. P Verleyen J Huybrechts G Baggerman A Van Lommel A De Loof L Schoofs 2004 SIFamide is a highly conserved neuropeptide: a comparative study in different insect species Biochem Biophys Res Commun 320 334 341 1:CAS:528: DC%2BD2cXlt1egsb0%3D 15219831
115. FS Vilim EC Cropper DA Price I Kupfermann KR Weiss 1996 Release of peptide cotransmitters in Aplysia: regulation and functional implications J Neurosci 16 8105 8114 1:CAS:528:DyaK28Xns1Siuro%3D 8987835
116. FS Vilim DA Price W Lesser I Kupfermann KR Weiss 1996 Costorage and corelease of modulatory peptide cotransmitters with partially antagonistic actions on the accessory radula closer muscle of Aplysia californica J Neurosci 16 8092 8104 1:CAS:528:DyaK28Xns1Sitbw%3D 8987834
117. LB Vosshall RF Stocker 2007 Molecular architecture of smell and taste in Drosophila Annu Rev Neurosci 30 505 533 1:CAS:528:DC%2BD2sXptFKnu78%3D 17506643
118. J Wang X Ma JS Yang X Zheng CT Zugates CH Lee T Lee 2004 Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis Neuron 43 663 672 1:CAS:528:DC%2BD2cXns1yms7w%3D 15339648
119. C Wegener A Gorbashov 2008 Molecular evolution of neuropeptides in the genus Drosophila Genome Biol 9 R131 18717992
120. C Wegener T Reinl L Jänsch R Predel 2006 Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma-specific peptide expression and differential processing J Neurochem 96 1362 1374 1:CAS:528:DC%2BD28XivFSrurk%3D 16441518
121. T Wen CA Parrish D Xu Q Wu P Shen 2005 Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity Proc Natl Acad Sci U S A 102 2141 2146 1:CAS:528: DC%2BD2MXhvFGqs7w%3D 15677721
122. D Wicher HJ Agricola S Sohler M Gundel SH Heinemann L Wollweber M Stengl C Derst 2006 Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion J Neurophysiol 95 2314 2325 1:CAS:528:DC%2BD28XjslOisbo%3D 16319199
123. ÅM Winther RJ Siviter RE Isaac R Predel DR Nässel 2003 Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila J Comp Neurol 464 180 196 1:CAS:528:DC%2BD3sXntV2ltLg%3D 12898611
124. ÅM Winther A Acebes A Ferrus 2006 Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila Mol Cell Neurosci 31 399 406 1:CAS:528:DC%2BD28Xit1Cmt7s%3D 16289899
125. DE Wood MP Nusbaum 2002 Extracellular peptidase activity tunes motor pattern modulation J Neurosci 22 4185 4195 1:CAS:528:DC%2BD38XjvVartbk%3D 12019336
126. Q Wu T Wen G Lee JH Park HN Cai P Shen 2003 Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system Neuron 39 147 161 1:CAS:528:DC%2BD3sXlsV2rsr0%3D 12848939
127. Q Wu Z Zhao P Shen 2005 Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems Nat Neurosci 8 1350 1355 1:CAS:528:DC%2BD2MXhtVeqs7%2FF 16172603
128. N Yapici YJ Kim C Ribeiro BJ Dickson 2008 A receptor that mediates the post-mating switch in Drosophila reproductive behaviour Nature 451 33 37 18066048
129. JY Yew Y Wang N Barteneva S Dikler KK Kutz-Naber L Li EA Kravitz 2009 Analysis of neuropeptide expression and localization in adult Drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry J Proteome Res 8 1271 1284 1:CAS:528:DC%2BD1MXht1Oiu7Y%3D 19199706
130. JG Yoon B Stay 1995 Immunocytochemical localization of Diploptera punctata allatostatin-like peptide in Drosophila melanogaster J Comp Neurol 363 475 488 1:CAS:528:DyaK28XlslamsQ%3D%3D 8847412
131. YQ Zhang CK Rodesch K Broadie 2002 Living synaptic vesicle marker: synaptotagmin-GFP Genesis 34 142 145 1:CAS:528:DC%2BD38XosFKnur0%3D 12324970
132. GK Zupanc 1996 Peptidergic transmission: from morphological correlates to functional implications Micron 27 35 91 1:CAS:528:DyaK28Xlt1ejt7k%3D 8756315