Extracellular Peptidase Activity Tunes Motor Pattern Modulation

Journal of Neuroscience

Volumn 22, Issue 10, 2002, Pages 4185-4195

  Wood, Debra E ^a,b   Nusbaum, Michael P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aminopeptidase; Cotransmission; Crustacea; Motor pattern generation; Neuromodulation; Neuropeptides; Peptidase inhibitor; Proctolin; Stomatogastric nervous system; Tachykinin

Indexed keywords

4 AMINOBUTYRIC ACID; AMINOPEPTIDASE; NEUROPEPTIDE; NEUROTRANSMITTER; PEPTIDASE; PROCTOLIN; TACHYKININ; AMASTATIN; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; OLIGOPEPTIDE; PEPTIDE; PROTEINASE INHIBITOR; SPANTIDE; SUBSTANCE P;

ABDOMINAL GANGLION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRAB; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR SPACE; MALE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOTOR ACTIVITY; MOTOR CONTROL; NERVE CELL; NERVE CELL STIMULATION; NERVE PROJECTION; NEUROMODULATION; NEUROPIL; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TRANSPORT; RECEPTOR BINDING; ANIMAL; BRACHYURA; DIFFUSION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GANGLION; IN VITRO STUDY; METABOLISM; MOTONEURON; NERVOUS SYSTEM; PERIODICITY; PHYSIOLOGY; SECRETION;

AMINOPEPTIDASES; ANIMALS; ANTI-BACTERIAL AGENTS; BRACHYURA; DIFFUSION; EXTRACELLULAR SPACE; GANGLIA, INVERTEBRATE; MALE; MOTOR NEURONS; NERVOUS SYSTEM; NEUROPEPTIDES; OLIGOPEPTIDES; PEPTIDES; PERIODICITY; PROTEASE INHIBITORS; SUBSTANCE P; TACHYKININS;

EID: 0037095664     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-10-04185.2002     Document Type: Article

References (39)

1. Agnati LF, Zoli M, Stromberg I, Fuxe K (1995) Intercellular communication in the brain: wiring versus volume transmission. Neuroscience 69:711-726.
2. Bartos M, Nusbaum MP (1997) Intercircuit control of motor pattern modulation by presynaptic inhibition. J Neurosci 17:2247-2256.
3. Bartos M, Manor Y, Nadim F, Marder E, Nusbaum MP (1999) Coordination of fast and slow rhythmic neuronal circuits. J Neurosci 19:6650-6660.
4. Blitz DM, Nusbaum MP (1997) Motor pattern selection via inhibition of parallel pathways. J Neurosci 17:4965-4975.
5. Blitz DM, Christie AE, Coleman MJ, Norris BJ, Marder E, Nusbaum MP (1999) Different proctolin neurons elicit distinct motor patterns from a multifunctional neuronal network. J Neurosci 19:5449-5463.
6. 1-receptor-mediated suppression of excitatory transmission in the rat parabrachial nucleus. J Neurophysiol 82:1689-1696.
7. Christie AE, Lundquist CT, Nässel DR, Nusbaum MP (1997) Two novel tachykinin-related peptides from the nervous system of the crab Cancer borealis. J Exp Biol 200:2279-2294.
8. Coleman MJ, Nusbaum MP (1994) Functional consequences of compartmentalization of synaptic input. J Neurosci 14:6544-6552.
9. Coleman MJ, Konstant PH, Rothman BS, Nusbaum MP (1994) Neuropeptide degradation produces functional inactivation in the crustacean nervous system. J Neurosci 14:6205-6216.
10. Coleman MJ, Meyrand P, Nusbaum MP (1995) A switch between two modes of synaptic transmission mediated by presynaptic inhibition. Nature 378:502-505.
11. Duggan AW, Schaible HG, Hope PJ, Lang CW (1992) Effect of peptidase inhibition on the pattern of intraspinally released immunoreactive substance P detected with antibody microprobes. Brain Res 579:261-269.
12. 2+. J Neurosci 12:810-817.
13. Harris-Warrick RM, Marder E, Selverston A, Moulins M (1992) Dynamic biological networks: the stomatogastric nervous system. Cambridge, MA: MIT.
14. Hooper SL, Marder E (1987) Modulation of the lobster pyloric rhythm by the peptide proctolin. J Neurosci 7:2097-2112.
15. Hurwitz I, Perrins R, Xin Y, Weiss KR, Kupfermann I (1999) C-PR neuron of Aplysia has differential effects on "feeding" cerebral interneurons, including myomodulin-positive CBI-12. J Neurophysiol 81:521-534.
16. Jan LY, Jan YN (1982) Peptidergic transmission in sympathetic ganglia of the frog. J Physiol (Lond) 327:219-246.
17. Karhunen T, Vilim FS, Alexeeva V, Weiss KR, Church PJ (2001) Targeting of peptidergic vesicles in cotransmitting terminals. J Neurosci 21:RC127(1-5).
18. Kombian SB, Mouginot D, Pittman Q (1997) Dendritically released peptides act as retrograde modulators of afferent excitation in the supraoptic nucleus in vitro. Neuron 19:903-912.
19. Marder E, Hooper SL, Siwicki KK (1986) Modulatory action and distribution of the neuropeptide proctolin in the crustacean stomatogastric nervous system. J Comp Neurol 243:454-467.
20. McKelvy J, Blumberg S (1986) Inactivation and metabolism of neuropeptides. Annu Rev Neurosci 9:211-248.
21. Norris BJ, Coleman MJ, Nusbaum MP (1996) Pyloric motor pattern modification by a newly identified projection neuron in the crab stomatogastric nervous system. J Neurophysiol 75:97-108.
22. Nusbaum MP, Marder E (1989a) A modulatory proctolin-containing neuron (MPN). I. Identification and characterization. J Neurosci 9:1591-1599.
23. Nusbaum MP, Marder E (1989b) A modulatory proctolin-containing neuron (MPN). II. State-dependent modulation of rhythmic motor activity. J Neurosci 9:1600-1607.
24. Nusbaum MP, Wood DE (1999) The role of cotransmitters and peptidase activity in shaping the actions of peptidergic neurons. Soc Neurosci Abstr 25:1967.
25. Nusbaum MP, Blitz DM, Swensen AM, Wood D, Marder E (2001) The roles of co-transmission in neural network modulation. Trends Neurosci 24:146-154.
26. Owens DF, Menon JG, Rothman BS (1992) Structure-activity relationship of the neurotransmitter alpha-bag cell peptide on Aplysia LUQ neurons: implications regarding its inactivation in the extracellular space. J Neurobiol 23:656-670.
27. Réaux A, Fournie-Zaluski MC, David C, Zini S, Roques BP, Corvol P, Llorens-Cortes C (1999) Aminopeptidase A inhibitors as potential central antihypertensive agents. Proc Natl Acad Sci USA 96:13415-13420.
28. Roques BP (2000) Novel approaches to targeting neuropeptide systems. Trends Pharmacol Sci 21:475-483.
29. Rose C, Vargas F, Facchinetti P, Bourgeat P, Bambal RB, Bishop PB, Chan SMT, Moore ANJ, Ganellin CR, Schwartz J-C (1996) Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 380:403-411.
30. Saleh TM, Kombian SB, Zidichouski JA, Pittman QJ (1996) Peptidergic modulation of synaptic transmission in the parabrachial nucleus in vitro: importance of degradative enzymes in regulating synaptic efficacy. J Neurosci 16:6046-6055.
31. Sigvardt KA, Rothman BS, Brown RO, Mayeri E (1986) The bag cells of Aplysia as a multitransmitter system: identification of alpha bag cell peptide as a second neurotransmitter. J Neurosci 6:803-813.
32. Swensen AM, Marder E (2000) Multiple peptides converge to activate the same voltage-dependent current in a central pattern generating circuit. J Neurosci 20:6752-6759.
33. Swensen AM, Marder E (2001) Modulators with convergent cellular actions elicit distinct circuit outputs. J Neurosci 21:4050-4058.
34. Swensen AM, Golowasch J, Christie AE, Coleman MJ, Nusbaum MP, Marder E (2000) GABA and GABA responses in the stomatogastric ganglion of the crab Cancer borealis. J Exp Biol 203:2075-2092.
35. Vilim FS, Cropper EC, Price DA, Kupfermann I, Weiss KR (2000) Peptide cotransmitter release from motorneuron B16 in Aplysia californica: costorage, corelease, and functional implications. J Neurosci 20:2036-2042.
36. Wood DE, Stein W, Nusbaum MP (2000) Projection neurons with shared cotransmitters elicit different motor patterns from the same neural circuit. J Neurosci 20:8943-8953.
37. Zappulla JP, Wickham L, Bawab W, Yang X-F, Storozhuk MV, Castellucci VF, DesGroseillers L (1999) Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica. J Neurosci 19:4280-4292.
38. Zoli M, Jannson A, Sykova E, Agnati LF, Fuxe K (1999) Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol Sci 20:142-150.
39. Zupanc GKH (1996) Peptidergic transmission: from morphological correlates to functional implications. Micron 27:35-91.