Two patients with leprosy and the sudden appearance of inflammation in the skin and new sensory loss

PLoS Neglected Tropical Diseases

Volumn 3, Issue 9, 2009, Pages

  Franco Paredes, Carlos ^a,b   Jacob, Jesse T ^a   Stryjewska, Barbara ^c   Yoder, Leo ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^c U S DEPARTMENT OF HEALTH AND HUMAN SERVICES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AZATHIOPRINE; CLOFAZIMINE; CORTICOSTEROID; DAPSONE; INFLIXIMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PREDNISONE; RIFAMPICIN; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ACID FAST BACTERIUM; ADJUVANT THERAPY; ANAMNESIS; BORDERLINE LEPROSY; CONFERENCE PAPER; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG CHOICE; DRUG CONTRAINDICATION; DRUG DOSE REDUCTION; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG TREATMENT FAILURE; EARLY DIAGNOSIS; ERYTHEMA; ERYTHEMA NODOSUM LEPROSUM; FACIAL NERVE PARALYSIS; FOLLOW UP; FOOT EDEMA; GASTROINTESTINAL SYMPTOM; HAND EDEMA; HISTOPATHOLOGY; HUMAN; HYPERPIGMENTATION; IMMUNE RESPONSE; LEPROMATOUS LEPROSY; LEPROSY; LOW DRUG DOSE; LYMPHOCYTIC INFILTRATION; NEURITIS; NEUROPATHIC PAIN; NEUROPATHY; PAPULE; PARESTHESIA; PATHOPHYSIOLOGY; RECURRENT DISEASE; REVERSAL REACTION; SEDATION; SENSORY DYSFUNCTION; SIDE EFFECT; SKIN BIOPSY; SKIN DEFECT; SKIN INFLAMMATION; SKIN NODULE; SKIN PAIN; SKIN PLAQUE; SKIN ULCER; TERATOGENICITY; THROMBOSIS; TUBERCULOID LEPROSY;

EID: 70449507122     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000425     Document Type: Conference Paper

References (20)

1. Walker SL, Lockwood DNJ (2006) The clinical and immunological features of leprosy. Brit Med Bull 77 and 78: 103-121.
2. World Health Organization (2006) Global Strategy for Further Reducing the Leprosy Burden and Sustaining Leprosy Control Activities 2006-2010. Operational guidelines. Geneva: World Health Organization.
3. World Health Organization (2006) Global leprosy situation, beginning of 2008. Wkly Epidemiol Rec 2008 33: 293-300.
4. World Health Organization (2003) The final push strategy to eliminate leprosy as a public health problem. Questions and answers. Second Edition. Geneva: World Health Organization.
5. Yoder LJ (1996) Management of reactions in Hansen's disease. The Star. Carville (Louisiana): Gillis W. Long Hansen's Disease Program.
6. Scollard DM (2008) The biology of nerve injury in leprosy. Lepr Rev 79: 242-253.
7. Misch EA, Macdonald M, Ranjit C, Sapkota BR, Wells RD, et al. (2008) Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis 2: e231. doi:10.1371/journal.pntd.0000231. (Pubitemid 352002910)
8. Deps PD, Lockwood DNJ (2008) Leprosy occurring as immune reconstitution syndrome. Trans R Soc Trop Med Hyg102: 966-968.
9. Kahawita IP, Lockwood DNJ (2008) Towards understanding the pathology of erythema nodosum leprosum. Trans R Soc Trop Med Hyg 102: 329-337.
10. Walker SL, Waters MF, Lockwood DN (2007) The role of thalidomide in the management of erythema nodosum leprosum. Lepr Rev 78: 197-215. (Pubitemid 351171817)
11. van Brakel WH, Nicholls PG, Das L, Barkataki P, Suneetha S, et al. (2005) The INFIR cohort study: investigating prediction, detection, and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in North India. Lepr Rev 76: 14-34.
12. van Brakel WH, Nicholls PG, Wilder-Smith EP, Das L, Barkataki P (2008) Early Diagnosis of neuropathy in leprosy - comparing diagnostic tests in a large prospective study (the INFIR cohort study). PLoS Negl Trop Dis 2: e212. doi:10.1371/journal.pntd.0000212. (Pubitemid 352002929)
13. Pocaterra L, Jain S, Reddy R, Muzaffarullah S, Torres O, et al. (2006) Clinical course of erythema nodosum leprosum: An 11-year cohort study in Hyderabad, India. Am J Trop Med Hyg 74: 868-879. (Pubitemid 46774411)
14. Haslett PA, Roche P, Butlin R, Macdonald M, Shrestha N, et al. (2005) Effective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation. J Infect Dis 192: 2045-2053. (Pubitemid 41779200)
15. Scollard DM, Joyce MP, Gillis TP (2006) Development of leprosy and type 1 leprosy reactions after treatment with infliximab: A report of 2 cases. Clin Infect Dis 43: e19-e22.
16. Verma KK, Srivastava P, Minz A, Verma K (2006) Role of azathioprine in preventing recurrences in a patient of recurrent erythema nodosum leprosum. Lepr Rev 77: 225-229. (Pubitemid 44901766)
17. Burdick AE, Ramirez CC (2005) The role of mycophenolate mofetil in the treatment of leprosy reactions. Int J Lepr Other Mycobact Dis 73: 127-128.
18. Lockwood DNJ, Lucas SB, Desikan KV, Ebenezer G, Suneetha S, Nicholls P (2008) The histological diagnosis of leprosy type 1 reactions: identification of key variables and an analysis of the process of histological diagnosis. J Clin Pathol 61: 595-600. (Pubitemid 351678210)
19. Castro de Sena CB, Guedes Salgado C, Penabler Tavares CM, Vieira da Cruz CA, Xavier MB, et al. (2006) Cyclosporine A treatment of leprosy patients with chronic neuritis is associated with pain control and reduction in antibodies against nerve growth factor. Lepr Rev 77: 121-129.
20. Biosca G, Casallo s, Lopez-Velez R (2007) Methotrexate treatment for type 1 (reversal) leprosy reactions. Clin Infect Dis 45: e7-e9.