Accumulations of KIR+ T cells in the elderly

Blood

Volumn 114, Issue 16, 2009, Pages 3360-3361

  Pawelec, Graham ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 1; HISTONE; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL3;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL LEVEL; CYTOMEGALOVIRUS INFECTION; DEMETHYLATION; EPIGENETICS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCATION; HUMAN; IMMUNOSURVEILLANCE; LYMPHOCYTE CLONE; MOLECULAR MECHANICS; NOTE; PRIORITY JOURNAL; PROMOTER REGION; STOICHIOMETRY; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION REGULATION;

EID: 70449502131     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-08-235259     Document Type: Note

References (7)

1. Li G, Yu M, Weyand CM, Goronzy JJ. Epigenetic regulation of killer immunoglobulin-like receptor expression in Tcells. Blood. 2009;114(16):3422- 3430.
2. Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Opin Immunol. 2009;21(4):440-445. (Pubitemid 350070409)
3. Franceschi C, Bonafè M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine. 2000;18(16):1717-1720. (Pubitemid 30109535)
4. Bryl E, Vallejo AN, Weyand CM, Goronzy JJ. Down-regulation of CD28 expression by TNF-alpha. J Immunol. 2001;167(6):3231-3238.
5. Appay V, Dunbar PR, Callan M, et al. Memory CD8+ Tcells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8(4):379-385. (Pubitemid 34407033)
6. Chidrawar S, Khan N, Wei W, et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol. 2009;155(3):423-432.
7. Hadrup SR, Strindhall J, Køllgaard T, et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol. 2006;176(4):2645-2653. (Pubitemid 43201717)