An exploratory study of the effect of using high-mix biphasic insulin aspart in people with type 2 diabetes

Diabetes, Obesity and Metabolism

Volumn 11, Issue 7, 2009, Pages 680-687

  Dashora, U K ^a   Ashwell, S G ^a   Home, P D ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Biphasic insulin aspart; High mix; Premix insulin; Type 2 diabetes

Indexed keywords

C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN ASPART; ISOPHANE INSULIN; MIXTARD 30; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFECT; DRUG USE; EXPLORATORY RESEARCH; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; MALE; MAXIMUM PLASMA CONCENTRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 70449473101     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.01024.x     Document Type: Article

References (18)

1. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352:837-853.
2. Ohkubo Y, Kishikawa H, Araki E. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin dependent diabetes mellitus: a randomised prospective 6 years study. Diabetes Res Clin Pract 1995, 28:103-117.
3. United Kingdom Prospective Diabetes Study, overview of 6 year's therapy of type 2 diabetes: a progressive disease. Diabetes 1995, 44:1249-1258.
4. Boehm BO, Home PD, Behrend C, Kamp NM, Lindholm A. Premixed insulin aspart 30 vs. premixed human insulin 30/70 twice daily: a randomized trial in type 1 and type 2 diabetic patients. Diabet Med 2002, 19:393-399.
5. Roach P, Yue L, Arora V. Improved postprandial glycemic control during treatment with Humalog Mix25, a novel protamine-based insulin lispro formulation. Diabetes Care 1999, 22:1258-1261.
6. Boehm BO, Vaz JA, Brbndsted B, Home PD. Long-term efficacy and safety of biphasic insulin aspart in patients with type 2 diabetes. Eur J Intern Med 2004, 15:496-502.
7. Heller SR, Colagiuri S, Vaaler S. Hypoglycaemia with insulin aspart: a double-blind, randomised, crossover trial in subjects with type 1 diabetes. Diabet Med 2004, 21:769-775.
8. Home PD, Lindholm A, Riis A. Insulin aspart vs human insulin in the management of long-term blood glucose control in type 1 diabetes mellitus: a randomized controlled trial. Diabet Med 2000, 17:762-770.
9. Clements MR, Tits J, Kinsley BT, Råstam J, Friberg HH, Ligthelm RJ. Improved glycaemic control of thrice-daily biphasic insulin aspart compared with twice-daily biphasic human insulin a randomized, open-label trial in patients with type 1 or type 2 diabetes. Diabetes Obes Metab 2008, 10:229-237.
10. Ejskjaer N, Rasmussen M, Kamp N, Lindholm A, Christiansen JS. Comparison of thrice daily 'high' vs 'medium' premixed insulin aspart with respect to evening and overnight glycaemic control in patients with type 2 diabetes. Diabetes Obes Metab 2003, 5:438-445.
11. Garber AJ, Wahlen J, Wahl T. Attainment of glycaemic goals in type 2 diabetes with once-, twice-, or thrice-daily dosing with biphasic insulin aspart 70/30 (The 1-2-3 study). Diabetes Obes Metab 2006, 8:58-66.
12. Diabetes Mellitus: Report of a WHO Study Group 1985, 1-98. Geneva, World Health Organization, Technical Report Series 727
13. Yki-Järvinen H, Kauppinen-Mäkelin R, Tiikkainen M. Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study. Diabetologia 2006, 49:442-451.
14. Brunelle RL, Llewelyn J, Anderson JH, Gale EA, Koivisto VA. Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes. Diabetes Care 1998, 21:1726-1731.
15. Heller S, Amiel S, Mansell P. Effect of the fast-acting insulin analog lispro on the risk of nocturnal hypoglycaemia during intensified insulin therapy. Diabetes Care 1999, 22:1607-1611.
16. Holleman F, Schmitt H, Rottiers R, Rees A, Symanowski S, Anderson J. Reduced frequency of severe hypoglycaemia and coma in well-controlled IDDM patients treated with insulin lispro. Diabetes Care 1997, 20:1827-1832.
17. Guideline for Management of Postmeal Glucose 2007, http://www.idf.org, Brussels, International Diabetes Federation, Available from URL, Accessed 31 December 2008
18. Home PD, Barriocanal L, Lindholm A. Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers. Eur J Clin Pharmacol 1999, 55:199-203.