A new technique for precisely and accurately measuring lumbar spine bone mineral density in mice using clinical dual energy X-ray absorptiometry

Toxicology Mechanisms and Methods

Volumn 19, Issue 3, 2009, Pages 225-231

  Katikaneni, Ranjitha ^a   Ponnapakkam, Adharsh ^a   Miller, Eric ^a   Ponnapakkam, Tulasi ^a   Gensure, Robert C ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

Accuracy; Bone mineral density (BMD); DXA; Mice; Precision

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BONE MINERAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; IN VIVO STUDY; LUMBAR SPINE; MEASUREMENT ERROR; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL;

ABSORPTIOMETRY, PHOTON; ANIMALS; BONE DENSITY; FEMALE; LUMBAR VERTEBRAE; MICE; MICE, INBRED C57BL; OSTEOPOROSIS; REPRODUCIBILITY OF RESULTS;

ANIMALIA; MUS;

EID: 70449382332     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510802499030     Document Type: Article

References (13)

1. Cheng, S., Tylavsky, F., and Carbone, L. 1997. Utility of ultrasound to assess risk of fracture. J. Am. Geriatr. Soc. 45:1382-1394.
2. Di Leo, C., Tarolo, G. L., Bagni, B., Bestetti, A., Tagliabue, L., Pietrogrande, L., and Pepe, L. 2002. Peripheral quantitative Computed Tomography (PQCT) in the evaluation of bone geometry, biomechanics and mineral density in postmenopausal women. Radiol. Med. (Torino) 103:233-241.
3. Fogelman, I., and Wahner, H. 1994. The Evaluation of Osteoporosis: Dual Energy X-ray Absorbtiometry in Clinical Practice. Martin Dunitz. London.
4. Gala Paniagua, J., Diaz-Curiel, M., de la Piedra Gordo, C., Castilla Reparaz, C., and Torralbo Garcia, M. 1998. Bone mass assessment in rats by dual energy X-ray absorptiometry. Br. J. Radiol. 71:754-758.
5. Hofker, M. 2003. Introduction: the use of transgenic mice in biomedical research. Methods Mol. Biol. 209:1-8.
6. Iida-Klein, A., Lu, S. S., Yokoyama, K., Dempster, D. W., Nieves, J. W., and Lindsay, R. 2003. Precision, accuracy, and reproducibility of dual X-ray absorptiometry measurements in mice in vivo. J. Clin. Densitom. 6:25-33.
7. Lochmuller, E. M., Jung, V., Weusten, A., Wehr, U., Wolf, E., and Eckstein, F. 2001. Precision of high-resolution dual energy X-ray absorptiometry of bone mineral status and body composition in small animal models. Eur. Cell Mater. 1:43-51.
8. Moore, D. M. 1995. Mice. In: Experimental Animal in Biomedical Research. Care, Husbandry and Well-Being-An Overview by Species. CRC Press. Florida, USA. pp. 281-308.
9. Nagy, T. R., and Clair, A. L. 2000. Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice. Obes. Res. 8:392-398.
10. Nagy, T. R., Prince, C. W., and Li, J. 2001. Validation of peripheral dual-energy X-ray absorptiometry for the measurement of bone mineral in intact and excised long bones of rats. J. Bone Miner. Res. 16:1682-1687.
11. Ponnapakkam, T., Katikaneni, R., Ponnapakkam, A., Miller, E., and Gensure, R. 2008. Monthly administration of a novel parathyroid hormone-collagen binding domain fusion protein increases bone mineral density by more than 10 percent in normal mice. Paper read at Ochsner's Fifth Annual Research Night, May 13, 2008, at Ochsner Clinic Foundation, Jefferson Highway, New Orleans, Louisiana.
12. Ponnapakkam, T., Sakon, J., Matsushita, O., and Gensure, R. 2007. Weekly administration of a novel parathyroid hormone-collagen binding domain fusion protein increases bone mioneral density by more than 15 percent in normal mice. Paper read at ASBMR 29th Annual Meeting, September 16-19th, 2007, at Hawaii Convention Center, Honolulu, Hawaii.
13. Vonken, W., and Hofker, M. 2005. Transgenic mice in biomedical research. In: Molecular Cell Biology and Molecular Medicine, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. p. 508.