Direct repeat 6 from human herpesvirus-6b encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Schleimann, Mariane H ^a   Møller, Janni M L ^a   Kofod Olsen, Emil ^a   Höllsberg, Per ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE; DIRECT REPEAT 6 PROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; PHOSPHONOACETIC ACID; PROTEIN P53; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN; DNA BINDING PROTEIN; P41 PROTEIN, HUMAN HERPESVIRUS 6;

ARTICLE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE LOCATION; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; VIRUS REPLICATION; ANIMAL; CELL NUCLEUS; GENETICS; HUMAN HERPESVIRUS 6; METABOLISM; METHODOLOGY; NUCLEOTIDE REPEAT; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; VIROLOGY; VIRUS GENE; VIRUS GENOME;

HERPESVIRIDAE; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 6A; HUMAN HERPESVIRUS 6B; MUS MUSCULUS;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; DNA, VIRAL; DNA-BINDING PROTEINS; GENES, VIRAL; GENOME, VIRAL; HERPESVIRUS 6, HUMAN; HUMANS; MICE; MICROSCOPY, CONFOCAL; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, NUCLEIC ACID; TUMOR SUPPRESSOR PROTEIN P53; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 70449380737     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007457     Document Type: Article

References (20)

1. Braun DK, Dominguez G, Pellett PE (1997) Human herpesvirus 6. Clin Microbiol Rev 10: 521-567.
2. Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, et al. (2005) A population-based study of primary human herpesvirus 6 infection. N Engl J Med 352: 768-776.
3. Yoshikawa T, Suga S, Asano Y, Yazaki T, Kodama H, et al. (1989) Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. Pediatrics 84: 675-677.
4. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, et al. (1988) Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1: 1065-1067.
5. Ahlqvist J, Fotheringham J, Akhyani N, Yao K, Fogdell-Hahn A, et al. (2005) Differential tropism of human herpesvirus 6 (HHV-6) variants and induction of latency by HHV-6A in oligodendrocytes. J Neurovirol 11: 384-394.
6. De Bolle L, Van Loon J, De Clercq E, Naesens L (2005) Quantitative analysis of human herpesvirus 6 cell tropism. J Med Virol 75: 76-85.
7. Aberle SW, Mandl CW, Kunz C, Popow-Kraupp T (1996) Presence of human herpesvirus 6 variants A and B in saliva and peripheral blood mononuclear cells of healthy adults. J Clin Microbiol 34: 3223-3225.
8. Dominguez G, Dambaugh TR, Stamey FR, Dewhurst S, Inoue N, et al. (1999) Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73: 8040-8052.
9. Gompels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, et al. (1995) The DNA Sequence of Human Herpesvirus-6: Structure, Coding Content, and Genome Evolution. Virology 209: 29-51.
10. Takemoto M, Mori Y, Ueda K, Kondo K, Yamanishi K (2004) Productive human herpesvirus 6 infection causes aberrant accumulation of p53 and prevents apoptosis. J Gen Virol 85: 869-879.
11. De Bolle L, Hatse S, Verbeken E, De Clercq E, Naesens L (2004) Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle. FEBS Lett 560: 25-29.
12. Oster B, Bundgaard B, Hollsberg P (2005) Human Herpesvirus 6B Induces Cell Cycle Arrest Concomitant with p53 Phosphorylation and Accumulation in T Cells. J Virol 79: 1961-1965.
13. Cotter TG (2009) Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 9: 501-507.
14. Thompson J, Choudhury S, Kashanchi F, Doniger J, Berneman Z, et al. (1994) A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1. Oncogene 9: 1167-1175.
15. Kashanchi F, Araujo J, Doniger J, Muralidhar S, Hoch R, et al. (1997) Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53. Oncogene 14: 359-367.
16. Kashanchi F, Thompson J, Sadaie MR, Doniger J, Duvall J, et al. (1994) Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein expressed from the SalI-L fragment of human herpesvirus 6. Virology 201: 95-106.
17. Quadt I, Gunther AK, Voss D, Schelhaas M, Knebel-Morsdorf D (2006) TATA-binding protein and TBP-associated factors during herpes simplex virus type 1 infection: localization at viral DNA replication sites. Virus Res 115: 207-213.
18. Quinlan MP, Chen LB, Knipe DM (1984) The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell 36: 857-868.
19. Turcanova VL, Bundgaard B, Hollsberg P (2009) Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen. J Clin Virol 46: 15-19.
20. Oster B, Hollsberg P (2002) Viral Gene Expression Patterns in Human Herpesvirus 6B-Infected T Cells. J Virol 76: 7578-7586.