Development and validation of a HPLC-MS-MS method for quantification of metronidazole in human plasma

Journal of Chromatographic Science

Volumn 47, Issue 9, 2009, Pages 781-784

  Silva, Marina ^a   Schramm, Simone ^a   Kano, Eunice ^a   Koono, Eunice ^a   Porta, Valentina ^a   Serra, Cristina ^a  

^a USP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70449366124     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/47.9.781     Document Type: Article

References (16)

1. C. Sagan, A. Salvador, D. Dubreuil, P.P. Poulet, D. Duffaut and I. Brumpt. Simultaneous determination of metronidazole and spiramycin I in human plasma, saliva and gingival crevicular fulid by LC-MS/MS. J. Pharm. Biomed. Anal. 38: 298-306 (2005).
2. A. Menelau, A.A. Somogyi, M.L. Barclay, and F. Bochner. Simultaneous quantification of amoxicillin and metronidazole in plasma using high-performance liquid chromatography with photodiode array detection. J. Chromatogr. B 731: 261-266 (1999).
3. C. Hoffmann, N. Focke, G. Franke, M. Zschiesche, and W. Siegmund. Comparative bioavailability of metronidazole formulations (Vagimid) after oral and vaginal administration. Int. J. Clin. Pharmacol. Ther. 33: 232-239 (1995).
4. P.T. Pollak. A liquid chromatography assay for the study of serum and gastric juice metronidazole concentrations in the treatment of Helicobacter pylori. Ther. Drug Monitoring. 18: 678-687 (1996).
5. J.I.D. Wibawa, P.N. Shaw, and D.A. Barett. Quantification of metronidazole in small-volume biological samples using narrow-bore high-performance liquid chromatography. J. Chromatogr. B 761: 213-219 (2001).
6. P.K.F. Yeung, R. Little, Y.Q. Jiang, S.J. Buckley, P.T. Pollak, H. Kapoor, and S.J.O. Veldhuyzen van Zanten. A simple high performance liquid chromatography assay for simultaneous determination of omprazole and metronidazole in human plasma and gastric fluid. J. Pharm. Biomed. Anal. 17: 1393-1398 (1998).
7. J.G. Hardman; L.E. Limbird, and A.G. Gilman. As bases farmacológicas da terapêutica. 10 ed. Rio de Janeiro, RJ, 2001, pp. 1506.
8. K.K. Midha, I.J. McGilveray and J.K. Cooper. Determination of therapeutic levels of metronidazole in plasma by gas-liquid Chromatography. J. Chromatogr. 87: 491-497(1973).
9. T.G. Nascimento, E.J. Oliveira, and R.O. Macedo. Simultaneous determination of ranitine and metronidazole in human plasma using high performance liquid chromatography with diode array detection. J. Pharm. Biomed. Anal. 37: 777-783 (2005).
10. N.M. Idkaidek and N.M. Najib. Enhancement of oral absorption of metronidazole suspensions in humans. Eur. J. Pharm. Ther. 50: 213-216 (2000).
11. S. Fraselle, V. Derop, J-M. Degroodt, and J.V. Loco. Validation of a method for detection and confirmation of nitroimidazoles and the corresponding hydroxyl metabolites in pig plasma by high performace liquid-chromatography-tandem mass spectrometry. Anal. Chim. Acta. 586: 383-393 (2007).
12. V. Porta, S.G. Schramm, E.K. Kano, E.E. Koono, Y.P. Armando, K. Fukuda, and C.H.R. Serra. HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies. J. Pharm. Biomed. Anal. 46: 143-147 (2008).
13. Y.P. Armando, S.G. Schramm, M.F. Silva, E.K. Kano, E.E.M. Koono, V. Porta, and C.H.R. Serra. Bioequivalence assay between orally disintegrating and conventional tablet formulations in healthy volunteers. Int. J. Pharm. 366: 149-153 (2009).
14. M.J. Galmier, A.M. Frasey, M. Bastide, E. Beyssac, J. Petit, J.M. Aiache, and C. Lartigue-Mattei. Simple and sensitive method for determination of metroni-dazole in human serum by high-performance liquid chromatography. J. Chromatogr. B 720: 239-243 (1998).
15. M.J. Jessa, D.A. Barrett, P.N. Shaw, and R.C. Spiller. Rapid and selective high-performance liquid chromatographic method for the determination of metronidazole and its active metabolite in human plasma, saliva and gastric juice. J. Chromatogr. B 677: 374-379 (1996).
16. J. Spénard, C. Aumais, J. Massicotte, J.S. Brunet, C. Tremblay, M. Grace, and M. Lefebvre. Effects of food and formulation on the relative bioavailability of bismuth biskalcitrate, metronidazole, and tetracycline given for Helicobacter pylori eradication. British J. Clin. Pharm. 60(4): 374-377 (2005).