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Volumn 94, Issue 11, 2009, Pages 1569-1580

Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - Analyses of cases from two prospective randomized clinical trials

(20)  Bernd, Heinz Wolfram a   Ziepert, Marita b   Thorns, Christoph a   Klapper, Wolfram c   Wacker, Hans Heinrich c   Hummel, Michael d   Stein, Harald d   Hansmann, Martin Leo e   Ott, German f,l   Rosenwald, Andreas f   Müller Hermelink, Hans Konrad f   Barth, Thomas F E g   Möller, Peter g   Cogliatti, Sergio B h   Pfreundschuh, Michael i   Schmitz, Norbert j   Trümper, Lorenz k   Höller, Silvia f,m   Löffler, Markus b   Feller, Alfred C a  


Author keywords

Diffuse large B cell lymphoma; HLA DR; Immunoblastic lymphoma; Prognosis

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; HLA DR ANTIGEN; INTERFERON REGULATORY FACTOR 4; PREDNISOLONE; PROTEIN BCL 6; VINCRISTINE;

EID: 70449365381     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.008862     Document Type: Article
Times cited : (40)

References (58)
  • 4
    • 0037142053 scopus 로고    scopus 로고
    • Lymphoma/Leukemia Molecular Profiling Project. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. Lymphoma/Leukemia Molecular Profiling Project. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002;346:1937-1947
    • (2002) N Engl J Med , vol.346 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3    Connors, J.M.4    Campo, E.5    Fisher, R.I.6
  • 6
    • 3242802160 scopus 로고    scopus 로고
    • Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: Results of the NHL-B2 trial of the DSHNHL
    • German High-Grade Non-Hodgkin's Lymphoma Study Group
    • Pfreundschuh M, Trümper L, Kloess M, Schmits R, Feller AC, Rübe C, et al. German High-Grade Non-Hodgkin's Lymphoma Study Group. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of elderly patients with aggressive lymphomas: results of the NHL-B2 trial of the DSHNHL. Blood 2004;104:634-641
    • (2004) Blood , vol.104 , pp. 634-641
    • Pfreundschuh, M.1    Trümper, L.2    Kloess, M.3    Schmits, R.4    Feller, A.C.5    Rübe, C.6
  • 7
    • 3042813710 scopus 로고    scopus 로고
    • Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: Results of the NHL-B1 trial of the DSHNHL
    • German High-Grade Non- Hodgkin's Lymphoma Study Group
    • Pfreundschuh M, Trümper L, Kloess M, Schmits R, Feller AC, Rudolph C, et al. German High-Grade Non- Hodgkin's Lymphoma Study Group. Two-weekly or 3-weekly CHOP chemotherapy with or without etoposide for the treatment of young patients with good-prognosis (normal LDH) aggressive lymphomas: results of the NHL-B1 trial of the DSHNHL. Blood 2004;104:626-633
    • (2004) Blood , vol.104 , pp. 626-633
    • Pfreundschuh, M.1    Trümper, L.2    Kloess, M.3    Schmits, R.4    Feller, A.C.5    Rudolph, C.6
  • 8
    • 36749013021 scopus 로고    scopus 로고
    • Distribution patterns of dendritic cells and T cells in diffuse large B-cell lymphomas correlate with prognoses
    • DOI 10.1158/1078-0432.CCR-07-0504
    • Chang KC, Huang GC, Jones D, Lin YH. Distribution patterns of dendritic cells and T cells in diffuse large B-cell lymphomas correlate with prognoses. Clin Cancer Res 2007; 13:6666-6672 (Pubitemid 350206802)
    • (2007) Clinical Cancer Research , vol.13 , Issue.22 , pp. 6666-6672
    • Chang, K.-C.1    Huang, G.-C.2    Jones, D.3    Lin, Y.-H.4
  • 9
    • 0023816791 scopus 로고
    • HLA-DR (Ia) immune phenotype predicts outcome for patients with diffuse large cell lymphoma
    • Miller TP, Lippman SM, Spier CM, Slymen DJ, Grogan TM. HLA-DR (Ia) immune phenotype predicts outcome for patients with diffuse large cell lymphoma. J Clin Invest 1988;82:370-372
    • (1988) J Clin Invest , vol.82 , pp. 370-372
    • Miller, T.P.1    Lippman, S.M.2    Spier, C.M.3    Slymen, D.J.4    Grogan, T.M.5
  • 10
    • 0026356542 scopus 로고
    • Prediction of outcome in diffuse large cell lymphoma by the major histocompatibility complex class I (HLA-A, -B, -C) and class II (HLADR, -DP, -DQ) phenotype
    • Rybski JA, Spier CM, Miller TP, et al. Prediction of outcome in diffuse large cell lymphoma by the major histocompatibility complex class I (HLA-A, -B, -C) and class II (HLADR, -DP, -DQ) phenotype. Leuk Lymphoma 1991;6:31-38
    • (1991) Leuk Lymphoma , vol.6 , pp. 31-38
    • Rybski, J.A.1    Spier, C.M.2    Miller, T.P.3
  • 12
    • 33947660517 scopus 로고    scopus 로고
    • HLA-DR protein status predicts survival in patients with diffuse large B-cell lymphoma treated on the MACOP-B chemotherapy regimen
    • DOI 10.1080/10428190601078605, PII 773541465
    • Rimsza LM, Farinha P, Fuchs DA, Masoudi H, Connors JM, Gascoyne RD. HLA-DR protein status predicts survival in patients with diffuse large B-cell lymphoma treated on the MACOP-B chemotherapy regimen. Leuk Lymphoma 2007;48:542-546 (Pubitemid 46487763)
    • (2007) Leukemia and Lymphoma , vol.48 , Issue.3 , pp. 542-546
    • Rimsza, L.M.1    Farinha, P.2    Fuchs, D.A.3    Masoudi, H.4    Connors, J.M.5    Gascoyne, R.D.6
  • 15
    • 0030029443 scopus 로고    scopus 로고
    • Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma
    • Hermine O, Haioun C, Lepage E, d'Agay MF, Briere J, Lavignac C, et al. Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Blood 1996;7:265-272
    • (1996) Blood , vol.7 , pp. 265-272
    • Hermine, O.1    Haioun, C.2    Lepage, E.3    D'Agay, M.F.4    Briere, J.5    Lavignac, C.6
  • 18
    • 0021908398 scopus 로고
    • Chemically activated glass slides for frozen sections and their use in autoantibody diagnosis
    • Stocker K, Stocker W, Ritter-Frank Y, Scriba PC. Chemically activated glass slides for frozen sections and their use in autoantibody diagnosis. Acta Histochem 1985; Suppl 31: 283-294
    • (1985) Acta Histochem , Issue.SUPPL. 31 , pp. 283-294
    • Stocker, K.1    Stocker, W.2    Ritter-Frank, Y.3    Scriba, P.C.4
  • 19
    • 0021984969 scopus 로고
    • Rational histochemistry using a new microanalytic technic
    • Stocker W. Rational histochemistry using a new microanalytic technic. Acta Histochem 1985; (Suppl 31): 269-281
    • (1985) Acta Histochem , Issue.SUPPL. 31 , pp. 269-281
    • Stocker, W.1
  • 20
    • 0023543522 scopus 로고
    • Monoclonal antibody Ki-B3 detects a formalin resistant antigen on normal and neoplastic B cells
    • Feller AC, Wacker HH, Moldenhauer G, Radzun HJ, Parwaresch MR. Monoclonal antibody Ki-B3 detects a formalin resistant antigen on normal and neoplastic B cells. Blood 1987;70:629-636 (Pubitemid 18027391)
    • (1987) Blood , vol.70 , Issue.3 , pp. 629-636
    • Feller, A.C.1    Wacker, H.H.2    Moldenhauer, G.3    Radzun, H.J.4    Parwaresch, M.R.5
  • 21
    • 70449414196 scopus 로고    scopus 로고
    • Database at
    • HLDA Database at: http://www99. mh-hannover.de/aktuelles/projekte/ hlda7/hldabase/select.htm
  • 22
    • 0026019963 scopus 로고
    • Ki-B5: A monoclonal antibody unrelated to CD45 recognizes normal and neoplastic human B cells in routine paraffin sections
    • Hansmann ML, Wacker HH, Gralla J, Lumbeck H, Kossmahl M, Heidebrecht HJ, et al. Ki-B5: a monoclonal antibody unrelated to CD45 recognizes normal and neoplastic human B cells in routine paraffin sections. Blood 1991;77: 809-817
    • (1991) Blood , vol.77 , pp. 809-817
    • Hansmann, M.L.1    Wacker, H.H.2    Gralla, J.3    Lumbeck, H.4    Kossmahl, M.5    Heidebrecht, H.J.6
  • 23
    • 0026700204 scopus 로고
    • Monoclonal antibody OPD4 detects neoplastic T cells but does not distinguish between CD4 and CD8 neoplastic T cells in paraffin tissue sections
    • Chadburn A, Husain S, Knowles DM. Monoclonal antibody OPD4 detects neoplastic T cells but does not distinguish between CD4 and CD8 neoplastic T cells in paraffin tissue sections. Hum Pathol 1992;23:940-947
    • (1992) Hum Pathol , vol.23 , pp. 940-947
    • Chadburn, A.1    Husain, S.2    Knowles, D.M.3
  • 27
    • 33845386258 scopus 로고    scopus 로고
    • Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival
    • Haarer CF, Roberts RA, Frutiger YM, Grogan TM, Rimsza LM. Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival. Arch Pathol Lab Med 2006;130:1819-1824
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 1819-1824
    • Haarer, C.F.1    Roberts, R.A.2    Frutiger, Y.M.3    Grogan, T.M.4    Rimsza, L.M.5
  • 28
    • 27244437953 scopus 로고    scopus 로고
    • Large cleaved and immunoblastic lymphoma may represent two distinct clinicopathologic entities within the group of diffuse large B-cell lymphomas
    • DOI 10.1200/JCO.2005.15.503
    • De Paepe P, Achten R, Verhoef G, Wlodarska I, Stul M, Vanhentenrijk V, et al. Large cleaved and immunoblastic lymphoma may represent two distinct clinicopathologic entities within the group of diffuse large B-cell lymphomas. J Clin Oncol 2005;23:7060-7068 (Pubitemid 46260293)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.28 , pp. 7060-7068
    • De Paepe, P.1    Achten, R.2    Verhoef, G.3    Wlodarska, I.4    Stul, M.5    Vanhentenrijk, V.6    Praet, M.7    De Wolf-Peeters, C.8
  • 29
    • 34447331434 scopus 로고    scopus 로고
    • Immunophenotype as prognostic factor for diffuse large B-cell lymphoma in patients undergoing clinical risk-adapted therapy
    • DOI 10.1093/annonc/mdm012
    • Veelken H, Vik Dannheim S, Schulte Moenting J, Martens UM, Finke J, Schmitt-Graeff A. Immunophenotype as prognostic factor for diffuse large B-cell lymphoma in patients undergoing clinical risk-adapted therapy. Ann Oncol 2007;18:931-939 (Pubitemid 47054092)
    • (2007) Annals of Oncology , vol.18 , Issue.5 , pp. 931-939
    • Veelken, H.1    Vik Dannheim, S.2    Schulte Moenting, J.3    Martens, U.M.4    Finke, J.5    Schmitt-Graeff, A.6
  • 31
    • 33744960411 scopus 로고    scopus 로고
    • Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling
    • Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TF, et al. Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med 2006;354:2419-2430
    • (2006) N Engl J Med , vol.354 , pp. 2419-2430
    • Hummel, M.1    Bentink, S.2    Berger, H.3    Klapper, W.4    Wessendorf, S.5    Barth, T.F.6
  • 33
    • 57149089307 scopus 로고    scopus 로고
    • Lymphoma/Leukemia Molecular Profiling Project. Stromal gene signatures in large-B-cell lymphomas
    • Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, et al. Lymphoma/Leukemia Molecular Profiling Project. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med 2008;359:2313-2323
    • (2008) N Engl J Med , vol.359 , pp. 2313-2323
    • Lenz, G.1    Wright, G.2    Dave, S.S.3    Xiao, W.4    Powell, J.5    Zhao, H.6
  • 34
    • 0023222449 scopus 로고
    • Defective expression of MHC class I antigens is frequent in B-cell lymphomas of high-grade malignancy
    • DOI 10.1002/ijc.2910400107
    • Möller P, Herrmann B, Moldenhauer G, Momburg F. Defective expression of MHC class I antigens is frequent in B-cell lymphomas of high-grade malignancy. Int J Cancer 1987;40:32-39 (Pubitemid 17099966)
    • (1987) International Journal of Cancer , vol.40 , Issue.1 , pp. 32-39
    • Moller, P.1    Herrmann, B.2    Moldenhauer, G.3    Momburg, F.4
  • 35
    • 0023521156 scopus 로고
    • B-cell lymphomas of high-grade malignancy frequently lack HLA-DR, -DP and -DQ antigens and associated invariant chain
    • DOI 10.1002/ijc.2910400504
    • Momburg F, Herrmann B, Moldenhauer G, Moller P. B-cell lymphomas of high-grade malignancy frequently lack HLA-DR, -DP and - DQ antigens and associated invariant chain. Int J Cancer 1987;40:598-603. (Pubitemid 18003845)
    • (1987) International Journal of Cancer , vol.40 , Issue.5 , pp. 598-603
    • Momburg, F.1    Herrmann, B.2    Moldenhauer, G.3    Moller, P.4
  • 36
    • 0019986751 scopus 로고
    • Antigen presentation by human B cells: T cell proliferation induced by Epstein Barr virus B lymphoblastoid cells
    • Issekutz T, Chu E, Geha RS. Antigen presentation by human B cells: T cell proliferation induced by Epstein Barr virus B lymphoblastoid cells. J Immunol 1982;129:1446-1450 (Pubitemid 12031069)
    • (1982) Journal of Immunology , vol.129 , Issue.4 , pp. 1446-1450
    • Issekutz, T.1    Chu, E.2    Geha, R.S.3
  • 37
    • 0022530967 scopus 로고
    • Autologous B lymphoblastoid cell lines and long-term cultured T cells as stimulators in the mixed lymphocyte reaction: Analysis of the role of HLA class II antigens as stimulatory molecules
    • Santoli D, Radka SF, Igarashi M, Kreider BL, Ferrone S. Autologous B lymphoblastoid cell lines and longterm cultured T cells as stimulators in the mixed lymphocyte reaction: analysis of the role of HLA class II antigens as stimulatory molecules. J Immunol 1986;137:400-407 (Pubitemid 16045058)
    • (1986) Journal of Immunology , vol.137 , Issue.2 , pp. 400-407
    • Santoli, D.1    Radka, S.F.2    Igarashi, M.3
  • 38
    • 0033759326 scopus 로고    scopus 로고
    • Loss of B7.2 (CD86) and intracellular adhesion molecule 1 (CD54) expression is associated with decreased tumor-infiltrating T lymphocytes in diffuse B-cell large-cell lymphoma
    • Stopeck AT, Gessner A, Miller TP, Hersh EM, Johnson CS, Cui H, et al. Loss of B7.2 (CD86) and intracellular adhesion molecule 1 (CD54) expression is associated with decreased tumor-infiltrating T lymphocytes in diffuse B-cell large-cell lymphoma. Clin Cancer Res 2000;6:3904-3909 (Pubitemid 30807081)
    • (2000) Clinical Cancer Research , vol.6 , Issue.10 , pp. 3904-3909
    • Stopeck, A.T.1    Gessner, A.2    Miller, T.P.3    Hersh, E.M.4    Johnson, C.S.5    Cui, H.6    Frutiger, Y.7    Grogan, T.M.8
  • 39
    • 54049147790 scopus 로고    scopus 로고
    • Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP
    • Rimsza LM, Leblanc ML, Unger JM, Miller TP, Grogan TM, Persky DO, et al. Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP. Blood 2008;112:3425-3433
    • (2008) Blood , vol.112 , pp. 3425-3433
    • Rimsza, L.M.1    Leblanc, M.L.2    Unger, J.M.3    Miller, T.P.4    Grogan, T.M.5    Persky, D.O.6
  • 40
    • 0034669309 scopus 로고    scopus 로고
    • Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immuneprivileged sites
    • Riemersma SA, Jordanova ES, Schop RF. Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immuneprivileged sites. Blood 2000; 96:3569-3577
    • (2000) Blood , vol.96 , pp. 3569-3577
    • Riemersma, S.A.1    Jordanova, E.S.2    Schop, R.F.3
  • 42
    • 0018968186 scopus 로고
    • Immunologic phenotype in 30 patients with diffuse large-cell lymphoma
    • Warnke R, Miller R, Grogan T, Pederson M, Dilley J, Levy R. Immunologic phenotype in 30 patients with diffuse large-cell lymphoma. N Engl J Med 1980;303:293-300. (Pubitemid 10040016)
    • (1980) New England Journal of Medicine , vol.303 , Issue.6 , pp. 293-300
    • Warnke, R.1    Miller, R.2    Grogan, T.3
  • 44
    • 0020033928 scopus 로고
    • National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project
    • No authors listed
    • [No authors listed] National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project. Cancer 1982;49:2112-2135
    • (1982) Cancer , vol.49 , pp. 2112-2135
  • 45
    • 0021144642 scopus 로고
    • Clinical and prognostic relevance of the Kiel classification of non-Hodgkin lymphomas: Results of a prospective multicenter study by the Kiel Lymphoma Study Group
    • Brittinger G, Bartels H, Common H, Duhmke E, Fulle HH, Gunzer U, et al. Clinical and prognostic relevance of the Kiel classification of non- Hodgkin lymphomas: results of a prospective multicenter study by the Kiel Lymphoma Study Group. Hematol Oncol 1984;2:269-306. (Pubitemid 14044531)
    • (1984) Hematological Oncology , vol.2 , Issue.3 , pp. 269-306
    • Brittinger, G.1    Bartels, H.2    Common, H.3
  • 47
    • 0023498147 scopus 로고
    • Do pathologic features predict prognosis in diffuse large B-cell lymphoma?
    • Vago JF, Weisenburger DD, Armitage JO. Do pathologic features predict prognosis in diffuse large B-cell lymphoma? Hematol Pathol 1987;1:217-225
    • (1987) Hematol Pathol , vol.1 , pp. 217-225
    • Vago, J.F.1    Weisenburger, D.D.2    Armitage, J.O.3
  • 48
    • 0020462297 scopus 로고
    • The clinical significance of the morphological subdivision of diffuse "histocytic" lymphoma: A study of 162 patients treated by the Southwest Oncology Group
    • Nathwani BN, Dixon DO, Jones SE, Hartsock RJ, Rebuck JW, Byrne GE Jr, et al. The clinical significance of the morphological subdivision of diffuse "histocytic" lymphoma: a study of 162 patients treated by the Southwest Oncology Group. Blood 1982;60:1068-1074
    • (1982) Blood , vol.60 , pp. 1068-1074
    • Nathwani, B.N.1    Dixon, D.O.2    Jones, S.E.3    Hartsock, R.J.4    Rebuck, J.W.5    Byrne Jr., G.E.6
  • 50
  • 53
    • 0035883063 scopus 로고    scopus 로고
    • Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma
    • Lossos IS, Jones CD, Warnke R, Natkunam Y, Kaizer H, Zehnder JL, et al. Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma. Blood 2001;98:945-951
    • (2001) Blood , vol.98 , pp. 945-951
    • Lossos, I.S.1    Jones, C.D.2    Warnke, R.3    Natkunam, Y.4    Kaizer, H.5    Zehnder, J.L.6
  • 54
    • 27244445488 scopus 로고    scopus 로고
    • State-of-the-art therapeutics: Diffuse large B-cell lymphoma
    • Coiffier B. State-of-the-art therapeutics: diffuse large B-cell lymphoma. J Clin Oncol 2005;23:6387- 93.
    • (2005) J Clin Oncol , vol.23 , pp. 6387-6393
    • Coiffier, B.1
  • 55
    • 38549147027 scopus 로고    scopus 로고
    • German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ Bcell lymphomas: A randomised controlled trial (RICOVER-60)
    • Pfreundschuh M, Schubert J, Ziepert M, Schmits R, Mohren M, Lengfelder E, et al. German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ Bcell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 2008;9:105-116
    • (2008) Lancet Oncol , vol.9 , pp. 105-116
    • Pfreundschuh, M.1    Schubert, J.2    Ziepert, M.3    Schmits, R.4    Mohren, M.5    Lengfelder, E.6
  • 56
    • 34249673388 scopus 로고    scopus 로고
    • Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy
    • DOI 10.1182/blood-2006-09-047068
    • Nyman H, Adde M, Karjalainen- Lindsberg ML, Taskinen M, Berglund M, Amini RM, et al. Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy. Blood 2007;109:4930-4935 (Pubitemid 46827791)
    • (2007) Blood , vol.109 , Issue.11 , pp. 4930-4935
    • Nyman, H.1    Adde, M.2    Karjalainen-Lindsberg, M.-L.3    Taskinen, M.4    Berglund, M.5    Amini, R.-M.6    Blomqvist, C.7    Enblad, G.8    Leppa, S.9
  • 58
    • 0037698992 scopus 로고    scopus 로고
    • Rituximab plus CHOP (R-CHOP) overcomes bcl-2--associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL)
    • Mounier N, Briere J, Gisselbrecht C, Emile JF, Lederlin P, Sebban C, et al. Rituximab plus CHOP (R-CHOP) overcomes bcl-2--associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL). Blood 2003;101:4279-4284
    • (2003) Blood , vol.101 , pp. 4279-4284
    • Mounier, N.1    Briere, J.2    Gisselbrecht, C.3    Emile, J.F.4    Lederlin, P.5    Sebban, C.6


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