Immune response of mice transgenic for human histocompatibility leukocyte antigen-dr to human thyrotropin receptor-extracellular domain

Thyroid

Volumn 19, Issue 11, 2009, Pages 1271-1280

  Inaba, Hidefumi ^a   Pan, Deshun ^b   Shin, Young Ha ^b   Martin, William ^c   Buchman, George ^d   De Groot, Leslie J ^a,b  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c EpiVax Inc   (United States)

^d Chesapeake PERL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ENZYME; EPITOPE; HLA DR ANTIGEN; HLA DR2 ANTIGEN; HLA DR3 ANTIGEN; LEUKOCYTE ANTIGEN; PEPTIDE; PROTEIN; RECOMBINANT PROTEIN; RECOMBINANT THYROTROPIN RECEPTOR ECD PROTEIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BINDING ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FEMALE; GENE SEQUENCE; GENETIC IMMUNIZATION; GENETIC REGULATION; GENOMICS; GRAVES DISEASE; HISTOLOGY; HYPERTHYROIDISM; IMMUNE RESPONSE; IMMUNITY; MOUSE; NONHUMAN; PREVENTIVE HEALTH SERVICE; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; THYROID GLAND; THYROXINE BLOOD LEVEL; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIBODIES; B-LYMPHOCYTES; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; HLA-DR2 ANTIGEN; HLA-DR3 ANTIGEN; HUMANS; IMMUNIZATION; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, THYROTROPIN; STAINING AND LABELING; T-LYMPHOCYTES; THYROID GLAND;

EID: 70449362075     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2008.0349     Document Type: Article

References (24)

1. De Groot LJ, Quintans J 1989 The causes of autoimmune thyroid disease. Endocr Rev 10:537-562.
2. Kyewski B, Klein L 2006 A central role for central tolerance. Annu Rev Immunol 24:571-606.
3. Blancou P, Mallone R, Martinuzzi E, Sévère S, Pogu S, Novelli G, Bruno G, Charbonnel B, Dolz M, Chaillous L, Van Endert P, Bach JM 2007 Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J Immunol 178:7458-7466.
4. Yang H, Goluszko E, David C, Okita DK, Conti-Fine B, Chan TS, Poussin MA, Christadoss P 2002 Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors inHLAtransgenic mice. J Clin Investig 109:1111-1120.
5. Couet J, Sar S, Jolivet A, Hai MT, Milgrom E, Misrahi M 1996 Shedding of human thyrotropin receptor ectodomain. Involvement of a matrix metalloprotease. J Biol Chem 271: 4545-4552. (Pubitemid 26070565)
6. Soliman M, Kaplan E, Straus F, Fisfalen ME, Hidaka Y, Guimaraes V, DeGroot LJ 1995 Graves' disease in severe combined immunodeficient mice. J Clin Endocrinol Metab 80:2848-2855.
7. Hidaka Y, Guimaraes V, Soliman M, Yanagawa T, Okamoto Y, Quintans J, DeGroot LJ 1995 Production of thyroid-stimulating antibodies in mice by immunization with T-cell epitopes of human thyrotropin receptor. Endocrinology 136:1642-1647.
8. Jacobson EM, Tomer Y 2007 The genetic basis of thyroid autoimmunity. Thyroid 10:949-961.
9. Shimojo N, Kohno Y, Yamaguchi K, Kikuoka S, Hoshioka A, Niimi H, Hirai A, Tamura Y, Saito Y, Kohn LD, Tahara K 1996 Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci USA 93:11074-11079.
10. Costagliola S, Many MC, Denef JF, Pohlenz J, Refetoff S, Vassart G 2000 Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J Clin Investig 105:803-811.
11. Nagayama Y, Kita-Furuyama M, Ando T, Nakao K, Mizuguchi H, Hayakawa T, Eguchi K, Niwa M 2002 A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol 168:2789-2794.
12. Chen CR, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM 2003 The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim. J Clin Investig 111:1897-1904.
13. Kaneda T, Honda A, Hakozaki A, Fuse T, Muto A, Yoshida T 2007 An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB=c mice. Endocrinology 148: 2335-2344.
14. McLachlan SM, Nagayama Y, Rapoport B 2005 Insight into Graves' hyperthyroidism from animal models. Endocr Rev 26:800-832.
15. Nagayama Y, McLachlan SM, Rapoport B, Niwa M 2003 A major role for non-major histocompatibility complex genes but not for microorganisms in a novel murine model of Graves' hyperthyroidism. Thyroid 13:233-238.
16. Pichurin P, Chen CR, Pichurina O, David C, Rapoport B, McLachlan SM 2003 Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. Thyroid 13:911-917.
17. Kong YC, Flynn JC, Banga JP, David CS 2007 Application of HLA class II transgenic mice to study autoimmune regulation. Thyroid 17:995-1003.
18. Inaba H, Martin W, De Groot AS, Qin S, De Groot LJ 2006 Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves' disease. J Clin Endocrinol Metab 91:2286-2294.
19. Sawai Y, DeGroot LJ 2000 Binding of human thyrotropin receptor peptides to a Graves' disease-predisposing human leukocyte antigen class II molecule. J Clin Endocrinol Metab 85:1176-1179.
20. Okamoto Y, Hayashi Y, DeGroot LJ 1995 Expression of human thyrotropin receptor by recombinant adenovirus. Thyroid 5:51-53.
21. Soliman M, Kaplan E, Fisfalen ME, Okamoto Y, DeGroot LJ 1995 T-cell reactivity to recombinant human thyrotropin receptor extracellular domain and thyroglobulin in patients with autoimmune and nonautoimmune thyroid diseases. J Clin Endocrinol Metab 80:206-213.
22. Sawai Y, DeGroot LJ 2000 Binding of human thyrotropin receptor peptides to a Graves' disease-predisposing human leukocyte antigen class II molecule. J Clin Endocrinol Metab 85:1176-1179.
23. Arima T, Shimojo N, Yamaguchi K, Tomiita M, Kohn LD, Kohno Y 2008 Enhancement of experimental Graves' disease by intranasal administration of a T cell epitope of the thyrotropin receptor. Clin Immunol 127:7-13.
24. Pichurin P, Pham N, David CS, Rapoport B, McLachlan SM 2006 HLA-DR3 transgenic mice immunized with adenovirus encoding the thyrotropin receptor: T cell epitopes and functional analysis of the CD40 Graves' polymorphism. Thyroid 16:1221-1227.