A G-quartet oligonucleotide blocks glycoprotein Ib-mediated platelet adhesion and aggregation under flow conditions

Thrombosis and Haemostasis

Volumn 102, Issue 3, 2009, Pages 529-537

  Zhou, Zhou ^a   Bernardo, Aubrey ^a   Zhu, Qiqing ^a   Guan, Yongli ^a   Sun, Wensheng ^a   Lopez, Jose A ^b   Jing, Naijie ^a   Dong, Jing Fei ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b PUGET SOUND BLOOD CENTER   (United States)

Author keywords

G quartet; GP Ib; Oligonucleotide; Platelet; Shear stress; Von Willebrand factor

Indexed keywords

ADENOSINE DIPHOSPHATE; BOTROCETIN; COLLAGEN; GLYCOPROTEIN IB ALPHA; OLIGONUCLEOTIDE; RISTOCETIN; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; VON WILLEBRAND FACTOR;

ARTICLE; BETA SHEET; COMPUTER SIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; SHEAR STRESS; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GLYCOPROTEINS; HUMANS; MOLECULAR CONFORMATION; OLIGONUCLEOTIDES; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRESS, MECHANICAL; VON WILLEBRAND FACTOR;

EID: 70449360725     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-01-0052     Document Type: Article

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