Characterization of a novel TPMT mutation associated with azathioprine-induced myelosuppression: Letter to the Editors

British Journal of Clinical Pharmacology

Volumn 68, Issue 5, 2009, Pages 770-772

  De Beaumais, Tiphaine Adam ^a   Fakhoury, May ^a   Pigneur, Benedicte ^b   Viola, Sheila ^b   Medard, Yves ^a   Broly, Franck ^c   Jacqz Aigrain, Evelyne ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b ARMAND TROUSSEAU HOSPITAL   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CORTISONE; INFLIXIMAB; MESALAZINE; THIOPURINE METHYLTRANSFERASE;

ABDOMINAL PAIN; BONE MARROW SUPPRESSION; CASE REPORT; CHILD; ENTERITIS; FEMALE; FEVER; GENE; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HUMAN; IRAN; LETTER; PANCYTOPENIA; PRIORITY JOURNAL; RECTUM HEMORRHAGE; TPMT GENE; VOMITING;

ANTIMETABOLITES; AZATHIOPRINE; CHILD; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; METHYLTRANSFERASES; MUTATION; PEDIGREE; POLYMORPHISM, GENETIC; TREATMENT OUTCOME;

EID: 70449341650     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03439.x     Document Type: Letter

References (4)

1. Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Théorêt Y, Seidman EG. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000 118 : 705 713.
2. Garat A, Cauffiez C, Renault N, Lo-Guidice JM, Allorge D, Chevalier D, Houdret N, Chavatte P, Loriot MA, Gala JL, Broly F. Characterisation of novel defective thiopurine S-methyltransferase allelic variants. Biochem Pharmacol 2008 76 : 404 415.
3. Colombel JF, Ferrari N, Debuysere H, Marteau P, Gendre JP, Bonaz B, Soulé JC, Modigliani R, Touze Y, Catala P, Libersa C, Broly F. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000 118 : 1025 1030.
4. Cheok MH, Evans WE. Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy. Nat Rev Cancer 2006 6 : 117 129.