Molecular imaging through the blood-brain barrier: Safety assessment and parameter dependence

Proceedings - 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009

Volumn , Issue , 2009, Pages 771-774

  Konofagou, Elisa E ^a   Choia, James ^a   Lee, Ann ^a   Baseri, Babak ^a  

^a Fu Foundation School of Engineering and Applied Science   (United States)

Author keywords

Keywords component; Harmonic Motion imaging; loss modulus; hear modulus; storage modulus.

Indexed keywords

BLOOD-BRAIN BARRIER; BRAIN REGIONS; COMPLIANT VESSELS; DIFFERENT SIZES; DUTY CYCLES; FOCUSED ULTRASOUND; IN-VIVO; INTRAVENOUS INJECTIONS; KEYWORDS-COMPONENT HARMONIC MOTION IMAGING LOSS MODULUS HEAR MODULUS STORAGE MODULUS.; MICRO-BUBBLE; MICROBUBBLES; MOLECULAR IMAGING; NEURODEGENERATIVE DISEASE; PARAMETER DEPENDENCE; PERMEABILITY CHANGE; SAFETY ASSESSMENTS; TUMOR MODELS; ULTRASOUND PARAMETERS; VASCULAR EFFECTS;

ACOUSTIC WAVES; BLOOD; CAPILLARITY; DRUG DELIVERY; ELASTIC MODULI; MECHANICAL PERMEABILITY; ULTRASONICS;

ULTRASONIC IMAGING;

EID: 70449331462     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ISBI.2009.5193163     Document Type: Conference Paper

References (14)

1. Pangalos MN et al. (2007) Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nat Rev Drug Discov 6(7):521-532.
2. Van Dam D & De Deyn PP (2006) Drug discovery in dementia: the role of rodent models. Nat Rev Drug Discov 5(11):956-970.
3. Kinoshita et al. (2006) Noninvasive localized delivery of Herceptin to the mouse brain by MRIguided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A 103(31):11719-11723.
4. Treat LH, et al. (2007) Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. International journal of cancer 121(4):901-907.
5. Sheikov N, et al. (2006) Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. Ultrasound Med Biol 32(9):1399-1409.
6. Choi JJ, et al. (2007) Spatio-temporal analysis of molecular delivery through the blood-brain barrier using focused ultrasound. Phys Med Biol 52(18):5509-5530.
7. Choi JJ, et al.(2007) Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. Ultrasound Med Biol 33(1):95-104.
8. Choi JJ, et al. (2008) Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using pulsed Focused Ultrasound. Ultrasonic Imaging (iin press).
9. Konofagou E.E. et al., Biomedical Applications of vibration and Acoustics in therapy, Bioeffects and modelling, Eds: A.Al-Jumaily and M. Fatemi, ASME Press, Chapter 3, pp. 63-80, 2008.
10. Jiang et al. (2005) Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI. Journal of Cerebral Blood Flow and Metabolism. pp. 583-592.
11. Ding et al (2006)., J. of Brain Res.,195-203.
12. Feshitan J. A.et al. (2008), Journal of Colloid and Interf Sci, 2008 (n press).
13. Sassaroli and Hynynen (2005), Resonance frequency of microbubbles in small blood vessels: a numerical study, Phys. Med. Biol., 5293-5305.
14. Zheng et al. (2007), Ultrasound-driven microbubble oscillation and translation within small phantom vessels.Ultras. Med. Biol.,1140-48.