Immunosuppressive effect of ethanol extract of Artemisia annua on specific antibody and cellular responses of mice against ovalbumin

Immunopharmacology and Immunotoxicology

Volumn 31, Issue 4, 2009, Pages 625-630

  Zhang, Yan Xiang ^a,b   Sun, Hong Xiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Antibody; Artemisia annua; Immunosuppressive; OVA; Splenocyte proliferation

Indexed keywords

ALCOHOL; ARTEMISIA ANNUA EXTRACT; CONCANAVALIN A; CYCLOSPORIN A; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; LIPOPOLYSACCHARIDE; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMORAL IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ARTEMISIA ANNUA; CELL PROLIFERATION; CELLS, CULTURED; DRUGS, CHINESE HERBAL; ETHANOL; FEMALE; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED ICR; OVALBUMIN; PLANT COMPONENTS, AERIAL; SPLEEN;

ARTEMISIA ANNUA; MUS;

EID: 70449132576     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923970902932954     Document Type: Article

References (28)

1. Mueller MS, Karhagomba IB, Hirt HM,Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: Agricultural, chemical andclinical aspects. J. Ethnopharmacol. (2000), 73, 487-493.
2. Wallart TE, Pras N, Quax WJ. Isolation and identification of dihydroartemisinic acid hydroperoxide from artemisia annua: A novel biosynthetic precursor of artemisinin. J. Nat. Prod. (1999), 62, 1160-1162. (Pubitemid 29418347)
3. Brown GD, Liang GY, Sy LK. Terpenoids from the seeds of Artemisia annua. Phytochemistry (2003), 64, 303-323.
4. Stermitz FR, Scriven LN, Tegos G, Lewis K. Two flavonols from Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Med. (2002), 68, 1140-1141.
5. Perazzo FF, Carvalho JC, Carvalho JE, Rehder VL. Central properties of the essential oil and the crude ethanol extract from aerial parts of Artemisia annua L. Pharmacol. Res. (2003), 48, 497-502.
6. Kim JT, Park JY, Seo HS, Oh HG, Noh JW, Kim JH, Kim DY, Youn HJ. In vitro antiprotozoal effects of artemisinin on Neospora caninum. Vet. Parasitol. (2002), 103, 53-63.
7. Huang L, Liu JF, Liu LX, Li DF, Zhang Y, Niu HZ, Song HY, Zhang CY. Antipyretic and anti-inflammatory effects of Artemisia annua L. China J. Chin. Mater. Med. (1993), 18, 44-48, 63-64.
8. Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR. The anti-malarial artesunate is also active against cancer. Int. J. Oncol. (2001), 18, 767-773.
9. Dias PC, Foglio MA, Possenti A, Nogueira DC, de Carvalho JE. Antiulcerogenic activity of crude ethanol extract and some fractions obtained from aerial parts of Artemisia annua L. Phytother. Res. (2001), 15, 670-675.
10. Tan Y, Zhao Y, Lin Q, Xie G, Yang P, Yin X. Experimental study on antiendotoxin effect of extracts from Artemisia annua L. China J. Chin. Mater. Med. (1999), 24, 166-171.
11. Liu CH, Zou WX, Lu H, Tan RX. Antifungal activity of Artemisia annua endophyte cultures against phytopathogenic fungi. J. Biotechnol. (2001), 88, 277-282
12. Zhao HF, Zhong JX, Peng SQ, Liu SC. Study of sweet wormwood compound on SLE in mice. Chin. J. Inform. TCM. (1998), 5 (8), 18-19.
13. Qi Y, Hu H, Sun MJ, Zhou YH, Sui Y, Qi M. Study of sweet wormwood compound on Pharmacodynamics of prevenling RA. World J Integr Tradit. West Med. (2006), 1 (2), 94-97.
14. Noori S, Naderi GA, Hassan ZM, Habibi Z, Bathaie SZ, Hashemi SMM. Immunosuppressive activity of a molecule isolated from Artemisia annua on DTH responses compared with cyclosporin A. Int. Immunopharmacol. (2004), 4, 1301-1306.
15. Yang ZS, Zhou WL, Sui Y, Wang JX, Wu JM, Zhou Y, Zhang Y, He PL, Han JY, Tang W, Li Y, Zuo JP. Synthesis and immunosuppressive activity of new artemisinin derivatives. 1. [12(β or α)-dihydroartemisininoxy] phen(ox)yl aliphatic acids and esters. J. Med. Chem. (2005), 48, 4608-4617
16. Tawfik AF, Bishop SJ, Ayalp A, el-Feraly FS. Effects of artemisinin, dihydroartemisinin and arteether on immune responses of normal mice. Int. J. Immunopharmacol. (1990), 12 (4), 385-389.
17. Cuzzocrea S, Saadat F, Di Paola, R,Mirshafiey A. Artemether: A new therapeutic strategy in experimental rheumatoid arthritis. Immunopharmacol. Immunotoxicol. (2005), 27, 615-630.
18. Li WD, Dong YJ, Tu YY, Lin ZB. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF--1250.
19. Mirshafiey A, Saadat F, Attar M, Di Paola R, Sedaghat R, Cuzzocrea S. Design of a new line in treatment of experimental rheumatoid arthritis by artesunate. Immunopharmacol. Immunotoxicol. (2006), 28, 397-410.
20. Wang JX, Tang W, Shi LP, Wan J, Zhou R, Ni J, Fu YF, Yang YF, Li Y, Zuo JP. Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation. Br. J. Pharmacol. (2007), 150 (5), 652-661.
21. Wang ZJ, Qiu J, Guo TB, Liu AL, Wang Y, Li Y, Zhang ZJW. Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis. J. Immunol. (2007), 179, 5958-5965.
22. Wang JX, Tang W, Zhou R, Wan J, Shi LP, Zhang Y, Yang YF, Li Y, Zuo JP. The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses. Br. J. Pharmacol. (2008), 153 (6), 1303-1310.
23. Li JS, Jiang WZ. Determination of artemisinin in artemisia annuna by RP-HPLC. Herald Med. (2005), 24, 1053-1054.
24. Sun HX, Qin F, Pan YJ. In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice. J. Ethnopharmacol. (2005),101, 31-36 (Pubitemid 41265597)
25. Engel LW, Strauss SE. Development of therapeutics: Opportunities within complementary and alternative medicine. Nat. Rev. Drug Discov. (2002), 1, 229-237.
26. Cobbold SP. New trends in immunosuppression. Int. Immunopharm. (2005), 5, 1-5.
27. Gutierrez-Dalmau A, Campistol JM. (2007) Immunosuppressive therapy and malignancy in organ transplant recipients: A systematic review. Drugs 67, 1167-1198
28. Qin F, Sun HX. New advances in the immunosuppressant effect of traditional Chinese medicines. J. Tradit. Chin. Vet. Med. (2004), (2), 36-40.