Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma

Human Pathology

Volumn 40, Issue 12, 2009, Pages 1679-1685

  Kalinski, Thomas ^a   Röpke, Albrecht ^b   Sel, Saadettin ^c   Kouznetsova, Irina ^a   Röpke, Martin ^a   Roessner, Albert ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Cartilage tissue; Chondrosarcoma; Ephrin A5; Hypoxia

Indexed keywords

EPHRIN A5;

ARTICLE; ARTICULAR CARTILAGE; CANCER GRADING; CARCINOGENESIS; CELL ADHESION; CHONDROSARCOMA; CONTROLLED STUDY; DOWN REGULATION; GENE MUTATION; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PROTEIN EXPRESSION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; WESTERN BLOTTING;

BLOTTING, WESTERN; BONE NEOPLASMS; CARTILAGE; CELL HYPOXIA; CHONDROSARCOMA; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; DOWN-REGULATION; EPHRIN-A5; HUMANS; IMMUNOHISTOCHEMISTRY; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 70449123803     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.03.024     Document Type: Article

References (22)

1. Martínez A., and Soriano E. Functions of ephrin/Eph interactions in the development of the nervous system: emphasis on the hippocampal system. Brain Res Brain Res Rev 49 (2005) 211-226
2. Zhang J., and Hughes S. Role of the ephrin and Eph receptor tyrosine kinase families in angiogenesis and development of the cardiovascular system. J Pathol 208 (2006) 453-461
3. Davy A., and Soriano P. Ephrin signaling in vivo: look both ways. Dev Dyn 232 (2005) 1-10
4. Himanen J.P., Chumley M.J., Lackmann M., et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci 7 (2004) 501-509
5. Davy A., Gale N.W., Murray E.W., et al. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev 13 (1999) 3125-3135
6. Davy A., and Robbins S.M. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner. EMBO J 19 (2000) 5396-5405
7. Huai J., and Drescher U. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. J Biol Chem 276 (2001) 6689-6694
8. Murai K.K., and Pasquale E.B. "Eph"ective signaling: forward, reverse and crosstalk. J Cell Sci 116 Pt 14 (2003) 2823-2832
9. Surawska H., Ma P.C., and Salgia R. The role of ephrins and Eph receptors in cancer. Cytokine Growth Factor Rev 15 (2004) 419-433
10. Héroult M., Schaffner F., and Augustin H.G. Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression. Exp Cell Res 312 (2006) 642-650
11. Kalinski T., Krueger S., Pelz A.F., et al. Establishment and characterization of the permanent human cell line C3842 derived from a secondary chondrosarcoma in Ollier's disease. Virchows Arch 446 (2005) 287-299
12. Kalinski T., Krueger S., Sel S., Werner K., Ropke M., and Roessner A. Differential expression of VEGF-A and angiopoietins in cartilage tumors and regulation by interleukin-1beta. Cancer 106 (2006) 2028-2038
13. Krueger S., Kalinski T., Hundertmark T., et al. Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. J Pathol 207 (2005) 32-42
14. Röpke A., Buhtz P., Böhm M., et al. Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. Oncogene 24 (2005) 6667-6675
15. Fox B.P., and Kandpal R.P. Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem Biophys Res Commun 318 (2004) 882-892
16. Herath N.I., Spanevello M.D., Sabesan S., et al. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. BMC Cancer 6 (2006) 144
17. Varelias A., Koblar S.A., Cowled P.A., Carter C.D., and Clayer M. Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. Cancer 95 (2002) 862-869
18. Shi H., Guo J., Duff D.J., et al. Discovery of novel epigenetic markers in non-Hodgkin's lymphoma. Carcinogenesis 28 (2007) 60-70
19. Kuang S.Q., Tong W.G., Yang H., et al. Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia. Leukemia 22 (2008) 1529-1538
20. Vihanto M.M., Plock J., Erni D., Frey B.M., Frey F.J., and Huynh-Do U. Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin. FASEB J 19 (2005) 1689-1691
21. Campbell T.N., Attwell S., Arcellana-Panlilio M., and Robbins S.M. Ephrin A5 expression promotes invasion and transformation of murine fibroblasts. Biochem Biophys Res Commun 350 (2006) 623-628
22. Campbell T.N., Davy A., Liu Y., Arcellana-Panlilio M., and Robbins S.M. Distinct membrane compartmentalization and signaling of ephrin-A5 and ephrin-B1. Biochem Biophys Res Commun 375 (2008) 362-366