In vitro antileishmanial activity of hydroalcoholic extract, fractions, and compounds isolated from leaves of piper ovatum vahl against Leishmania amazonensis

Acta Protozoologica

Volumn 48, Issue 1, 2009, Pages 73-81

  Rodrigues Silva, Daniel ^a   Nakamura, Celso Vataru ^a   Dias Filho, Benedito Prado ^a   Ueda Nakamura, Tânia ^a   Cortez, Diógenes Aparício Garcia ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Antiprotozoan activity; Leishmania amazonensis; Piper ovatum; Ultrastructure alterations

Indexed keywords

LEISHMANIA AMAZONENSIS; PIPERACEAE; PROTOZOA;

EID: 70449112781     PISSN: 00651583     EISSN: 16890027     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Brenzan M. A., Ferreira I. C. P., Lonardoni M. V. C., Honda P. A., Rodriguez-Filho E., Nakamura C. V., Dias-Filho B. P., Ueda-Nakamura T., Cortez D. A. G. (2008) Activity of extracts and coumarins from leaves of Calophyllum brasiliense Camb. on Leishmania braziliensis. Pharm. Biol. 46: 1-7
2. Brenzan M. A., Nakamura C. V., Dias-Filho B. P., Ueda-Nakamura T., Young M. C. M., Cortez D. A. G. (2007) Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis. Parasitol. Res. 101: 715-722
3. Correa M. P. (1984) Dicionario das Plantas Uteis do Brasil e das Exoticas Cultivadas, vol. 1. Instituto Brasileiro de Desenvolvimento Florestal, Rio de Janeiro
4. Croft S. L., Barrett M. P., Urbina J. A. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends Parasitol. 21: 508-512
5. Cunico M. M., Dias J. G., Miguel M. D., Miguel O. G., Auer C. G., Cocco L. C., Lopes A. R., Yamamoto C. I., Monache F. D. (2006) Potencial antimicrobiano e alelopático das amidas isoladas do extrato das raízes de Ottonia martiana Miq. Quim. Nova. 29: 746-749
6. Delorenzi J. C., Attias M., Gattass C. R., Andrade M., Rezende C., Pinto A. C., Henriques A. T., Bou-Habib D. C., Saraiva M. B. (2001) Antileishmanial Activity of an Indole Alkaloid from Peschiera australis Antim. Agents Chemoth. 45: 1349-1354.
7. Estevez Y., Castillo D., Pisango M. T., Arevalo J., Rojas R., Alban J., Deharo E., Bourdy G., Sauvain M. (2007) Evaluation of the leishmanicidal activity of plants used by Peruvian Chayahuita ethnic group J. Ethnopharmacol. 114: 254-259
8. Handman E. (2001) Leishmaniasis: current status of vaccine development, Clin. Microbiol. Rev. 14: 229-243
9. Kapil A. (1993) Piperine: a potent inhibitor of Leishmania donovani promastigotes in vitro. Planta Med. 59: 474
10. López A., Ming D. S., Towers G. H. N. (2002) Antifungical activity of benzoic acid derivatives from Piper lanceaefolium. J. Nat. Prod. 65: 62-64
11. Lorente S. O., Rodriggues J. C. F., Jiménez C. J., Joyce-Menekse M., Rodrigues C., Croft S. L., Yardley V., Luca-Frandley K., Ruiz-Pérez L. M., Urbina J., Souza W., Pacanowska D. G., Gilbert I. H. (2004) Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis. Antim. Agents Chemother. 48: 2937-2950
12. Luize P. S., Tiuman T. S., Morello L. G., Maza P. K., Ueda-Naka-mura T., Dias-Filho B. P., Cortez D. A. G., Mello J. C. P., Naka-mura C. V. (2005) Effects of medicinal plant extracts on growth of Leishmania (L.) amazonensis and Trypanosoma cruzi. Rev. Bras. Ci. Farma. 41: 85-94
13. Macferren M. A., Rodriguez E. (1998) Piscicidal properties of piperovatine from Piper piscatorum. J. Ethnopharmacol. 60: 183-187
14. McFerren M. A., Cordova D., Rodriguez E., Rauh J. J., (2002) In vitro neuropharmacological evaluation of piperovatine, an isobutylamide from Piper piscatorum (Piperaceae). J. Ethnopharmacol. 83: 201-207
15. Makapugay H., Soejarto D. D., Kinghorn A. D., Bordas E. (1983) Piperovatine, the tongue-numbing principle of Ottonia frutencens. J. Ethnopharmacol. 7: 235-238
16. Martins R. C., Lago J. H., Albuquerque S., Kato M. J. (2003) Trypanocidal tetrahydrofuran lignans from infl orescences of Piper solmsianun. Phytochemistry 64: 667-670
17. Murray H. W. (2001) Clinical and experimental advances in treatment of visceral leishmaniasis. Antim. Agent. Chem. 45: 2185-2197
18. Nakamura C. V., Santos A. O., Vendrametto M. C., Luize P. S., Dias-Filho B. P., Cortez D. A. G., Nakamura T. U. (2006) Atividade antileishmania do extrato hidroalcoólico e de frações obtidas de folhas de Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck. Rev. Bras. Farmacogn. 16: 61-66
19. Obando D., Widmer F., Wright L. C., Sorrell T. C., Jolliffe K. A. (2007) Synthesis, antifungal and antimicrobial activity of alkyl-phospholipids. Bioorg. Med. Chem. 15: 5158-5165
20. Park S. B., Lee S. E., Shin S. C., Park J. D., Ahn Y. J. (2002) Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species. J. Agric. Food Chem. 50: 1866-1870
21. Parmar V. S., Jain S. C., Bisht K. S., Jain R., Taneja P., Amitabh J. H. A., Tyagi O. D., Prasad A. K., Wengel J., Olsen C. E., Boll P. M. (1977) Phytochemistry of the genus Piper. Phytochemistry 46: 591-673
22. Quijano-Abril M. A., Callejas-Posada R., Miranda-Esquivel D. R., (2006) Areas of endemism and distribution patterns for neotropical Piper species (Piperaceae). J. Biogeogr. 33: 1266-1278
23. Rodrigues C. O., Catisti R., Uymura S. A., Vercesi A. E., Lira R., Rodrigues C., Urbina J. Á, Docampo R. (2001) The sterol composition of Trypanosoma cruzi changes after growth in different culture media and results in the different sensitivity to digitonin permeabilization. J. Eukaryot. Microbiol. 48: 588-594
24. Rodrigues-Silva D., Baroni S., Svidzinski A. E., Bersani-Amado C. A., Cortez D. A. G. (2008) Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae). J. Ethnopharmacol. 116: 569-573
25. Torres-Santos E. C., Moreira D. L., Kaplan M. A. C., Meirelles M. N., Rossi-Bergmann B. (1999) Selective Effect of 2',6'-Dihydroxy-4'-Methoxychalcone Isolated from Piper aduncum on Leishmania amazonensis. Antim. Agent. Chem. 43: 1234-1241
26. Ueda-Nakamura T., Attias M., Souza W. (2001) Megasome biogenesis in Leishmania amazonensis: a morphometric and cytochemical study. Parasitol. Res. 87: 89-97
27. Ueda-Nakamura T., Mendonça-Filho R. R., Morgado-Diaz J.A., Maza P. K., Dias Filho B. P., Cortez, D A. G., Alvino D. S., Rosa M. S., Lopes A. H. C. S., Alvino C. S., Nakamura C. V. (2006) Antileshmanial activity of eugenol-rich essential oil from Ocimum gratissimum. Parasitol. Int. 55: 99-105
28. Vannier-Santos M.A., Urbina J.A., Martiny A., Neves A., Souza W. (1995) Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania. J. Eukaryot. Microb. 42: 337-346
29. Vannier-Santos M. A., Urbina J. A., Martiny A., Neves A., Souza W. (1995) Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania. J. Eukaryot. Microb. 42: 337-346
30. Wanke S., Samain, M.S., Vanderschaeve L., Mathieu G., Goetghe-beur P., Neinhuis C., (2006) Phylogeny of the genus Peperomia (Piperaceae) inferred from the trnK/matK region (cpDNA). Plant Biol. 8: 93-102
31. World Health Organ. (2001) Leishmaniasis: the disease and its impact. http://www.who.int/emc/diseases/leish/leisdis1.html. Accessed 12 December 2006
32. Wright C. W., Phillipson J. D. (1990) Natural products and the development of selective antiprotozoal drugs. Phtytother. Res. 4: 127-139
33. Wu S., Sun C., Pei S., Lu Y., Pan Y., (2004) Preparative isolation and purification of amides from the fruits of Piper longum L. by up-right counter-current chromatography and reversed-phase liquid chromatography. J. Chromatog. A 1040: 193-204
34. Zacchino S., Rodrígues G., Pezzenati G., Orellana G. (1997) In vitro evaluation of antifungal properties of 8.O.4'-neolignans. J. Nat. Prod. 60: 659-662