Long-lasting smooth-muscle relaxation by a novel PACAP analogue in human bronchi

Regulatory Peptides

Volumn 123, Issue 1-3 SPEC. ISS., 2004, Pages 161-165

  Yoshihara, Shigemi ^a   Yamada, Yumi ^a   Abe, Toshio ^a   Kashimoto, Kazuhisa ^b   Lindén, Anders ^c   Arisaka, Osamu ^a  

^a DOKKYO UNIVERSITY   (Japan)

^b Pharm Group   (Japan)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Airway smooth muscle relaxation; Bronchodilation; Human bronchi; PACAP1 27; PACAP1 27 analogue

Indexed keywords

CAPTOPRIL; CARBACHOL; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE GLYCYLLYSYLARGINYLAMIDE[15,20,21 ARGININE 17 LEUCINE]; PEPTIDASE; PHOSPHORAMIDON; SALBUTAMOL; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUSCLE; CONCENTRATION RESPONSE; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION;

AMINO ACID SEQUENCE; BRONCHI; HUMANS; MOLECULAR SEQUENCE DATA; MUSCLE RELAXATION; MUSCLE, SMOOTH; NERVE GROWTH FACTORS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE;

EID: 7044270832     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2004.04.023     Document Type: Article

References (19)

1. Arimura A. Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul. Pept. 37:1992;287-303
2. Cardell L-O., Uddman R., Luts A., Sundler F. Pituitary adenylate-cyclase activating peptide (PACAP) in guinea pig lung: distribution and dilatory effects. Regul. Pept. 36:1991;379-390
3. Luts A., Uddman R., Alm P., Basterra J., Sundler F. Peptide-containing nerve fibers in human airways: distribution and coexistence pattern. Int. Arch. Allergy Immunol. 101:1993;52-60
4. +-ATPase in airway smooth muscle relaxation by vasoactive intestinal peptide and pituitary adenylate cyclase activating peptide. Res. Commun. Chem. Pathol. Pharmacol. 79:1993;11-22
5. Lindén A., Cardell L.O., Yoshihara S., Stjarne P., Nadel J.A. PACAP1-38 as an inhaled bronchodilator in guinea pigs in vivo. Peptides. 19:1998;93-98
6. Lindén A., Yoshihara S., Chan B., Nadel J.A. Inhibition of bronchoconstriction by pituitary adenylate-cyclase activating peptide (PACAP 1-27) in guinea-pigs in vivo. Br. J. Pharmacol. 115:1995;913-916
7. Yoshihara S., Lindén A., Kashimoto K., Nagano Y., Ichimura T., Nadel J.A. A novel PACAP 1-27 analogue causes sustained smooth muscle relaxation in guinea pig trachea. Ann. N. Y. Acad. Sci. 805:1996;536-542
8. Lindén A., Cardell L.O., Yoshihara S., Nadel J.A.. Bronchodilation by pituitary adenylate cyclase-activating peptide and related peptides. Eur. Respir. J. 14:1999;443-451
9. Yoshihara S., Lindén A., Kashimoto K., Nagano Y., Ichimura T., Nadel J.A. Long lasting smooth muscle relaxation by a novel PACAP analogue in guinea pig and primate airways in vitro. Br. J. Pharmacol. 121:1997;1730-1734
10. Okazawa A., Cui Z.H., Lotvall J., Yoshihara S., Skoogh B.E., Kashimoto K., et al. Effect of a novel PACAP1-27 analogue on muscarinic airway responsiveness in guinea-pigs in vivo. Eur. Respir. J. 12:1998;1062-1066
11. Ishizuka Y., Kashimoto K., Mochizuki T., Sato K., Ohshima K., Yanaihara N. Cardiovascular and respiratory actions of pituitary adenylate cyclase-activating polypeptides. Regul. Pept. 40:1992;29-39
12. Nandha K.A., Benito-Orfila M.A., Smith D.M., Ghatei M.A., Bloom S.R. Action of pituitary adenylate-cyclase-activating polypeptide and vasoactive intestinal polypeptide on the rat vascular system: effects on blood pressure and receptor binding. J. Endocrinol. 129:1991;69-73
13. Lindén A., Bergendal A., Ullman A., Skoogh B-E., Lofdahl C-G. Salmeterol, formoterol, and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism. Thorax. 48:1993;547-553
14. Barnes P., Dixon C.M. The effect of inhaled vasoactive intestinal polypeptide on bronchial reactivity to histamine in humans. Am. Rev. Respir. Dis. 130:1984;162-166
15. Morice A., Unwin R.J., Sever P.S. Vasoactive intestinal peptide causes bronchodilation and protects against histamine-induced bronchoconstriction in asthmatic subjects. Lancet. 2:1983;1225-1226
16. O'Donnell M., Garippa R.J., Rinaldi N., Selig W.M., Tocker J.E., Tannu S.A., et al. Ro-25-1553: a novel, long-acting vasoactive intestinal peptide agonist. Part II: effect on in vitro and in vivo models of pulmonary anaphylaxis. J. Pharmacol. Exp. Ther. 270:1994;1289-1294
17. Petkov V., Mosgoeller W., Ziesche R., Raderer M., Stiebellehher L., Vonbank K., et al. Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension. J. Clin. Invest. 111:2003;1339-1346
18. Kashimoto K., Nagano Y., Suitani Y., Hamanaka K., Mizumoto T., Tomizaki K., et al. Structure-activity relationship studies of PACAP 1-27 and VIP analogues. Ann. N. Y. Acad. Sci. 805:1996;505-510
19. 2 on carbachol-induced contraction of guinea pig tracheal smooth muscle in vitro. Biomed. Res. 19:1998;39-44