A novel PACAP 1-27 analogue causes sustained smooth muscle relaxation in guinea-pig trachea

Annals of the New York Academy of Sciences

Volumn 805, Issue , 1996, Pages 536-542

  Yoshihara, S ^a,b   Linden A ^a   Kashimoto, K ^c   Nagano, Y ^c   Ichimura, T ^b   Nadel, J A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

^c Itoham Central Research Institute   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAPTOPRIL; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE 27; PEPTIDASE; SALBUTAMOL; THEOPHYLLINE; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR;

ANIMAL TISSUE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; GUINEA PIG; MALE; NONHUMAN; PROTEIN MODIFICATION; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

EID: 0030465776     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb17515.x     Document Type: Conference Paper

References (12)

1. ARIMURA, A. 1992. Pituitary adenylate cyclase activating polypeptide (PACAP): Discovery and current status of research. Regul. Pept. 37: 287-303.
2. CARDELL, L.-O., R. UDDMAN, A. LUTS & F. SUNDLER. 1991. Pituitary adenylate-cyclase activating peptide (PACAP) in guinea pig lung: Distribution and dilatory effects. Regul. Pept. 36: 379-390.
3. +-ATPase in airway smooth muscle relaxation by vasoactive intestinal peptide and pituitary adenylate cyclase activating peptide. Res. Commun. Chem. Pathol. Pharmacol. 79: 11-22.
4. LINDÉN, A., S. YOSHIHARA, B. CHAN & J. A. NADEL. 1995. Inhibition of bronchoconstriction by pituitary adenylate-cyclase activating peptide (PACAP 1-27) in guinea-pigs in vivo. Br. J. Pharmacol. 115: 913-916.
5. LUTS, A., R. UDDMAN, P. ALM, J. BASTERRA & F. SUNDLER. 1993. Peptide-containing nerve fibers in human airways: Distribution and coexistence pattern. Int. Arch. Allergy Immunol. 101: 52-60.
6. ISHIZUKA, Y., K. KASHIMOTO, T. MOCHIZUKI, K. SATO, K. OHSHIMA & N. YANAIHARA. 1992. Cardiovascular and respiratory actions of pituitary adenylate cyclase-activating polypeptides. Regul. Pept. 40: 29-39.
7. NANDHA, K. A., M. A. BENITO-ORFILA, D. M. SMITH, M. A. GHATEI & S. R. BLOOM. 1991. Action of pituitary adenylate-cyclase-activating polypeptide and vasoactive intestinal polypeptide on the rat vascular system: Effects on blood pressure and receptor binding. J. Endocrinol. 129: 69-73.
8. YOSHIHARA, S., A. LINDÉN, K. KASHIMOTO, Y. NAGANO, T. ICHIMURA & J. A. NADEL. 1996. Long lasting smooth muscle relaxation by a novel PACAP analogue in guinea pig and primate airways in vitro. Br. J. Pharmacol. In press.
9. MORICE, A., R. J. UNWIN & P. S. SEVER. 1983. Vasoactive intestinal peptide causes bronchodilation and protects against histamin-induced bronchoconstriction in asthmatic subjects. Lancet 2: 1225-1226.
10. BARNES, P. & C. M. DIXON. 1984. The effect of inhaled vasoactive intestinal polypeptide on bronchial reactivity to histamine in humans. Am. Rev. Respir. Dis. 130: 162-166.
11. O'DONNELL, M., R. J. GARIPPA, N. RINALDI, W. M. SELIG, J. E. TOCKER, S. A. TANNU, M. A. WASSERMAN, A. WELTON & D. R. BOLIN. 1994. Ro-25-1553: A novel, long-acting vasoactive intestinal peptide agonist. Part II: Effect on in vitro and in vivo models of pulmonary anaphylaxis. J. Pharmacol. Exp. Ther. 270: 1289-1294.
12. KASHIMOTO, K., Y. NAGANO, Y. SUITANI, K. HAMANAKA, T. MIZUMOTO, K. TOMIZAKI, H. TAKAHATA, A. NAGAMOTO, A. OHATA, S. YOSHIHARA & T. ICHIMURA. 1996. Structure-activity relationship studies of PACAP-27 and VIP analogues. Ann. N.Y. Acad. Sci. This volume.