Up-regulatory impact of boron on vitamin D function - Does it reflect inhibition of 24-hydroxylase?

Medical Hypotheses

Volumn 63, Issue 6, 2004, Pages 1054-1056

  Miljkovic, Dusan ^a   Miljkovic, Natasha ^b   McCarty, Mark F ^a,c  

^a FutureCeuticals Inc   (Serbia)

^b UNIVERSITY OF NOVI SAD   (Serbia)

^c NutriGuard Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24,25 DIHYDROXYVITAMIN D; 25 HYDROXYVITAMIN D; BORON; ERGOCALCIFEROL; ESTRADIOL; HYDROXYL GROUP; MICROSOME ENZYME; OXYGENASE; STEROID;

ADULT; ARTICLE; CATABOLISM; CLINICAL ARTICLE; DIET; ENZYME ACTIVITY; ENZYME INHIBITION; HORMONAL THERAPY; HUMAN; HYDROXYLATION; MICROSOME; NUTRITION; PILOT STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; UPREGULATION; VITAMIN D DEFICIENCY; WINTER;

RODENTIA;

EID: 7044251871     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2003.12.053     Document Type: Article

References (21)

1. Hunt C.D., Herbel J.L. Boron affects energy metabolism in the streptozotocin-injected, vitamin D3-deprived rat. Magnes. Trace Elem. 10:1991;374-386
2. Hunt C.D., Herbel J.L. Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D3-deprived rat. Magnes. Trace Elem. 10:1991;387-408
3. Hegsted M., Keenan M.J., Siver F., Wozniak P. Effect of boron on vitamin D deficient rats. Biol. Trace Elem. Res. 28:1991;243-255
4. Hunt C.D., Herbel J.L., Idso J.P. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J. Bone Miner. Res. 9:1994;171-182
5. Hunt C.D. The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ. Health Perspect. 102(Suppl. 7):1994;35-43
6. Dupre J.N., Keenan M.J., Hegsted M., Brudevold A.M. Effects of dietary boron in rats fed a vitamin D-deficient diet. Environ. Health Perspect. 102(Suppl. 7):1994;55-58
7. Hunt C.D. Biochemical effects of physiological amounts of dietary boron. J. Trace Elem. Exp. Med. 9:1997;185-213
8. Kurtoglu V., Kurtoglu F., Coskun B. Effects of boron supplementation of adequate and inadequate vitamin D3-containing diet on performance and serum biochemical characters of broiler chickens. Res. Vet. Sci. 71:2001;183-187
9. Nielsen F.H., Mullen L.M., Gallegher S.K. Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet. J. Trace Elem. Exp. Med. 3:1990;45-54
10. Miljkovic N. Vitamin D/steroid homeostasis and calcium fructoborate supplementation, 2002 (unpublished manuscript)
11. Holick M.F. Vitamin D: A millenium perspective. J. Cell Biochem. 88:2003;296-307
12. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br. J. Nutr. 89:2003;552-572
13. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr. 69:1999;842-856
14. Vieth R., Chan P.C., MacFarlane G.D. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am. J. Clin. Nutr. 73:2001;288-294
15. Vieth R., Cole D.E., Hawker G.A., Trang H.M., Rubin L.A. Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it. Eur. J. Clin. Nutr. 55:2001;1091-1097
16. Lehtonen-Veromaa M., Mottonen T., Nuotio I., Irjala K., Viikari J. The effect of conventional vitamin D(2) supplementation on serum 25 (OH)D concentration is weak among peripubertal Finnish girls: a 3-y prospective study. Eur. J. Clin. Nutr. 56:2002;431-437
17. Nielsen F.H. The justification for providing dietary guidance for the nutritional intake of boron. Biol. Trace Elem. Res. 66:1998;319-330
18. Nielsen F.H., Hunt C.D., Mullen L.M., Hunt J.R. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J. 1:1987;394-397
19. Nielsen F.H. Biochemical and physiologic consequences of boron deprivation in humans. Environ. Health Perspect. 102(Suppl. 7):1994;59-63
20. Naghii M.R., Samman S. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol. Trace Elem. Res. 56:1997;273-286
21. Samman S., Naghii M.R., Lyons Wall P.M., Verus A.P. The nutritional and metabolic effects of boron in humans and animals. Biol. Trace Elem. Res. 66:1998;227-235