Thrombospondin-1 expression in relation to p53 status and VEGF expression in human breast cancers

European Journal of Cancer

Volumn 40, Issue 16, 2004, Pages 2417-2423

  Linderholm, Barbro ^a   Karlsson, Eva ^a   Klaar, Sigrid ^a   Lindahl, Thomas ^a   Borg, Anna Lena ^a   Elmberger, Göran ^a   Bergh, Jonas ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Angiogenesis; Breast cancer; p53; Thrombospondin; Vascular endothelial growth factor

Indexed keywords

COMPLEMENTARY DNA; PARAFFIN; PROTEIN P53; THROMBOSPONDIN 1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; RELAPSE; SURVIVAL RATE; TISSUE SECTION;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; THROMBOSPONDIN 1; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 7044238930     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2004.07.026     Document Type: Article

References (48)

1. J. Lawler The structural and functional properties of thrombospondin Blood 67 5 1986 1197 1209
2. N.L. Baenziger, G.N. Brodie, and P.W. Majerus Isolation and properties of a thrombin-sensitive protein of human platelets J Biol Chem 247 9 1972 2723 2731
3. P. Bornstein Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1 J Cell Biol 130 3 1995 503 506
4. D.L. Weinstat-Saslow, V.S. Zabrenetzky, K. VanHoutte, W.A. Frazier, D.D. Roberts, and P.S. Steeg Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis Cancer Res 54 24 1994 6504 6511
5. V. Zabrenetzky, C.C. Harris, P.S. Steeg, and D.D. Roberts Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines Int J Cancer 59 2 1994 191 195
6. S.C. Hsu, O.V. Volpert, P.A. Steck, T. Mikkelsen, P.J. Polverini, and S. Rao Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1 Cancer Res 56 24 1996 5684 5691
7. S.W. Grant, A.S. Kyshtoobayeva, T. Kurosaki, J. Jakowatz, and J.P. Fruehauf Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma Cancer Detect Prev 22 3 1998 185 194
8. A.A. Alvarez, J.R. Axelrod, R.S. Whitaker, P.D. Isner, R.C. Bentley, and R.K. Dodge Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients Gynecol Oncol 82 2 2001 273 278
9. T. Tokunaga, M. Nakamura, Y. Oshika, T. Tsuchida, M. Kazuno, and Y. Fukushima Alterations in tumour suppressor gene p53 correlate with inhibition of thrombospondin-1 gene expression in colon cancer cells Virchows Arch 433 5 1998 415 418
10. G.D. Grossfeld, D.A. Ginsberg, J.P. Stein, B.H. Bochner, D. Esrig, and S. Groshen Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression J Natl Cancer Inst 89 3 1997 219 227
11. R. Mehta, A. Kyshtoobayeva, T. Kurosaki, E.J. Small, H. Kim, and R. Stroup Independent association of angiogenesis index with outcome in prostate cancer Clin Cancer Res 7 1 2001 81 88
12. T.N. Wang, X. Qian, M.S. Granick, M.P. Solomon, V.L. Rothman, and D.H. Berger Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer J Surg Res 63 1 1996 39 43
13. S.Y. Wong, A.T. Purdie, and P. Han Thrombospondin and other possible related matrix proteins in malignant and benign breast disease. An immunohistochemical study Am J Pathol 140 6 1992 1473 1482
14. G.P. Tuszynski, T.B. Gasic, V.L. Rothman, K.A. Knudsen, and G.J. Gasic Thrombospondin, a potentiator of tumor cell metastasis Cancer Res 47 15 1987 4130 4133
15. D.A. Pratt, W.R. Miller, and J. Dawes Thrombospondin in malignant and non-malignant breast tissue Eur J Cancer Clin Oncol 25 2 1989 343 350
16. J. Dawes, P. Clezardin, and D.A. Pratt Thrombospondin in milk, other breast secretions, and breast tissue Semin Thromb Hemost 13 3 1987 378 384
17. P. Clezardin, L. Frappart, M. Clerget, C. Pechoux, and P.D. Delmas Expression of hrombospondin (TSP1) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplastic human breast Cancer Res 53 6 1993 1421 1430
18. J. Sjostrom, and J. Bergh How apoptosis is regulated, and what goes wrong in cancer BMJ 322 7301 2001 1538 1539
19. N. Ferrara Vascular endothelial growth factor Eur J Cancer 32A 14 1996 2413 2422
20. K.J. Kim, B. Li, J. Winer, M. Armanini, N. Gillett, and H.S. Phillips Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo Nature 362 6423 1993 841 844
21. B.K. Linderholm, T. Lindahl, L. Holmberg, S. Klaar, J. Lennerstrand, and R. Henriksson The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer Cancer Res 61 5 2001 2256 2260
22. J. Bergh, T. Norberg, S. Sjogren, A. Lindgren, and L. Holmberg Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy Nat Med 1 10 1995 1029 1034
23. B. Linderholm, K. Grankvist, N. Wilking, M. Johansson, B. Tavelin, and R. Henriksson Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment J Clin Oncol 18 7 2000 1423 1431
24. B. Linderholm, B. Tavelin, K. Grankvist, and R. Henriksson Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma J Clin Oncol 16 9 1998 3121 3128
25. S. Sjogren, M. Inganas, T. Norberg, A. Lindgren, H. Nordgren, and L. Holmberg The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry J Natl Cancer Inst 88 3-4 1996 173 182
26. G. Liljegren, L. Holmberg, J. Bergh, A. Lindgren, L. Tabar, and H. Nordgren 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial J Clin Oncol 17 8 1999 2326 2333
27. K. Wester, E. Wahlund, C. Sundstrom, P. Ranefall, E. Bengtsson, and P.J. Russell Paraffin section storage and immunohistochemistry. Effects of time, temperature, fixation, and retrieval protocol with emphasis on p53 protein and MIB1 antigen Appl Immunohistochem Mol Morphol 8 1 2000 61 70
28. P. Clezardin, J.L. McGregor, M. Lyon, K.J. Clemetson, and J. Huppert Characterization of two murine monoclonal antibodies (P10, P12) directed against different determinants on human blood platelet thrombospondin Eur J Biochem 154 1 1986 95 102
29. C. Legrand, V. Dubernard, N. Kieffer, and A.T. Nurden Use of a monoclonal antibody to measure the surface expression of thrombospondin following platelet activation Eur J Biochem 171 1-2 1988 393 399
30. K.M. McLaren Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets J Clin Pathol 36 2 1983 197 199
31. J.P. Girard, E.S. Baekkevold, T. Yamanaka, G. Haraldsen, P. Brandtzaeg, and F. Amalric Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization Am J Pathol 155 6 1999 2043 2055
32. D.M. Tolbert, A.E. Noffsinger, M.A. Miller, G.W. DeVoe, G.N. Stemmermann, and J.S. Macdonald p53 immunoreactivity and single-strand conformational polymorphism analysis often fail to predict p53 mutational status Mod Pathol 12 1 1999 54 60
33. U. Kressner, M. Inganas, S. Byding, I. Blikstad, L. Pahlman, and B. Glimelius Prognostic value of p53 genetic changes in colorectal cancer J Clin Oncol 17 2 1999 593 599
34. D.R. Smith, C.Y. Ji, and H.S. Goh Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas Br J Cancer 74 2 1996 216 223
35. B. Dix, P. Robbins, S. Carrello, A. House, and B. Iacopetta Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas Br J Cancer 70 4 1994 585 590
36. H. Mineta, A. Borg, M. Dictor, P. Wahlberg, J. Akervall, and J. Wennerberg p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinoma Br J Cancer 78 8 1998 1084 1090
37. P.M. Duddy, A.M. Hanby, D.M. Barnes, and R.S. Camplejohn Improving the detection of p53 mutations in breast cancer by use of the FASAY, a functional assay J Mol Diagn 2 3 2000 139 144
38. P.O. Chappuis, A. Estreicher, B. Dieterich, H. Bonnefoi, M. Otter, and A.P. Sappino Prognostic significance of p53 mutation in breast cancer: frequent detection of non-missense mutations by yeast functional assay Int J Cancer 84 6 1999 587 593
39. C.J. Fisher, C.E. Gillett, B. Vojtesek, D.M. Barnes, and R.R. Millis Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation Br J Cancer 69 1 1994 26 31
40. H.U. Kasper, M. Ebert, P. Malfertheiner, A. Roessner, C.J. Kirkpatrick, and H.K. Wolf Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density Virchows Arch 438 2 2001 116 120
41. O. Straume, and L.A. Akslen Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas Am J Pathol 159 1 2001 223 235
42. G. Gasparini, M. Toi, E. Biganzoli, R. Dittadi, M. Fanelli, and A. Morabito Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis Oncology 60 1 2001 72 80
43. K.M. Dameron, O.V. Volpert, M.A. Tainsky, and N. Bouck Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1 Science 265 5178 1994 1582 1584
44. M.L. Iruela-Arispe, M. Lombardo, H.C. Krutzsch, J. Lawler, and D.D. Roberts Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats Circulation 100 13 1999 1423 1431
45. J.E. Nor, R.S. Mitra, M.M. Sutorik, D.J. Mooney, V.P. Castle, and P.J. Polverini Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway J Vasc Res 37 3 2000 209 218
46. B. Jimenez, O.V. Volpert, S.E. Crawford, M. Febbraio, R.L. Silverstein, and N. Bouck Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1 Nat Med 6 1 2000 41 48
47. G. Taraboletti, L. Morbidelli, S. Donnini, A. Parenti, H.J. Granger, and R. Giavazzi The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells Faseb J 14 12 2000 1674 1676
48. L. Chandrasekaran, C.Z. He, H. Al-Barazi, H.C. Krutzsch, M.L. Iruela-Arispe, and D.D. Roberts Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1 Mol Biol Cell 11 9 2000 2885 2900