메뉴 건너뛰기




Volumn 11, Issue 3-4, 2004, Pages 215-220

The intrathymic pathogenesis of myasthenia gravis

Author keywords

Acetylcholine receptor; Intrathymic expression; Myasthenia gravis; Thymus

Indexed keywords

AUTOANTIGEN; CHOLINERGIC RECEPTOR;

EID: 7044235102     PISSN: 17402522     EISSN: None     Source Type: Journal    
DOI: 10.1080/17402520400001769     Document Type: Conference Paper
Times cited : (20)

References (50)
  • 1
    • 0025817420 scopus 로고
    • Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self-antigen
    • Adelstein, S., Pritchard-Briscoe, H., Anderson, T.A., et al. (1991) "Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self-antigen", Science 251, 1223-1225.
    • (1991) Science , vol.251 , pp. 1223-1225
    • Adelstein, S.1    Pritchard-Briscoe, H.2    Anderson, T.A.3
  • 2
    • 0025878150 scopus 로고
    • Reentry of T cells to the adult thymus is restricted to activavted cells
    • Agus, D., Surh, C.D. and Sprent, J. (1991) "Reentry of T cells to the adult thymus is restricted to activavted cells", J. Exp. Med. 173, 1039-1046.
    • (1991) J. Exp. Med. , vol.173 , pp. 1039-1046
    • Agus, D.1    Surh, C.D.2    Sprent, J.3
  • 5
    • 0025313553 scopus 로고
    • The human muscle nicotinic acetylcholine receptor α-subunit exists as two isoforms: A novel exon
    • Beeson, D., Morris, A., Vincent, A. and Newsom-Davis, J. (1990) "The human muscle nicotinic acetylcholine receptor α-subunit exists as two isoforms: a novel exon", EMBO 9, 2101-2106.
    • (1990) EMBO , vol.9 , pp. 2101-2106
    • Beeson, D.1    Morris, A.2    Vincent, A.3    Newsom-Davis, J.4
  • 6
    • 0022358987 scopus 로고
    • Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells
    • Berrih-Aknin, S., Arenzana-Seisdedos, F., Cohen, S., Devos, R., Charron, D. and Virelizier, J. (1985) "Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells", J. Immunol. 35, 1165-1171.
    • (1985) J. Immunol. , vol.35 , pp. 1165-1171
    • Berrih-Aknin, S.1    Arenzana-Seisdedos, F.2    Cohen, S.3    Devos, R.4    Charron, D.5    Virelizier, J.6
  • 7
    • 0025368646 scopus 로고
    • The role of the TCR in positive and negative selection of developing cells
    • Blackman, M., Kappler, J. and Marrack, P. (1990) "The role of the TCR in positive and negative selection of developing cells", Science 248, 1335-1341.
    • (1990) Science , vol.248 , pp. 1335-1341
    • Blackman, M.1    Kappler, J.2    Marrack, P.3
  • 8
    • 0027450835 scopus 로고
    • Thymus epithelium induces tissue-specific tolerance
    • Bonomo, A. and Matzinger, P. (1993) "Thymus epithelium induces tissue-specific tolerance", J. Exp. Med. 177, 1153-1164.
    • (1993) J. Exp. Med. , vol.177 , pp. 1153-1164
    • Bonomo, A.1    Matzinger, P.2
  • 9
    • 1542500767 scopus 로고    scopus 로고
    • Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus
    • Bruno, R., Sabater, L., Tolosa, E., et al. (2004) "Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus", J. Neuroimaging 149, 147-159.
    • (2004) J. Neuroimaging , vol.149 , pp. 147-159
    • Bruno, R.1    Sabater, L.2    Tolosa, E.3
  • 11
    • 0025997456 scopus 로고
    • Synergistic induction of interleukin-6 production and gene expression in human thymic epithelial cells by LPS and cytokines
    • Cohen-Kaminsky, S., Delattre, R., Devergne, O., et al. (1978) "Synergistic induction of interleukin-6 production and gene expression in human thymic epithelial cells by LPS and cytokines", Cell Immunol. 138, 79-93.
    • (1978) Cell Immunol. , vol.138 , pp. 79-93
    • Cohen-Kaminsky, S.1    Delattre, R.2    Devergne, O.3
  • 13
    • 0025845202 scopus 로고
    • In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients
    • Emilie, D., Creven, M.C., Cohen-Kaminsky, S., et al. (1991) "In situ production of interleukins in hyperplastic thymus from myasthenia gravis patients", Hum. Pathol. 22, 461-468.
    • (1991) Hum. Pathol. , vol.22 , pp. 461-468
    • Emilie, D.1    Creven, M.C.2    Cohen-Kaminsky, S.3
  • 14
    • 0017778351 scopus 로고
    • Thymic epithelial cells contain acetylcholine receptor
    • Engel, W., Trotter, J.L., MacFarlin, D.E. and McIntosh, C.L. (1977) "Thymic epithelial cells contain acetylcholine receptor", Lancet 1, 1310-1311.
    • (1977) Lancet , vol.1 , pp. 1310-1311
    • Engel, W.1    Trotter, J.L.2    MacFarlin, D.E.3    McIntosh, C.L.4
  • 15
    • 0019119327 scopus 로고
    • Thymic lymphocytes bear a surface antigen which cross-reacts with acetylcholine receptor
    • Fuchs, S., Schmidt-Hopfeldd, I. and Tridente, G. (1980) "Thymic lymphocytes bear a surface antigen which cross-reacts with acetylcholine receptor", Nature 287, 162-164.
    • (1980) Nature , vol.287 , pp. 162-164
    • Fuchs, S.1    Schmidt-Hopfeldd, I.2    Tridente, G.3
  • 16
    • 0023935543 scopus 로고
    • Specificity of the T cell immune response to acetylcholine receptor in experimental autoimmune myasthenia gravis
    • Fuji, Y. and Lindstrom, J. (1988) "Specificity of the T cell immune response to acetylcholine receptor in experimental autoimmune myasthenia gravis", J. Immunol. 140, 1830-1837.
    • (1988) J. Immunol. , vol.140 , pp. 1830-1837
    • Fuji, Y.1    Lindstrom, J.2
  • 17
    • 0025787986 scopus 로고
    • IL-1, IL-4, and IFN-γ differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells
    • Galy, A.H. and Spits, H. (1991) "IL-1, IL-4, and IFN-γ differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells", J. Immunol. 147, 3823-3830.
    • (1991) J. Immunol. , vol.147 , pp. 3823-3830
    • Galy, A.H.1    Spits, H.2
  • 18
    • 0026078188 scopus 로고
    • Entry of antivirally active T lymphocytes into the thymus of virus-infected mice
    • Gossmann, J., Lohler, J. and Lehmann-Grube, F. (1991) "Entry of antivirally active T lymphocytes into the thymus of virus-infected mice", J. Immunol. 146, 293-297.
    • (1991) J. Immunol. , vol.146 , pp. 293-297
    • Gossmann, J.1    Lohler, J.2    Lehmann-Grube, F.3
  • 19
    • 0000768235 scopus 로고
    • The route of re-circulation of lymphocytes in the rat
    • Gowans, J.L. and Knight, E. (1964) "The route of re-circulation of lymphocytes in the rat", Proc. R. Soc. Lond. B 159, 257-282.
    • (1964) Proc. R. Soc. Lond. B , vol.159 , pp. 257-282
    • Gowans, J.L.1    Knight, E.2
  • 20
    • 0028237278 scopus 로고
    • Nicotinic acetylcholine receptor a subunit variants in human myasthenia gravis: Quantification of steady-state levels of messenger RNA in muscle biopsy using the polymerase chain reaction
    • Guyon, T., Levasseur, P., Truffault, F., Cottin, C., Ohta, K., Itoh, N. and Ohta, M. (1993) "Nicotinic acetylcholine receptor a subunit variants in human myasthenia gravis: quantification of steady-state levels of messenger RNA in muscle biopsy using the polymerase chain reaction", J. Clin. Investig. 94, 16.
    • (1993) J. Clin. Investig. , vol.94 , pp. 16
    • Guyon, T.1    Levasseur, P.2    Truffault, F.3    Cottin, C.4    Ohta, K.5    Itoh, N.6    Ohta, M.7
  • 21
    • 0024539325 scopus 로고
    • Immunohistological analysis of immigration of thymocyte-precursors into the thymus: Evidence for immigration of peripheral T cells into the thymic medulla
    • Hirokawa, K., Utsuyama, M. and Sado, T. (1989) "Immunohistological analysis of immigration of thymocyte-precursors into the thymus: evidence for immigration of peripheral T cells into the thymic medulla", Cell Immunol. 119, 160-170.
    • (1989) Cell Immunol. , vol.119 , pp. 160-170
    • Hirokawa, K.1    Utsuyama, M.2    Sado, T.3
  • 23
    • 0028218815 scopus 로고
    • Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion
    • Hugo, P., Kappler, J.W., Godfrey, D.I. and Marrack, P.C. (1994) "Thymic epithelial cell lines that mediate positive selection can also induce thymocyte clonal deletion", J. Immunol. 152, 1022-1031.
    • (1994) J. Immunol. , vol.152 , pp. 1022-1031
    • Hugo, P.1    Kappler, J.W.2    Godfrey, D.I.3    Marrack, P.C.4
  • 24
    • 0026648978 scopus 로고
    • Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes
    • Iwabuchi, K., Nakayama, K.I., Mc Coy, R.L., et al. (1992) "Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes", Proc. Natl Acad. Sci. 89, 9000-9004.
    • (1992) Proc. Natl Acad. Sci. , vol.89 , pp. 9000-9004
    • Iwabuchi, K.1    Nakayama, K.I.2    Mc Coy, R.L.3
  • 25
    • 0017329788 scopus 로고
    • Thymic muscle cells bear acetylcholine receptors: Possible relation to myasthenia gravis
    • Kao, I. and Drachman, D.B. (1977) "Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis", Science 195, 74-75.
    • (1977) Science , vol.195 , pp. 74-75
    • Kao, I.1    Drachman, D.B.2
  • 26
    • 0025220175 scopus 로고
    • Negative and positive selection of immature thymocytes: Timing and the role of the ligand for T cell receptor
    • Kisielow, P. and Boehmer, M.V. (1990) "Negative and positive selection of immature thymocytes: timing and the role of the ligand for T cell receptor", Semin. Immunol. 2, 35-44.
    • (1990) Semin. Immunol. , vol.2 , pp. 35-44
    • Kisielow, P.1    Boehmer, M.V.2
  • 27
    • 0033673148 scopus 로고    scopus 로고
    • Promiscuous expression of tissue antigens in the thymus: A key to T-cell tolerance and autoimmunity?
    • Klein, L. and Kyewski, B. (2000) "Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?", J. Mol. Med. 78, 483-494.
    • (2000) J. Mol. Med. , vol.78 , pp. 483-494
    • Klein, L.1    Kyewski, B.2
  • 28
    • 0029988314 scopus 로고
    • The thymus and the pathogenesis of myasthenia gravis
    • Levinson, A.I. and Wheatley, L. (1995) "The thymus and the pathogenesis of myasthenia gravis", Clin. Immunol. Immunopathol. 78, 1-5.
    • (1995) Clin. Immunol. Immunopathol. , vol.78 , pp. 1-5
    • Levinson, A.I.1    Wheatley, L.2
  • 29
    • 0023225233 scopus 로고
    • Immunopathogenesis and treatment of myasthenia gravis
    • Levinson, A.I., Zweiman, B. and Lisak, R.P. (1987) " Immunopathogenesis and treatment of myasthenia gravis", J. Clin. Immunol. 7, 187-197.
    • (1987) J. Clin. Immunol. , vol.7 , pp. 187-197
    • Levinson, A.I.1    Zweiman, B.2    Lisak, R.P.3
  • 30
    • 7044234317 scopus 로고    scopus 로고
    • Myasthenia Gravis
    • Rich, R., et al., eds, (St. Louis),Levinson, A.I., Zheng, Y., Gaulton, S., Moore, J., Pletcher, C.H., Song, D. and Wheatley, L.M.
    • Levinson, A.I. (2001a) "Myasthenia Gravis", In: Rich, R., et al., eds, Principles and Practice of Clinical Immunology (St. Louis), Vol. 2. Levinson, A.I., Zheng, Y., Gaulton, S., Moore, J., Pletcher, C.H., Song, D. and Wheatley, L.M.
    • (2001) Principles and Practice of Clinical Immunology , vol.2
    • Levinson, A.I.1
  • 31
    • 0141727694 scopus 로고    scopus 로고
    • A new model linking intrathymic acetylcholine receptor expression and the pathogenesis of myasthenia gravis
    • (2001b) "A new model linking intrathymic acetylcholine receptor expression and the pathogenesis of myasthenia gravis", Ann. Acad. Sci. 998, 257-265.
    • Ann. Acad. Sci , vol.998 , pp. 257-265
  • 32
    • 0030461577 scopus 로고    scopus 로고
    • The role of the immune response in MuLV-induced lymphomagenesis
    • Marshall, D.J. and Gaulton, G.N. (1996) "The role of the immune response in MuLV-induced lymphomagenesis", Leukemia 10, 1860-1866.
    • (1996) Leukemia , vol.10 , pp. 1860-1866
    • Marshall, D.J.1    Gaulton, G.N.2
  • 33
    • 0024256095 scopus 로고
    • Rare peripheral T cells migrate to and persist in normal mouse thymus
    • Michie, S.A., Kirkpatrick, E.A. and Rouse, R.V. (1988) "Rare peripheral T cells migrate to and persist in normal mouse thymus", J. Exp. Med. 168, 1929-1934.
    • (1988) J. Exp. Med. , vol.168 , pp. 1929-1934
    • Michie, S.A.1    Kirkpatrick, E.A.2    Rouse, R.V.3
  • 34
    • 0029880520 scopus 로고    scopus 로고
    • The anatomy of T-cell activation and tolerance
    • Mondino, A., Khourts, A. and Jenkins, M.K. (1996) "The anatomy of T-cell activation and tolerance", Proc. Natl Acad. Sci. 3, 2245-2252.
    • (1996) Proc. Natl Acad. Sci. , vol.3 , pp. 2245-2252
    • Mondino, A.1    Khourts, A.2    Jenkins, M.K.3
  • 35
    • 0020421489 scopus 로고
    • Effector T lymphocyte line cells migrate to the thymus and persist there
    • Naparstek, Y., Holoshitz, J., Eissenstein, S., et al. (1982) "Effector T lymphocyte line cells migrate to the thymus and persist there", Nature 300, 262-264.
    • (1982) Nature , vol.300 , pp. 262-264
    • Naparstek, Y.1    Holoshitz, J.2    Eissenstein, S.3
  • 36
    • 0020529974 scopus 로고
    • T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells
    • Naparstek, Y., Ben-Nun, A., Holoshitz, J., et al. (1993) "T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells", Eur. J. Immunol. 13, 418-423.
    • (1993) Eur. J. Immunol. , vol.13 , pp. 418-423
    • Naparstek, Y.1    Ben-Nun, A.2    Holoshitz, J.3
  • 37
    • 0035145379 scopus 로고    scopus 로고
    • Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the δ subunit
    • Naveneetham, D., Penn, A.S., Howard, J.F. and Conti-Fine, B.M. (2001) "Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the δ subunit", Muscle Nerve 24, 203-210.
    • (2001) Muscle Nerve , vol.24 , pp. 203-210
    • Naveneetham, D.1    Penn, A.S.2    Howard, J.F.3    Conti-Fine, B.M.4
  • 38
    • 0027968081 scopus 로고
    • Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels
    • Oehen, S.U., Ohashi, P.S., Burki, K., Hengartner, H., Zinkemagel, R.M. and Aichele, P. (1994) "Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels", Cell Immunol. 158, 342-352.
    • (1994) Cell Immunol. , vol.158 , pp. 342-352
    • Oehen, S.U.1    Ohashi, P.S.2    Burki, K.3    Hengartner, H.4    Zinkemagel, R.M.5    Aichele, P.6
  • 39
    • 0025639188 scopus 로고
    • Autoimunne T cell recognition of human acetylcholine receptor: The sites of T cell recognition in myasthenia gravis on the extracellular part of the a-subunit
    • Oshima, M., Ashizawa, T., Pollack, M.S. and Atassi, M.Z. (1990) "Autoimunne T cell recognition of human acetylcholine receptor: the sites of T cell recognition in myasthenia gravis on the extracellular part of the a-subunit", Eur. J. Immunol. 20, 2563-2569.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2563-2569
    • Oshima, M.1    Ashizawa, T.2    Pollack, M.S.3    Atassi, M.Z.4
  • 40
    • 0023189057 scopus 로고
    • Acetylcholine receptor in human thymic myoid cells in situ: An immunologic study
    • Schluep, M.N., Wilcox, N., Vincent, A., Dhoot, G.K. and Newsom-Davis, J. (1987) "Acetylcholine receptor in human thymic myoid cells in situ: an immunologic study", Ann. Neurol. 22, 212-222.
    • (1987) Ann. Neurol. , vol.22 , pp. 212-222
    • Schluep, M.N.1    Wilcox, N.2    Vincent, A.3    Dhoot, G.K.4    Newsom-Davis, J.5
  • 41
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmunity
    • Shevach, E. (2000) "Regulatory T cells in autoimmunity", Adv. Rev. Immunol. 18, 423-449.
    • (2000) Adv. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.1
  • 42
    • 0023818566 scopus 로고
    • T cell selection in the thymus
    • Sprent, J., Lo, D., Gao, E.K. and Ron, Y. (1988) "T cell selection in the thymus", Immunol. Rev. 101, 173-190.
    • (1988) Immunol. Rev. , vol.101 , pp. 173-190
    • Sprent, J.1    Lo, D.2    Gao, E.K.3    Ron, Y.4
  • 43
    • 0030587964 scopus 로고
    • Expression of acetylcholine receptor genes in human thymic epithelial cells. Implications for myasthenia gravis
    • Wakkach, A., Guyon, T., Bruand, C., Tzartos, S., Cohen-Kaminsky, S. and Berrih-Aknin, S. (1978) "Expression of acetylcholine receptor genes in human thymic epithelial cells. Implications for myasthenia gravis", J. Immunol. 157, 3752-3760.
    • (1978) J. Immunol. , vol.157 , pp. 3752-3760
    • Wakkach, A.1    Guyon, T.2    Bruand, C.3    Tzartos, S.4    Cohen-Kaminsky, S.5    Berrih-Aknin, S.6
  • 44
    • 0018075584 scopus 로고
    • Intrathymic pathogenesis of myasthenia gravis: Transient expression of acetylcholine receptors on thymus-derived myogenic cells
    • Wekerle, H., Ketelson, U.P., Zurn, A.D. and Fulpius, B.W. (1978) "Intrathymic pathogenesis of myasthenia gravis: transient expression of acetylcholine receptors on thymus-derived myogenic cells", Eur. J. Immunol. 8, 579-582.
    • (1978) Eur. J. Immunol. , vol.8 , pp. 579-582
    • Wekerle, H.1    Ketelson, U.P.2    Zurn, A.D.3    Fulpius, B.W.4
  • 45
    • 0029832966 scopus 로고
    • Both activated and nonactivated leukocytes from the periphery continuously enter the thymic medulla of adult rats: Phenotypes, sources and magnitude of traffic
    • Westermann, J., Smith, T., Peters, U., et al. (1991) "Both activated and nonactivated leukocytes from the periphery continuously enter the thymic medulla of adult rats: phenotypes, sources and magnitude of traffic", Eur. J. Immunol. 26, 1866-1874.
    • (1991) Eur. J. Immunol. , vol.26 , pp. 1866-1874
    • Westermann, J.1    Smith, T.2    Peters, U.3
  • 46
    • 0026577251 scopus 로고
    • Molecular characterization of the nicotinic acetylcholine receptor alpha chain in mouse thymus
    • Wheatley, L.M., Urso, D., Tumas, K., Maltzman, J., Loh, E. and Levinson, A.I. (1992) "Molecular characterization of the nicotinic acetylcholine receptor alpha chain in mouse thymus", J. Immunol. 148, 3105-3109.
    • (1992) J. Immunol. , vol.148 , pp. 3105-3109
    • Wheatley, L.M.1    Urso, D.2    Tumas, K.3    Maltzman, J.4    Loh, E.5    Levinson, A.I.6
  • 47
    • 0027194312 scopus 로고
    • Molecular analysis of intrathymic nicotinic acetylcholine receptor
    • Wheatley, L.M., Urso, D., Zheng, Y., Loh, E. and Levinson, A.I. (1993) "Molecular analysis of intrathymic nicotinic acetylcholine receptor", Ann. NY Acad. Sci. 681, 74-82.
    • (1993) Ann. NY Acad. Sci. , vol.681 , pp. 74-82
    • Wheatley, L.M.1    Urso, D.2    Zheng, Y.3    Loh, E.4    Levinson, A.I.5
  • 48
    • 0025647297 scopus 로고
    • Immunologic heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenic patients
    • Zhang, Y., Schluep, M., Frutiger, S., Hughes, G.J., Jeannet, M., Steck, A. and Barkas, T. (1990a) "Immunologic heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenic patients", Eur. J. Immunol. 20, 2577-2583.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2577-2583
    • Zhang, Y.1    Schluep, M.2    Frutiger, S.3    Hughes, G.J.4    Jeannet, M.5    Steck, A.6    Barkas, T.7
  • 49
    • 0025647297 scopus 로고
    • Immunologic heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenic patients
    • Zhang, Y., Schluep, M., Frutiger, S., Hughes, G.J., Jeannet, M., Steck, A. and Barkas, T. (1990b) "Immunologic heterogeneity of autoreactive T lymphocytes against the nicotinic acetylcholine receptor in myasthenic patients", Eur J. Immunol. 20, 2577-2583.
    • (1990) Eur J. Immunol. , vol.20 , pp. 2577-2583
    • Zhang, Y.1    Schluep, M.2    Frutiger, S.3    Hughes, G.J.4    Jeannet, M.5    Steck, A.6    Barkas, T.7
  • 50
    • 0032952547 scopus 로고    scopus 로고
    • Acetylcholine receptor alpha subnit mRNA expression in human thymus: Augmented expression in myasthenia gravis and upregulation by interferon-γ
    • Zheng, Y., Wheatley, L.M., Liu, T. and Levinson, A.I. (1999) "Acetylcholine receptor alpha subnit mRNA expression in human thymus: augmented expression in myasthenia gravis and upregulation by interferon-γ, Clin. Immunol. 1, 170-177.
    • (1999) Clin. Immunol. , vol.1 , pp. 170-177
    • Zheng, Y.1    Wheatley, L.M.2    Liu, T.3    Levinson, A.I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.