Stem Cell Therapy for the Broken Heart: Mini-Organ Transplantation

Transplantation Proceedings

Volumn 41, Issue 8, 2009, Pages 3353-3357

  Mansour, S ^a   Roy, D C ^b   Lemieux, B ^c   Ouellet, C ^a   Stevens, L M ^a   Noiseux, N ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^c NOTRE DAME HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; CD34 ANTIBODY; CREATINE KINASE MB; PLACEBO; TROPONIN;

ACUTE HEART INFARCTION; ADULT; AGED; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEMATOPOIETIC STEM CELL; HUMAN; MALE; NEOVASCULARIZATION (PATHOLOGY); ORGAN TRANSPLANTATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEM CELL TRANSPLANTATION; TAKOTSUBO CARDIOMYOPATHY;

EID: 70350767306     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.08.033     Document Type: Article

References (17)

1. Topol E.J. Current status and future prospects for acute myocardial infarction therapy. Circulation 108 Suppl 1 (2003) III6
2. Dowell J.D., Rubart M., Pasumarthi K.B., et al. Myocyte and myogenic stem cell transplantation in the heart. Cardiovasc Res 58 (2003) 336
3. Hassink R.J., Brutelde la Riviere A., et al. Transplantation of cells for cardiac repair. J Am Coll Cardiol 41 (2003) 711
4. Orlic D., Kajstura J., Chimenti S., et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 98 (2001) 10344
5. Wollert K.C., and Drexler H. Clinical applications of stem cells for the heart. Circ Res 96 (2005) 151
6. Noiseux N., Gnecchi M., Lopez-Ilasaca M., et al. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol Ther 14 (2006) 840
7. Strauer B.E., Brehm M., Zeus T., et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106 (2002) 1913
8. Schachinger V., Assmus B., Britten M.B., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol 44 (2004) 1690
9. Schachinger V., Erbs S., Elsasser A., et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355 (2006) 1210
10. Meyer G.P., Wollert K.C., Lotz J., et al. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113 (2006) 1287
11. Lunde K., Solheim S., Aakhus S., et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 355 (2006) 1199
12. Janssens S., Dubois C., Bogaert J., et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367 (2006) 113
13. Kocher A.A., Schuster M.D., Szabolcs M.J., et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7 (2001) 430
14. Quirici N., Soligo D., Caneva L., et al. Differentiation and expansion of endothelial cells from human bone marrow CD133(+) cells. Br J Haematol 115 (2001) 186
15. Bartunek J., Vanderheyden M., Vandekerckhove B., et al. Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation 112 9 suppl I (2005) 178
16. Murry C.E., Soonpaa M.H., Reinecke H., et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428 (2004) 664
17. Rosenzweig A. Cardiac cell therapy-mixed results from mixed cells. N Engl J Med 355 (2006) 1274