Dramatic resolution of respiratory symptoms with imatinib mesylate in patients with chronic myeloid leukemia presenting with lower airway symptoms resembling asthma

Leukemia and Lymphoma

Volumn 50, Issue 10, 2009, Pages 1721-1722

  Ramanujam, Deivasikamani ^a   McNicholl, Feargal ^b   Furby, Darshayani ^c   Richardson, Deborah ^c   Cuthbert, Robert J G ^a   McMullin, Mary F ^a  

^a BELFAST CITY HOSPITAL   (United Kingdom)

^b ALTNAGELVIN HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CORTICOSTEROID; DASATINIB; HYDROXYUREA; IMATINIB; PREDNISOLONE; SALBUTAMOL;

ADULT; AIR TEMPERATURE; ASTHMA; CANCER REGRESSION; CASE REPORT; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; CORTICOSTEROID THERAPY; COUGHING; DISEASE ASSOCIATION; DISEASE COURSE; DRUG DOSE INCREASE; DYSPNEA; EXERCISE INDUCED ASTHMA; GENERAL CONDITION IMPROVEMENT; HUMAN; LETTER; LEUKOCYTOSIS; MALE; NEUTROPHILIA; NIGHT SWEAT; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; RELAPSE; THERAPY EFFECT; TREATMENT RESPONSE; WEIGHT REDUCTION;

ADULT; ANTINEOPLASTIC AGENTS; ASTHMA, EXERCISE-INDUCED; B-LYMPHOCYTES; COUGH; DIAGNOSTIC ERRORS; DYSPNEA; EXERCISE; HUMANS; LEUKEMIA, MYELOID, CHRONIC-PHASE; LEUKOTRIENE C4; MALE; PARANEOPLASTIC SYNDROMES; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; REMISSION INDUCTION;

EID: 70350765040     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190903161059     Document Type: Letter

References (5)

1. Roos C, Stenke L, Ohm L, et al. Clinical imatinib mesylate treatment induces early normalization of aberrant leukotrine C4 synthase expression and activity in chronic myeloid leukaemia. Br J Haematol 2008;142:992-995.
2. Hilberg T, Deigner HP, Mö ller E, et al. Transcription in response to physical stress -clues to the molecular mechanisms of exercise-induced asthma. FASEB J 2005;19: 1492-1494.
3. Hilberg T. Etiology of exercise-induced asthma: Physical stressinduced transcription. Allergy Asthma Rep 2007;7:27-32.
4. Berlin AA, Lukacs NW. Treatment of cockroach allergen asthma model with imatinib attenuates airway responses. Am J Respir Crit Care Med 2005;171:35-39.
5. Leis JF, Primack SL, Schubach SE, et al. Management of lifethreatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. Haematologica 2004;89:102-103.