Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players

International Journal of Molecular Medicine

Volumn 24, Issue 4, 2009, Pages 487-494

  Yoshimura, Masafumi ^a,b   Sakamoto, Koji ^c   Tsuruta, Akifumi ^d   Yamamoto, Tetsuro ^e   Ishida, Kaori ^e   Yamaguchi, Hideyo ^e   Nagaoka, Isao ^a,b  

^a JUNTENDO UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Koyo Chemical Co Ltd   (Japan)

^d ADVANCED INSTITUTE OF INDUSTRIAL TECHNOLOGY   (Japan)

^e TTC Co Ltd   (Japan)

Author keywords

Biomarkers; Cartilage; Collagen; Glucosamine; Sports

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; BIOLOGICAL MARKER; COLLAGEN TYPE 2; DEOXYPYRIDINOLINE; EPITOPE; GLUCOSAMINE;

ADULT; ARTICLE; ARTICULAR CARTILAGE; ATHLETE; BONE METABOLISM; CARTILAGE INJURY; CHONDROPROTECTION; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DISEASE MARKER; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN URINE LEVEL;

ADULT; CARTILAGE; COLLAGEN TYPE II; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCOSAMINE; HUMANS; JOINTS; MALE; YOUNG ADULT;

EID: 70350745942     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000257     Document Type: Article

References (32)

1. Roos H, Dahlberg L, Hoerrner LA, Lark MW, Thonar EJ, Shinmei M, Lindqvist U and Lohmander LS: Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise. Osteoarthr Cartil 3: 7-14, 1995.
2. Qi C and Changlin H: Effects of moving training on histology and biomarkers levels of articular cartilage. J Surg Res 135: 352-363, 2006.
3. Qi C, Changlin H and Zefeng H: Matrix metalloproteinases and inhibitor in knee synovial fluid as cartilage biomarkers in rabbits: the effect of high-intensity jumping exercise. J Surg Res 140: 149-157, 2007.
4. O'Kane JW, Hutchinson E, Atley LM and Eyre DR: Sport-related differences in biomarkers of bone resorption and cartilage degradation in endurance athletes. Osteoarthr Cartil 14: 71-76, 2006.
5. Kim HJ, Lee YH and Kim CK: Biomarkers of muscle and cartilage damage and inflammation during a 200 km run. Eur J Appl Physiol 99: 443-447, 2007.
6. Buckwalter JA and Lane NE: Does participation in sports cause osteoarthritis? Iowa Orthop J 17: 80-89, 1997.
7. Buckwalter JA and Lane NE: Athletics and osteoarthritis. Am J Sports Med 25: 873-881, 1997.
8. Garnero P, Rousseau JC and Delmas PD: Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases. Arthritis Rheum 43: 953-968, 2000.
9. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD and Vignon E: Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 60: 619-626, 2001.
10. Poole AR: Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis. Rheum Dis Clin North Am 29: 803-818, 2003.
11. Rousseau JC and Delmas PD: Biological markers in osteoarthritis. Nat Clin Pract Rheumatol 3: 346-356, 2007.
12. Christgau S, Garnero P, Fledelius C, Moniz C, Ensig M, Gineyts E, Rosenquist C and Qvist P: Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 29: 209-215, 2001.
13. Poole AR, Ionescu M, Fitzcharles MA and Billinghurst RC: The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases. J Immunol Methods 294: 145-153, 2004.
14. Shinmei M, Ito K, Matsuyama S, Yoshihara Y and Matsuzawa K: Joint fluid carboxy-terminal type II procollagen peptide as a marker of cartilage collagen biosynthesis. Osteoarthr Cartil 1: 121-128, 1993.
15. Schwenk TL and Costley CD: When food becomes a drug: nonanabolic nutritional supplement use in athletes. Am J Sports Med 30: 907-916, 2002.
16. Gorsline RT and Kaeding CC: The use of NSAIDs and nutritional supplements in athletes with osteoarthritis: prevalence, benefits, and consequences. Clin Sports Med 24: 71-82, 2005.
17. Ostojic SM and Arsic M, Prodanovic S, Vukovic J and Zlatanovic M: Glucosamine administration in athletes: effects on recovery of acute knee injury. Res Sports Med 15: 113-124, 2007.
18. McAlindon TE, Lavalley MP, Gulin JP and Felson DT: Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 283: 1469-1475, 2000.
19. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE and Gossett C: Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 357: 251-256, 2001.
20. Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G and Rovati LC: Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 162: 2113-2123, 2002.
21. Fenton JI, Chlebek-Brown KA, Peters TL, Caron JP and Orth MW: Glucosamine HCl reduces equine articular cartilage degradation in explant culture. Osteoarthr Cartil 8: 258-265, 2000.
22. Gouze JN, Bordji K, Gulberti S, Terlain B, Netter P, Magdalou J, Fournel-Gigleux S and Ouzzine M: Interleukin-1β downregulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1β-mediated effects in rat chondrocytes. Arthritis Rheum 44: 351-360, 2001.
23. 2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis. Clin Exp Rheumatol 22: 293-299, 2004.
24. Derfoul A, Miyoshi AD, Freeman DE and Tuan RS: Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthr Cartil 15: 646-655, 2007.
25. Cahue S, Sharma L, Dunlop D, Ionescu M, Song J, Lobanok T, King L and Poole AR: The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis. Osteoarthr Cartil 15: 819-823, 2007.
26. Sharif M, Kirwan J, Charni N, Sandell LJ, Whittles C and Garnero P: A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis - association with disease progression. Rheumatology 46: 938-943, 2007.
27. Radin EL and Rose RM: Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 213: 34-40, 1986.
28. Bettica P, Cline G, Hart DJ, Meyer J and Spector TD: Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study. Arthritis Rheum 46: 3178-3184, 2002.
29. Nakamura H, Masuko K, Yudoh K, Kato T, Kamada T and Kawahara T: Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int 27: 213-218, 2007.
30. Watari T, Naito K, Nagaoka I, Yoshimura M, Ishijima M, Yamamoto T, Ishida K, Yamaguchi H, Tomonaga A, Kaneko K and Kurosawa H: Evaluation of knee osteoarthritis using type II collagen-degradation marker C2C and -synthesis marker CPII. J Jap Knee Soc 33: 233-237, 2008.
31. Kellgren JH and Lawrence JS: Radiological assessment of rheumatoid arthritis. Ann Rheum Dis 16: 494-502, 1957.
32. Christgau S, Henrotin Y, Tankó LB, Rovati LC, Collette J, Bruyere O, Deroisy R and Reginster JY: Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate. Clin Exp Rheumatol 22: 36-42, 2004.