Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model

European Journal of Pharmacology

Volumn 624, Issue 1-3, 2009, Pages 66-70

  Sejima, Hitomi ^a   Tominaga, Koji ^a   Egawa, Takashi ^b   Ikeda, Munehiko ^a   Shibuya, Kohta ^a   Kameyama, Natsuko ^a   Yamauchi, Atsushi ^a   Shuto, Hideki ^a   Kataoka, Yasufumi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b SHUJITSU UNIVERSITY   (Japan)

Author keywords

Climacteric age; Gender difference; Hot flush; Nitrate; Phosphodiesterase type 5 inhibitor

Indexed keywords

ESTROGEN; ISOSORBIDE DINITRATE; MESSENGER RNA; NITRATE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; TADALAFIL; TESTOSTERONE; VARDENAFIL;

ANIMAL EXPERIMENT; ARTICLE; CLIMACTERIUM; CONTROLLED STUDY; FEMALE; FLUSHING; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; OVARIECTOMY; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SKIN TEMPERATURE; TAIL; TAIL ARTERY; VASODILATATION;

ANIMALS; CARBOLINES; CLIMACTERIC; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; FEMALE; FLUSHING; GENE EXPRESSION REGULATION; IMIDAZOLES; MALE; MICE; MICE, INBRED ICR; MODELS, ANIMAL; NITRATES; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RNA, MESSENGER; SEX CHARACTERISTICS; SKIN; SULFONES; TAIL; TRIAZINES;

EID: 70350745401     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.09.051     Document Type: Article

References (37)

1. Aversa A., Isidori A.M., Spera G., Lenzi A., and Fabbri A. Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction. Clin. Endocrinol. 58 (2003) 632-638
2. Baba K., Yajima M., Carrier S., Akkus E., Reman J., Nunes L., Lue T.F., and Iwamoto T. Effect of testosterone on the number of NADPH diaphorase-stained nerve fibers in the rat corpus cavernosum and dorsal nerve. Urology 56 (2000) 533-538
3. Chamness S.L., Ricker D.D., Crone J.K., Dembeck C.L., Maguire M.P., Burnett A.L., and Chang T.S. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil. Steril. 63 (1995) 1101-1107
4. Crews J.K., and Khalil R.A. Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin. Exp. Pharmacol. Physiol. 26 (1999) 707-715
5. Erlik Y., Meldrum D.R., and Judd H.H. Estrogen levels in postmenopausal women with hot flashes. Obstet. Gynecol. 59 (1982) 403-407
6. Freedman R.R. Physiology of hot flashes. Am. J. Human Biol. 13 (2001) 453-464
7. Guay A.T., Perez J.B., Jacobson J., and Newton R.A. Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors. J. Androl. 22 (2001) 793-797
8. Ikeda M., Egawa T., Yamauchi A., Sohda Y., Koga A., Tominaga K., Shuto H., and Kataoka Y. Selective serotonin reuptake inhibitors fluvoxamine and paroxetine restore forced exercise-induced temperature dysregulation in ovariectomized mice. Eur. J. Pharmacol. 579 (2008) 439-444
9. Iwatani Y., Kosugi K., Isobe-Oku S., Atagi S., Kitamura Y., and Kawasaki H. Endothelium removal augments endothelium-independent vasodilatation in rat mesenteric vascular bed. Br. J. Pharmacol. 154 (2008) 32-40
10. Kai M., Tominaga K., Okimoto K., Yamauchi A., Kai H., and Kataoka Y. Ovariectomy aggravates nifedipine-induced flushing of tail skin in mice. Eur. J. Pharmacol. 481 (2003) 79-82
11. Kanashiro C.A., and Khalil R.A. Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle. Am. J. Physiol. Cell Physiol. 280 (2001) C34-C45
12. Karling P., Hammar M., and Varenhorst E. Prevalence and duration of hot flushes after surgical or medical castration in men with prostatic carcinoma. J. Urol. 152 (1994) 1170-1173
13. Khalil R.A. Sex hormones as potential modulators of vascular function in hypertension. Hypertension 46 (2005) 249-254
14. Lewis R.W., and Mills T.M. Effect of androgens on penile tissue. Endocrine 23 (2004) 101-105
15. Lin C.S., Chow S., Lau A., Tu R., and Lue T.F. Identification and regulation of human PDE5A gene promoter. Biochem. Biophys. Res. Commun. 280 (2001) 684-692
16. Lugg J.A., Rajfer J., and González-Cadavid N.F. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 136 (1995) 1495-1501
17. Michelakis E.D., Tymchak W., Noga M., Webster L., Wu X.C., Lien D., Wang S.H., Modry D., and Archer S.L. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 108 (2003) 2066-2069
18. Mills T.M., Dai Y., Stopper V.S., and Lewis R.W. Androgenic maintenance of the erectile response in the rat. Steroids 64 (1999) 605-609
19. Moncada S., Rees D.D., Schulz R., and Palmer R.M. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 2166-2170
20. Morelli A., Filippi S., Mancina R., Luconi M., Vignozzi L., Marini M., Orlando C., Vannelli G.B., Aversa A., Natali A., Forti G., Giorgi M., Jannini E.A., Ledda F., and Maggi M. Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology 145 (2004) 2253-2263
21. Mostafa T. Oral phosphodiesterase type 5 inhibitors: nonerectogenic beneficial uses. J. Sex Med. 5 (2008) 2502-2518
22. Notelovitz M. Hot flashes and androgens: a biological rationale for clinical practice. Mayo Clin. Proc. 79 (2004) S8-S13
23. Orshal J.M., and Khalil R.A. Gender, sex hormones, and vascular tone. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (2004) R233-R249
24. Park K., Ku J.H., Kim S.W., and Paick J.S. Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction. BJU Int. 95 (2005) 366-370
25. Penson D.F., Ng C., Cai L., Rajfer J., and González-Cadavid N.F. Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biol. Reprod. 55 (1996) 567-574
26. Reilly C.M., Zamorano P., Stopper V.S., and Mills T.M. Androgenic regulation of NO availability in rat penile erection. J. Androl. 18 (1997) 110-115
27. Rosen R.C., and Kostis J.B. Overview of phosphodiesterase 5 inhibition in erectile dysfunction. Am. J. Cardiol. 92 (2003) 9M-18M
28. Sader M.A., and Celermajer D.S. Endothelial function, vascular reactivity and gender differences in the cardiovascular system. Cardiovasc. Res. 53 (2002) 597-604
29. Shabsigh R., Kaufman J.M., Steidle C., and Padma-Nathan H. Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. J. Urol. 172 (2004) 658-663
30. Shanafelt T.D., Barton D.L., Adjeu A.A., and Loprinzi C.L. Pathophysiology and treatment of hot flashes. Mayo Clin. Proc. 77 (2002) 1207-1218
31. Shuto H., Yamauchi A., Ikeda M., Sohda Y., Koga A., Tominaga K., Egawa T., and Kataoka Y. Forced exercise-induced flushing of tail skin in ovariectomized mice, as a new experimental model of menopausal hot flushes. J. Pharmacol. Sci. 98 (2005) 323-326
32. Spetz A.C., Fredriksson M.G., and Hammar M.L. Hot flushes in a male population aged 55, 65, and 75 years, living in the community of Linköping, Sweden. Menopause 10 (2003) 81-87
33. Stearns V., Ullmer L., Lopez J.F., Smith Y., Isaacs C., and Hayes D.F. Hot flushes. Lancet 360 (2002) 1851-1861
34. Thompson J., and Khalil R.A. Gender differences in the regulation of vascular tone. Clin. Exp. Pharmacol. Physiol. 30 (2003) 1-15
35. Thurston R.C., Sutton-Tyrrell K., Everson-Rose S.A., Hess R., and Matthews K.A. Hot flashes and subclinical cardiovascular disease: findings from the Study of Women's Health Across the Nation Heart Study. Circulation 118 (2008) 1234-1240
36. Traish A.M., Munarriz R., O'Connel L., Choi S., Kim S.W., Kim N.N., Huang Y.-H., and Goldstein I. Effects of medical or surgical castration on erectile function in an animal model. J. Androl. 24 (2003) 381-387
37. Zhang X.H., Morelli A., Luconi M., Vignozzi L., Filippi S., Marini M., Vannelli G.B., Mancina R., Forti G., and Maggi M. Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum. Eur. Urol. 47 (2005) 409-416