Role of SHP-2 in apoptosis of HEK293T cells induced by arsenic trioxide

Chinese Pharmacological Bulletin

Volumn 25, Issue 8, 2009, Pages 1086-1089

  Si, Yun Feng ^a   Zhu, Xiao Chun ^a   Sun, Dong Sheng ^a   Qi, Qi ^a   Wang, Guo Yuan ^a   Jin, Cheng Yan ^a   Wang, Li Na ^a   Xu, Chang Qing ^a   Tian, Ye ^a   Zhang, Li ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Arsenic trioxide; Cell signal transduction; ERK; HEK 293T cells; JNK; SHP 2

Indexed keywords

ARSENIC TRIOXIDE; CASPASE 3; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN TYROSINE PHOSPHATASE SHP 2;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY CELL; SIGNAL TRANSDUCTION;

EID: 70350732578     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Fisher D E. Apoptosis in cancer therapy: crossing the threshold [J]. Cell,1994,78:539-542
2. Qu C K. The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions[J]. Cell Res,2000,10(4):279-288
3. Zito C I, Kontaridis M I, Fornaro M, et al. SHP-2 regulates the phosphatidylinositide 3′-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis[J]. Cell Physiol,2004,199:227-36.
4. Miller WH Jr, Schipper H M, Lee J S, et al. Mechanisms of action of arsenic trioxide[J]. Cancer Res,2002,62:3893-3903
5. Zhou J, Meng R, Sui X H, et al. Effects of protein tyrosine kinase, protein tyrosine phosphatase and protein kinase C on the apoptosis of arsenic trioxide treated NB4 cells and human cortex neurons [J]. J Chin Hematol,2004,25(10):600-604
6. 3 on apoptosis and proliferation of 293t cells [J]. J Harbin Med Univ,2006,40(2):116-120
7. Qu C K. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response[J]. Biochim Biophys Acta,2002,1592(3):297-301.
8. Xing M, Zhang E J, Ye X. Investigation of the pathway of apoptosis induced by arsenic trioxide in cancer cells[J]. Chin Pharmacol Bull,2002,18(1):87-90.
9. Amin A R, Thakur V S, Paul R K, et al. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG[J]. Proc Natl Acad Sci USA, 2007,104:5419-5424
10. Yuan H, Yang S, Zhou W X, et al. MAPK cascade signaling and long-term potentiaion[J]. Chin Pharmacol Bull,2006,22(7):769-774