Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cells

International Journal of Cancer

Volumn 125, Issue 11, 2009, Pages 2528-2539

  Torosyan, Yelizaveta ^a   Simakova, Olga ^a   Naga, Shanmugam ^a   Mezhevaya, Katerina ^a   Leighton, Ximena ^a   Diaz, Juan ^a   Huang, Wei ^a   Pollard, Harvey ^a   Srivastava, Meera ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Annexin A7 vs. p53; AR; Ingenuity pathways analysis; Prostate cancer; RB E2F

Indexed keywords

ANDROGEN; APOPTOSIS SIGNAL REGULATING KINASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 7; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN 1; SYNEXIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; ANDROGEN RECEPTOR; AR PROTEIN, HUMAN; DNA; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ADENOVIRUS; CELL CYCLE; DNA MICROARRAY; DRUG EFFECT; DRUG RESISTANCE; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; MALE; METABOLISM; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; PROSTATE; PROSTATE TUMOR; TUMOR CELL CULTURE; WESTERN BLOTTING;

ADENOVIRIDAE; ANNEXIN A7; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENETIC VECTORS; HUMANS; MALE; NEOPLASMS, HORMONE-DEPENDENT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RETINOBLASTOMA PROTEIN; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 70350726354     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24592     Document Type: Article

References (47)

1. Srivastava M, Montagna C, Leighton X, Glasman M, Naga S, Eidelman O, Ried T, Pollard HB. Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Proc Natl Acad Sci USA 2003;100:14287-14292
2. Srivastava M, Bubendorf L, Srikantan V, Fossom L, Nolan L, Glasman M, Leighton X, Fehrle W, Pittaluga S, Raffeld M, Koivisto P, Willi N, et al. ANX7, a candidate tumor suppressor gene for prostate cancer. Proc Natl Acad Sci USA 2001;98: 4575-4580 (Pubitemid 32295018)
3. Leighton X, Srikantan V, Pollard HB, Sukumar S, Srivastava M. Significant allelic loss of ANX7 region (10q21) in hormone receptor negative breast carcinomas. Cancer Lett 2004;210:239-244 (Pubitemid 38748694)
4. Srivastava M, Torosyan Y, Raffeld M, Eidelman O, Pollard HB, Bubendorf L. ANXA7 expression represents hormone-relevant tumor suppression in different cancers. Int J Cancer 2007;121:2628-2636 (Pubitemid 350136405)
5. Sharma A, Comstock CE, Knudsen ES, Cao KH, Hess-Wilson JK, Morey LM, Barrera J, Knudsen KE. Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells. Cancer Res 2007;67:6192-6203 (Pubitemid 47037500)
6. Goodrich DW. The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene 2006;25:5233-5243
7. Helmbold H, Deppert W, Bohn W. Regulation of cellular senescence by Rb2/p130. Oncogene 2006;25:5257-5262
8. Wang X, Deng H, Basu I, Zhu L. Induction of androgen receptor-dependent apoptosis in prostate cancer cells by the retinoblastoma protein. Cancer Res 2004;64:1377-1385 (Pubitemid 38235606)
9. Balk SP, Knudsen KE. AR, the cell cycle, and prostate cancer. Nucl Recept Signal 2008;6:e001.
10. Li P, Nicosia SV, Bai W. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. J Biol Chem 2001;276:20444-20450 (Pubitemid 37411126)
11. Bookstein R, Shew JY, Chen PL, Scully P, Lee WH. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 1990;247:712-715 (Pubitemid 20054940)
12. Hemmati PG, Güner D, Gillissen B, Wendt J, von Haefen C, Chinnadurai G, Dörken B, Daniel PT. Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. Oncogene 2006; 25:6582-6594 (Pubitemid 44646186)
13. Tang Y, Eng C. p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction. Cancer Res 2006;66:6139-6148
14. Jorgensen P, Tyers M. How cells coordinate growth and division. Curr Biol 2004;14:R1014-R1027. (Pubitemid 39623187)
15. Lee C, Kim JS, Waldman T. PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells. Cancer Res 2004;64:6906-6914 (Pubitemid 39330998)
16. Fang SC, de los Reyes C, Umen JG. Cell size checkpoint control by the retinoblastoma tumor suppressor pathway. PLoS Genet 2006;2:e167.
17. Srivastava M, Eidelman O, Leighton X, Glasman M, Goping G, Pollard HB. Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans. Mol Med 2002;8:781-797 (Pubitemid 36223131)
18. Butler LM, Centenera MM, Neufing PJ, Buchanan G, Choong CS, Ricciardelli C, Saint K, Lee M, Ochnik A, Yang M, Brown MP, Tilley WD. Suppression of androgen receptor signaling in prostate cancer cells by an inhibitory receptor variant. Mol Endocrinol 2006;20:1009-1024
19. Pelley RP, Chinnakannu K, Murthy S, Strickland FM, Menon M, Dou QP, Barrack ER, Reddy GP. Calmodulin-androgen receptor (AR) interaction: calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cells. Cancer Res 2006;66:11754-11762 (Pubitemid 46094187)
20. Ahrens-Fath I, Politz O, Geserick C, Haendler B. Androgen receptor function is modulated by the tissue-specific AR45 variant. FEBS J 2005;272:74-84. (Pubitemid 40083068)
21. Yeh S, Miyamoto H, Nishimura K, Kang H, Ludlow J, Hsiao P, Wang C, Su C, Chang C. Retinoblastoma, a tumor suppressor, is a coactivator for the androgen receptor in human prostate cancer DU145 cells. Biochem Biophys Res Commun 1998;248:361-367 (Pubitemid 28386427)
22. Litvinov IV, Antony L, Dalrymple SL, Becker R, Cheng L, Isaacs JT. PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor. Prostate 2006;66:1329-1338 (Pubitemid 44384309)
23. Garner E, Raj K. Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death. Cell Cycle 2008;7:277-282
24. Yu F, Finley RL, Raz A, Kim HR. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation. J Biol Chem 2002;277:15819-15827 (Pubitemid 34967860)
25. Brownawell AM, Creutz CE. Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). J Biol Chem 1997;272:22182-22190
26. Mazurek N, Sun YJ, Price JE, Ramdas L, Schober W, Nangia-Makker P, Byrd JC, Raz A, Bresalier RS. Phosphorylation of galectin-3 contributes to malignant transformation of human epithelial cells via modulation of unique sets of genes. Cancer Res 2005;65:10767-10775 (Pubitemid 41713345)
27. Kim HR, Lin HM, Biliran H, Raz A. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Res 1999;59:4148-4154 (Pubitemid 29393591)
28. MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J 2007;26:784-794 (Pubitemid 46253833)
29. Sullivan A, Lu X. ASPP: a new family of oncogenes and tumour suppressor genes. Br J Cancer 2007;96:196-200. (Pubitemid 46160620)
30. Dasgupta P, Betts V, Rastogi S, Joshi B, Morris M, Brennan B, Ordonez-Ercan D, Chellappan S. Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery. J Biol Chem 2004;279:38762-38769
31. Tan J, Zhuang L, Jiang X, Yang KK, Karuturi KM, Yu Q. Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity. J Biol Chem 2006;281:10508-10515 (Pubitemid 43864590)
32. Milton AH, Khaire N, Ingram L, O'Donnell AJ, La Thangue NB. 14-3-3 proteins integrate E2F activity with the DNA damage response. EMBO J 2006;25:1046-1057 (Pubitemid 43372118)
33. Henrique R, Jerónimo C, Hoque MO, Carvalho AL, Oliveira J, Teixeira MR, Lopes C, Sidransky D. Frequent 14-3-3 sigma promoter methylation in benign and malignant prostate lesions. DNA Cell Biol 2005;24:264-269 (Pubitemid 40490265)
34. Lee MH, Lozano G. Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Semin Cancer Biol 2006;16:225-234 (Pubitemid 43796127)
35. Bansal P, Lazo JS. Induction of Cdc25B regulates cell cycle resumption after genotoxic stress. Cancer Res 2007;67:3356-3363 (Pubitemid 46724875)
36. Ngan ES, Hashimoto Y, Ma ZQ, Tsai MJ, Tsai SY. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Oncogene 2003;22:734-739 (Pubitemid 36269286)
37. Davis JN, Wojno KJ, Daignault S, Hofer MD, Kuefer R, Rubin MA, Day ML. Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. Cancer Res 2006;66:11897-11906 (Pubitemid 46094202)
38. Liao G, Chen LY, Zhang A, Godavarthy A, Xia F, Ghosh JC, Li H, Chen JD. Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. J Biol Chem 2003;278:5052-5061 (Pubitemid 36801015)
39. Nakajima H, Brindle PK, Handa M, Ihle JN. Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription. EMBO J 2001;20:6836-6844 (Pubitemid 33134213)
40. Carsol JL, Gingras S, Simard J. Synergistic action of prolactin (PRL) and androgen on PRL-inducible protein gene expression in human breast cancer cells: a unique model for functional cooperation between signal transducer and activator of transcription-5 and androgen receptor. Mol Endocrinol 2002;16:1696-1710
41. Calzone L, Gelay A, Zinovyev A, Radvanyl F, Barillot E. A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol 2008;4:173.
42. Mallik I, Davila M, Tapia T, Schanen B, Chakrabarti R. Androgen regulates Cdc6 transcription through interactions between androgen receptor and E2F transcription factor in prostate cancer cells. Biochim Biophys Acta 2008;1783:1737-1744
43. Libertini SJ, Tepper CG, Guadalupe M, Lu Y, Asmuth DM, Mudryj M. E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis. Prostate 2006;66:70-81.
44. Slee EA, Lu X. The ASPP family: deciding between life and death after DNA damage. Toxicol Lett 2003;139:81-87 (Pubitemid 36298965)
45. Lee EC, Zhan P, Schallhom R, Packman K, Tenniswood M. Antiandrogen-induced cell death in LNCaP human prostate cancer cells. Cell Death Differ 2003;10:761-771 (Pubitemid 36850237)
46. Paramio JM, Navarro M, Segrelles C, Gomez-Casero E, Jorcano JL. PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene 1999;18:7462-7468 (Pubitemid 30035047)
47. Mazurek N, Sun YJ, Liu KF, Gilcrease MZ, Schober W, Nangia-Makker P, Raz A, Bresalier RS. Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells. J Biol Chem 2007;282:21337-21348