Study on the molecular mechanism of C-phycocyanin from Spirulina platensis induced apoptosis in HeLa cells

Chinese Pharmacological Bulletin

Volumn 25, Issue 8, 2009, Pages 1045-1050

  Li, Bing ^a   Chu, Xian Ming ^a   Gao, Mei Hua ^a   Zhang, Xue Cheng ^b  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Antitumor; C phycocyanin; Cell apoptosis; HeLa cells; Signal transduction; Spirulina platensis

Indexed keywords

CASPASE; CYTOCHROME C; FAS ANTIGEN; GENOMIC DNA; INTERCELLULAR ADHESION MOLECULE 1; PHYCOCYANIN; PROTEIN BCL 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME RELEASE; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRION; SIGNAL TRANSDUCTION; SPIRULINA PLATENSIS;

EID: 70350718982     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Zhang C W, Zeng S Q, Zhang Y Z. Purification and physiochemical properties of phycobiliprotein of spirulina platensis [J]. Nat Prod Res Dev,1996,8(2):29-33.
2. Zhang X C. Spirulina - Most perfect functional food[M]. Qingdao: Publishing House of Ocean University of Qingdao, 1999:86-118.
3. Rito-Palomares M, Nunez L, Amador D. Practical application of aqueous two-phase systems for the development of a prototype process for c-Phycocyanin recovery form Spirulina maxima[J]. J Chem Technol Biotechnol,2001,76(12):1273- 1280
4. Schwartz J L, Sklar G. Growth inhibition and destruction of oral cancer cells by extracts of Spirulina[J]. Proc Amer Oral Pathol, 1986,40:23-27
5. Li B, Zhang X, Gao M, Chu X. Effects of CD59 on antitumoral activities of phycocyanin from Spirulina platensis [J]. Biomed Pharmacother,2005,59(10):551- 560
6. Cai X H, He L M, Jiang J L, et al. The experimental study of application of phycocyanin in cancer laser therapy [J]. Chin J Marine Drugs,1995,14(1): 15-18
7. Li B, Zhang X C, Gao M H, et al. Study on the antitumor immune activities of phycocyanin and polysaccharide from Spirulina platensis[J]. J Ocean Univ Qingdao,2004,34(3): 396-402.
8. Kerr J F, Winterford C M, Harmon B V. Apoptosis. Its signigicance in cancer and cancer therapy[J]. Cancer,1994,73(8):2013-26.
9. Steller H. Mechanisms and genes of cellular suicide[J]. Science, 1995,267(5203): 1445-1449
10. Cao B, Lei Z Y, Chen H X, et al. YB-13, a novel synthetic m icrotubule inhibitor, induces apoptosis of HeLa cells and itsmechanism [J]. Chin Pharmacol Bull,2008,24(1): 123-127
11. Riou D, Colliec-Jouaults S, pinczon du Sel D, et al. Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line [J]. Anticancer Res,1996,16(3A): 1213-1218
12. Richmond A. Spirulina. In: Borowitzka M A, Borowitzka L J (ed). Microalgal biotechnology. Cambridge: Cambridge University Press, 1988:85-121.
13. Morcos N C, Berns M, Henry W L. Phycocyanin: laser activation, cytotoxic effects, and uptake in human atherosclerotic plaque[J]. Lasers Surg Med,1988,8(1):10-17
14. Reddy M C, Subhashini J, Mahipal S V, et al. C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW264.7 macrophages [J]. Biochem Biophys Res Commun,2003,304(2):385-392
15. Pardhasaradhi B V, Ali A, Kumari A, et al. Phycocyanin mediated apoptosis in AK-5 tumor cells involves downregulation of Bcl-2 and generation of ROS[J]. Mol Cancer Ther,2003,2(11): 1165-70.
16. Qiao A M, Ikejima takashi, Zhang W G, et al. N-demethyl-clarithromycin induced HeLa apoptosis through regulating Akt and ERK activity[J]. Chin Pharmacol Bull,2007,23(3): 379-383
17. Wu Z, Wu L J, Tashiro S I, et al. Shikonin induce HeLa cell apoptosis via a caspase-dependent mechanism[J]. Chin Pharmacol Bull,2004,20(5): 540-544
18. Martinou J C, Desagher S, Antonsson B. Cytochrome c release from mitochondria: all or nothing[J]. Nat Cell Biol,2000,2(3): 41-3.
19. Huang Y L, Hu H J, Huang L M, et al. Molecular mechanism study of Trichosanthin induced apoptosis in human cervical carcinoma HeLa cells [J]. Chin Pharmacol Bull, 2007,23(1): 99-101.