Shikonin induce HeLa cell apoptosis via a caspase-dependent mechanism

Chinese Pharmacological Bulletin

Volumn 20, Issue 5, 2004, Pages 540-544

  Wu, Zhen ^a   Wu, Li Jun ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Anti tumor activity; Apoptosis; Caspase; HeLa cell; Shikonin

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; DNA FRAGMENT; FAS ANTIGEN; LACTATE DEHYDROGENASE; SHIKONIN; TUMOR NECROSIS FACTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ASSAY; CELL DEATH; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 4043103373     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Sankawa U, Otsuka H, Kataoka Y et al. Antitumor activity of shikonin, alkannin and their derivatives. Chem Pharm Bull, 1981;29(1):116-22
2. Tanaka S, Tajima M, Tsukada M, Tabata M. A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin. J of Natural Products, 1986;49(3):466-9
3. Sankawa U, Ebizuka Y, Miyazaki T et al. Antitumor activity of shikonin and its derivatives. Chem Pharm Bull (Tokyo), 1977;25(9):2392-5
4. Hashimoto S, Xu M, Masuda Y et al. Beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide. J Biochem, 1999;125(1):17-23
5. Wolf B, Schuler M, Echeverri F, Green DR. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of Caspase-activated DNase inactivation. J Bio Chem, 1999;274(43):30651-6
6. Nagata S. Apoptosis by death factor. Cell, 1997;88(3):355-65
7. Cohen GM. Caspases: the executioners of apoptosis. Biochem J, 1997;326(Pt 1):1-16
8. Charrier L, Jarry A, Toquet C et al. Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells. Cancer Reseach, 2002;62:2169-74