Activation of peripheral Th17 lymphocytes in patients with asthma

Immunological Investigations

Volumn 38, Issue 7, 2009, Pages 652-664

  Wong, C K ^a   Lun, S W M ^a   Ko, F W S ^a   Wong, P T Y ^a   Hu, S Q ^a   Chan, I H S ^a   Hui, D S C ^a   Lam, C W K ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

Author keywords

Asthma; CCR6; IL 22; Th17 cells

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CD28 ANTIBODY; CD3 ANTIBODY; CELL ANTIBODY; CHEMOKINE RECEPTOR CCR6; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 22; INTERLEUKIN 23; UNCLASSIFIED DRUG;

ADULT; ALLERGIC ASTHMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; LUNG FUNCTION TEST; LYMPHOCYTE SUBPOPULATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; ASTHMA; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RECEPTORS, CCR6; T-LYMPHOCYTES, HELPER-INDUCER; YOUNG ADULT;

EID: 70350697793     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130903062756     Document Type: Article

References (41)

1. Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., Sallusto, F. (2007). Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8:942-949.
2. Aggarwal, S., Xie, M. H., Maruoka, M., Foster, J., Gurney, A. L. (2001). Acinar cells of the pancreas are a target of interleukin-22. J. Interferon Cytokine Res. 21:1047-1053.
3. American Thoracic Society (1993). Guidelines for the evaluation of impairment/disability in patients with asthma. Am. Rev. Respir. Dis.147:1056-1061.
4. American Thoracic Society (1995). Standardization of spirometry, 1994 update. Am. J. Respir. Crit. Care Med. 152:1107-1136.
5. Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., Giudici, F., Romagnani, P., Parronchi, P., Tonelli, F., Maggi, E., Romagnani, S. (2007). Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204:1849-1861.
6. Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., Morel, F. (2005). IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J. Immunol. 174: 3695-3702.
7. Brustle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T. W., Kamradt, T., Lohoff, M. (2007). The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8:958-966.
8. Bullens, D. M., Truyen, E., Coteur, L., Dilissen. E., Hellings, P. W., Dupont, L. J., Ceuppens, J. L. (2006). IL-17 mRNA in sputum of asthmatic patients: Linking T cell driven inflammation and granulocytic influx? Respir. Res. 7:135.
9. Chabaud, M., Page, G., Miossec, P. (2001). Enhancing effect of IL-1, IL-17, and TNFalpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: Regulation by soluble receptors and Th2 cytokines. J. Immunol. 167:6015-6020.
10. Chen, Y., Thai, P., Zhao, Y. H., Ho, Y. S., DeSouza, M. M., Wu, R. (2003). Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/ autocrine loop. J. Biol. Chem. 278:17036-17043.
11. Cheung, P. F., Wong, C. K., Lam, C. W. (2008). Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: Implication for Th17 lymphocytes-mediated allergic inflammation. J. Immunol. 180:5625-5635.
12. Commins, S., Steinke, J. W., Borish, L. (2008). The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. J. Allergy Clin. Immunol. 121:1108-1111.
13. Dragon, S., Rahman, M. S., Yang, J., Unruh, H., Halayko, A. J., Gounni, A. S. (2007). IL-17 enhances IL-1beta-mediated CXCL-8 release from human airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 292:L1023-L1029.
14. Hashimoto, T., Akiyama, K., Kobayashi, N., Mori, A. (2005). Comparison of IL-17 production by helper T cells among atopic and nonatopic asthmatics and control subjects. Int. Arch. Allergy Immunol. 137 Suppl 1:51-54.
15. Hirota, K., Yoshitomi, H., Hashimoto, M., Maeda, S., Teradaira, S., Sugimoto, N., Yamaguchi, T., Nomura, T., Ito, H., Nakamura, T., Sakaguchi, N., Sakaguchi, S. (2007). Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204:2803-2812.
16. Hoshino, H., Laan, M., Sjostrand, M., Lotvall, J., Skoogh, B. E., Linden, A. (2000). Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J. Allergy Clin. Immunol. 105:143-149.
17. Kao, C.-Y., Huang, F., Chen, Y., Thai, P., Wachi, S., Kim, C., Tam, L., Wu, R. (2005). Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAKindependent but MEK/NF-{kappa} B-dependent signaling pathway. J. Immunol. 175:6676-6685.
18. Kawaguchi, M., Adachi, M., Oda, N., Kokubu, F., Huang, S. K. (2004). IL-17 cytokine family. J. Allergy Clin. Immunol. 114:1265-1273.
19. Ko, F. W. S., Lun, S. W. M., Wong, C. K., Szeto, C. C., Lam, C. W., Leung, T. F., Hui, D. S. (2007). Decreased T-bet expression and changes in chemokine levels in adults with asthma. Clin. Exp. Immunol. 147:526-532.
20. Korn, T., Bettelli, E., Oukka, M., Kuchroo, V. K. (2009). IL-17 and Th17 Cells. Annu. Rev. Immunol. 27:485-517.
21. Lam, K. K., Pang, S. C., Allan, W. G., Hill, L. E., Snell, N. J., Fayers, P. M., Nunn, A. J., Prime, F. J. (1983). Predictive nomograms for forced expiratory volume, forced vital capacity, and peak expiratory flow rate, in Chinese adults and children. Br. J. Dis. Chest 77:390-396.
22. Larche, M., Robinson, D. S., Kay, A. B. (2003). The role of T lymphocytes in the pathogenesis of asthma. J. Allergy Clin. Immunol. 111:450-463.
23. Leung, T. F., Wong, C. K., Chan, I. H. S., Ip, W. K., Lam, C. W. K., Wong, G. W. K. (2002). Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma. J. Allergy Clin. Immunol. 110:404-409.
24. Leung, T. F., Wong, C. K., Lam, C. W. Li, A. M., Ip, W. K., Wong, G. W., Fok, T. F. (2003). Plasma TARC concentration may be a useful marker for asthmatic exacerbation in children. Eur. Respir. J. 21:616-620.
25. Liang, S. C., Tan, X. Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., Fouser, L. A. (2006). Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203:2271-2279.
26. Linden, A. (2003). Rationale for targeting interleukin-17 in the lungs. Curr. Opin. Investig. Drugs 4:1304-1312.
27. Lun, S. W. M., Wong, C. K., Ko, F. W. S., Ip, W. K., Hui, D. S. C., Lam, C. W. K. (2006). Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma. J. Clin. Immunol. 26:145-152.
28. Molet, S., Hamid, Q., Davoine, F., Nutku, E., Taha, R., Pagé, N., Olivenstein, R., Elias, J., Chakir, J. (2001). IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy Clin. Immunol. 108:430-438.
29. National Heart, Lung and Blood Institute, World Heath Organisation. (2007). Global Strategy for asthma management and prevention, NIH Publication No. 02-3659, 2007 update.
30. Pène, J., Chevalier, S., Preisser, L., Vénéreau, E., Guilleux, M. H., Ghannam, S., Molès, J. P., Danger, Y., Ravon, E., Lesaux, S., Yssel, H., Gascan, H. (2008). Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol. 180: 7423-7430.
31. Sato, W., Aranami, T., Yamamura, T. (2007). Cutting edge: Human Th17 cells are identified as bearing CCR2 + CCR5- phenotype. J. Immunol. 178:7525-7529.
32. Schmidt-Weber, C. B., Akdis, M., Akdis, C. A. (2007). TH17 cells in the big picture of immunology. J. Allergy Clin. Immunol. 120:247-254.
33. Singh, S. P., Zhang, H. H., Foley, J. F., Hedrick, M. N., Farber, J. M. (2008). Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J. Immunol. 180:214-221.
34. Tesmer, L. A., Lundy, S. K., Sarkar, S., Fox, D. A. (2008). Th17 cells in human disease. Immunol. Rev. 223:87-113.
35. Viallard, J. F., Pellegrin, J. L., Ranchin, V., Schaeverbeke, T., Dehais, J., Longy-Boursier, M., Ragnaud, J. M., Leng, B., Moreau, J. F. (1999). Th1 (IL-2, interferongamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). Clin. Exp. Immunol. 115:189-195.
36. Wakashin, H., Hirose, K., Maezawa, Y. Kagami, S., Suto, A., Watanabe, N., Saito, Y., Hatano, M., Tokuhisa, T., Iwakura, Y., Puccetti, P., Iwamoto, I., Nakajima, H. (2008). IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am. J. Respir. Crit. Care Med. 178:1023-1032.
37. Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., Lecron, J. C., Kastelein, R. A., Cua, D. J., McClanahan, T. K., Bowman, E. P., de Waal Malefyt, R. (2007). Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8:950-957.
38. Wolk, K., Witte, E., Wallace, E., Döcke, W. D., Kunz, S., Asadullah, K., Volk, H. D., Sterry, W., Sabat, R. (2006). IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis. Eur. J. Immunol. 36:1309-1323.
39. Wong, C. K., Ho, C. Y., Ko, F. W. S., Chan, C. H., Ho, A. S., Hui, D. S., Lam, C. W. (2001). Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-g, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol.125:177-183.
40. Wong, C. K., Lit, L. C., Tam, L. S., Li, E. K., Wong, P. T., Lam, C. W. (2008). Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity. Clin. Immunol. 127:385-393.
41. Yssel, H., Groux, H. (2000). Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic diseases. Int. Arch. Allergy Immunol. 121:10-18.