The expression of vascular endothelial growth factor C in transplanted corneas

Current Eye Research

Volumn 34, Issue 7, 2009, Pages 553-561

  Ling, Shiqi ^a,b   Qi, Chaoxiu ^c   Li, Wei ^b   Xu, Jiangang ^b   Kuang, Wenghui ^b  

^a Guangzhou Children's Hospital   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cornea; Expression; Lymphangiogenesis; Transplantation; Vascular endothelial growth factor C

Indexed keywords

MESSENGER RNA; VASCULOTROPIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA TRANSPLANTATION; CORNEAL LYMPHANGIOGENESIS; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KERATITIS; KERATOPLASTY; LYMPH VESSEL; LYMPHANGIOGENESIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SCORING SYSTEM; SURGICAL RISK;

ANIMALS; CORNEA; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GRAFT REJECTION; IMMUNOENZYME TECHNIQUES; KERATITIS; KERATOPLASTY, PENETRATING; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MALE; RATS; RATS, INBRED F344; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 70350680754     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680902963159     Document Type: Article

References (35)

1. Cursiefen C, Cao J, Chen L, et al. Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Invest Ophthalmol Vis Sci 2004;45:2666-2673.
2. Oh SJ, Jeltsch MM, Birkenhager R, et al. VEGF and VEGFC: Specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev Biol 1997;188:96-109.
3. Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001;7:1.
4. Jeltsch M, Kaipainen A, Joukov V, et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 1997;276:1423-1425.
5. Makinen T, Jussila L, Veikkola T, et al. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med 2001;7:199-205.
6. Jiang D, Hu Y, Ling S. Expression of VEGF-C in rat cornea after alkali injury. J Huazhong Univ Sci Technolog Med Sci 2004;24:483-485.
7. Slegers TP, Torres PF, Broersma L, et al. Effect of macrophage depletion on immune effect or mechanisms during corneal allograft rejection in rats. Invest Ophthalmol Vis Sci 2000;41:2239-2247.
8. Holland EJ, Olsen TW, Sterrer J, et al. Suppression of graft rejection using 15-deoxyspergualin in the allogeneic rat penetrating keratoplasty model. Cornea 1994;13:28-32.
9. Zhang XH, Huang DP, Guo GL, et al. Coexpression of VEGFC and COX-2 and its association with lymphangiogenesis in human breast cancer. BMC Cancer 2008;8:4.
10. LariaC,Alio JL, Ruiz-Moreno JM.Combined non-steroidal therapy in experimental corneal injury. Ophthalmic Res 1997;29:145-153.
11. Zhang Z,Ma JX, Gao G, et al. Plasminogen kringle 5 inhibits alkali burn-induced corneal neovascularization. Invest Ophthalmol Vis Sci 2005;46:4062-4071.
12. Ling S, Qing X, Hu Y. Lymphangiogenesis occurring in transplanted corneas. J Huazhong Univ Sci Technolog Med Sci 2006;26:241-244.
13. Bock F, Onderka J, Dietrich T, et al. Blockade of VEGFR3- signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation. Graefes Arch Clin Exp Ophthalmol 2008;246:115-119.
14. Chen L, Hamrah P, Cursiefen C, et al. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nat Med 2004;10:813-815.
15. Ristimaki A, Narko K, Enbolm B, et al. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor C. J Biol Chem 1998; 273:8413-8418.
16. Dana MR, Qian Y, Hamrah P, et al. Twenty-five-year panorama of corneal immunology: Emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection. Cornea 2000;19:625-643.
17. Kubo H, Cao R, Brakenhielm E, et al. Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci USA 2002;99:8868-8873.
18. Stechschulte SU, Joussen AM, von Recum HA, et al. Rapid ocular angiogenic control via naked DNA delivery to cornea. Invest Ophthalmol Vis Sci 2001;42:1975-1979.
19. Keriaschki D. The crucial role of macrophages in lymphangiogenesis. J Clin Invest 2005;115:2316-2319.
20. Hamrah P, Chen L, Zhang Q, et al. Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells. Am J Pathol 2003;163:57-68.
21. Xu H, Chen M, Reid DM, et al. LYVE-1-positive macrophages are present in normal murine eyes. Invest Ophthalmol Vis Sci 2007;48:2162-2171.
22. Hamrah P, ZhangQ,DanaMR. Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) in the conjunctiva-A potential link between lymphangiogenesis and leukocyte traf- ficking on the ocular surface. Adv Exp Med Biol 2002;506:851-860.
23. Schmeisser A, Christoph M, Augstein A, et al. Apoptosis of human macrophages by Flt-4 signaling: Implications for atherosclerotic plaque pathology. Cardiovasc Res 2006;71:774-784.
24. Manryama K, Asai J, Ii M, et al. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 2007;170:1178-1191.
25. Mouta C, Heroult M. Inflammatory triggers of lymphangiogenesis. Lymphat Res Biol 2003;1:201-218; Review.
26. Ling S, Hu Y. Ipsilateral lymphadenectomy to inhibit corneal allograft rejection in rats. J Huazhong Univ Sci Technolog Med Sci 2005;25:88-90.
27. Bock F, Onderka J, Hos D, et al. Improved semiautomatic method formorphometry of angiogenesis and lymphangiogenesis in corneal flat mounts. Exp Eye Res Aug 26, 2008 [Epub ahead of print].
28. Bock F, Onderka J, Dietrich T, et al. Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest Ophthalmol Vis Sci 2007;48:2545-2552.
29. Cursiefen C, Chen L, Borges LP, et al. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest 2004;113:1040-1050.
30. Cursiefen C, Maruyama K, Jackson DG, et al. Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation. Cornea 2006;25:443-447.
31. CursiefenC, Schlötzer-SchrehardtU,KüchleM, et al. Lymphatic vessels in vascularized human corneas: Immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci 2002;43(7):2127-2135.
32. Cursiefen C, Chen L, Saint-Geniez M, et al. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci USA 2006;103(30):11405-11410.
33. Kaipainen A, Korhonen J, Mustonen T, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 1995;92:3566-3570.
34. Cao Y, Linden P, Farnebo J, et al. Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci USA 1998;95:14389-14394.
35. Rissanen TT, Markkanen JE, Gruchala M, et al. VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ Res 2003;92:1098-1106. 561